My research focuses on non-invasive diagnostics, which are tailored to our youngest patients. We aim to discover biological insights by novel imaging approaches and the rapid translation to clinical applications.
Research projects
Imaging of tissue degeneration and fibrosis
Imaging of inflammatory processes and therapeutic monitoring
Intraoperative imaging of neonates
AI-supported imaging classification of muscular Diseases –
Imaging of rare Diseases
Point of care low magnetic field MRI imaging in pediatrics
Current projects
FET-O-MO-DE - Fetal Optoacoustic Monitoring Device
(Third Party Funds Single)
Term: 1. January 2024 - 30. June 2026Funding source: Bayerisches Staatsministerium für Wirtschaft, Landesentwicklung und Energie (StMWi) (seit 2018)
FunctIonal optoacousticS for imaging Early onsEt of Gut inflammation
(Third Party Funds Single)
Term: 1. December 2023 - 30. November 2028Funding source: European Research Council (ERC)
SMART-3D
(Third Party Funds Single)
Term: 1. May 2022 - 30. April 2025Funding source: Bayerische Forschungsstiftung
Shortening the path to rare disease diagnosis by using newborn genetic screening and digital technologies
(Third Party Funds Group – Sub project)
Overall project: Shortening the path to rare disease diagnosis by using newborn genetic screening and digital technologiesTerm: 1. October 2021 - 30. September 2026Funding source: Sonstige EU-Programme (z. B. RFCS, DG Health, IMI, Artemis)
Recent publications
2024
Almási-Sperling, V., Gall, C., Haney, B., Latzel, N., Knieling, F., Hilger, A.,... Rother, U. (2024). Long-Term Experience of Arterio-Venous Fistula Surgery in Children on Hemodialysis . Journal of Clinical Medicine , 13 (12). https://doi.org/10.3390/jcm13123577
Fagni, F., Tascilar, K., Noversa de Sousa, R., Bayat, S., Sollfrank, L., Kleyer, A.,... Simon, D. (2024). Unveiling Metabolic Similarities of Entheses in Patients with Psoriasis and Psoriatic Arthritis Using Noninvasive In Vivo Molecular Imaging: Results From a Cross-sectional Exploratory Study . Arthritis and Rheumatology , 76 (9), 1387-1396. https://doi.org/10.1002/art.42917
Hörning, A., Jüngert, J., Siebenlist, G., Knieling, F., & Regensburger, A. (2024). Ultrasound in Pediatric Inflammatory Bowel Disease—A Review of the State of the Art and Future Perspectives . Children , 11 (2). https://doi.org/10.3390/children11020156
Li, Y., Gröhl, J., Haney, B., Caranovic, M., Lorenz-Meyer, E., Papatheodorou, N.,... Rother, U. (2024). Teachability of multispectral optoacoustic tomography . Journal of Biophotonics . https://doi.org/10.1002/jbio.202400106
Martin, S., Angolini, E., Audi, J., Bertini, E., Bruno, L.P., Coulter, J.,... Veldwijk, J. (2024). Patient preferences in genetic newborn screening for rare diseases: study protocol . BMJ Open , 14 (4). https://doi.org/10.1136/bmjopen-2023-081835
Nedoschill, E., Wagner, A.L., Danko, V., Bühler, A., Raming, R., Jüngert, J.M.,... Regensburger, A. (2024). Monitoring spinal muscular atrophy with three-dimensional optoacoustic imaging . Med , 5 (5), 469-478.e3. https://doi.org/10.1016/j.medj.2024.02.010
Noversa de Sousa, R., Tascilar, K., Corte, G., Atzinger, A., Minopoulou, I., Ohrndorf, S.,... Corte, G. (2024). Metabolic and molecular imaging in inflammatory arthritis . RMD Open , 10 (1). https://doi.org/10.1136/rmdopen-2023-003880
Regensburger, A., Eckstein, M., Wetzl, M., Raming, R., Paulus, L.-P., Bühler, A.,... Knieling, F. (2024). Multispectral optoacoustic tomography enables assessment of disease activity in paediatric inflammatory bowel disease . Photoacoustics , 35 . https://doi.org/10.1016/j.pacs.2023.100578
Schöffl, I., Raming, R., Tratzky, J.P., Regensburger, A., Kraus, C., Wällisch, W.,... Weigelt, A. (2024). Cardiopulmonary function in paediatric post-COVID-19: a controlled clinical trial . European Journal of Pediatrics . https://doi.org/10.1007/s00431-024-05421-w
Tan, L., Zschüntzsch, J., Meyer, S., Stobbe, A., Bruex, H., Regensburger, A.,... Knieling, F. (2024). Non-invasive optoacoustic imaging of glycogen-storage and muscle degeneration in late-onset Pompe disease. Nature Communications , 15 (1). https://doi.org/10.1038/s41467-024-52143-6
Träger, A.P., Günther, J., Raming, R., Paulus, L.-P., Lang, W., Meyer, A.,... Rother, U. (2024). Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease . Photoacoustics , 35 . https://doi.org/10.1016/j.pacs.2023.100579
Vonk, J., Knieling, F., & Kruijff, S. (2024). Collection on clinical photoacoustic imaging . European Journal of Nuclear Medicine and Molecular Imaging . https://doi.org/10.1007/s00259-024-06780-0
Zetzmann, K., Papatheodorou, N., Rühl, E., Yagshyyev, S., Haney, B., Moosmann, O.,... Rother, U. (2024). Detection of wound healing disorders after major amputations by measurements of the microcirculation: A prospective single-center study . SAGE Open Medicine , 12 . https://doi.org/10.1177/20503121241263244
2023
Assi, H., Cao, R., Castelino, M., Cox, B., Gilbert, F.J., Gröhl, J.,... Bohndiek, S.E. (2023). A review of a strategic roadmapping exercise to advance clinical translation of photoacoustic imaging: From current barriers to future adoption . Photoacoustics , 32 . https://doi.org/10.1016/j.pacs.2023.100539
Bühler, A., Brown, E., Paulus, L.-P., Eckstein, M., Thoma, O.-M., Oraiopoulou, M.-E.,... Regensburger, A. (2023). Transrectal Absorber Guide Raster-Scanning Optoacoustic Mesoscopy for Label-Free In Vivo Assessment of Colitis . Advanced Science . https://doi.org/10.1002/advs.202300564
Danko, V., Jüngert, J.M., Schüssler, S., Bühler, A., Klett, D., Federle, A.,... Wagner, A. (2023). Hybrid reflected-ultrasound computed tomography versus B-mode-ultrasound for muscle scoring in spinal muscular atrophy . Journal of Neuroimaging . https://doi.org/10.1111/jon.13081
Günther, J., Knieling, F., Träger, A.P., Lang, W., Meyer, A., Regensburger, A.,... Rother, U. (2023). Targeting Muscular Hemoglobin Content for Classification of Peripheral Arterial Disease by Noninvasive Multispectral Optoacoustic Tomography . Journal of the American College of Cardiology : Cardiovascular imaging , 16 (5), 719-721. https://doi.org/10.1016/j.jcmg.2022.11.010
Paulus, L.-P., Bühler, A., Wagner, A., Raming, R., Jüngert, J., Simon, D.,... Knieling, F. (2023). Contrast-Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract . Advanced Science . https://doi.org/10.1002/advs.202302562
Paulus, L.-P., Wagner, A., Buehler, A., Raming, R., Jüngert, J., Simon, D.,... Regensburger, A. (2023). Multispectral optoacoustic tomography of the human intestine – temporal precision and the influence of postprandial gastrointestinal blood flow . Photoacoustics , 30 . https://doi.org/10.1016/j.pacs.2023.100457
Schnell, A., Jüngert, J.M., Klett, D., Hober, H., Kaiser, N., Ruppel, R.,... Regensburger, A. (2023). Increase of liver stiffness and altered bile acid metabolism after triple CFTR modulator initiation in children and young adults with cystic fibrosis . Liver International . https://doi.org/10.1111/liv.15544
Späth, M., Rohde, M., Ni, D., Knieling, F., Stelzle, F., Schmidt, M.,... Hohmann, M. (2023). Author Correction: The influence of the optical properties on the determination of capillary diameters (Scientific Reports, (2022), 12, 1, (270), 10.1038/s41598-021-04359-5) . Scientific Reports , 13 (1). https://doi.org/10.1038/s41598-022-26996-0
Wachter, F., Knieling, F., Raming, R., Simon, D., Wölfle, J., Hörning, A.,... Regensburger, A. (2023). Routine Surveillance of SARS-CoV-2 Serostatus in Pediatrics Allows Monitoring of Humoral Response . Microorganisms , 11 (12), 2919. https://doi.org/10.3390/microorganisms11122919
2022
Goebel, C.A., Brown, E., Fahlbusch, F., Wagner, A., Buehler, A., Raupach, T.,... Knieling, F. (2022). High-resolution label-free mapping of murine kidney vasculature by raster-scanning optoacoustic mesoscopy: an ex vivo study . Molecular and Cellular Pediatrics , 9 (1). https://doi.org/10.1186/s40348-022-00144-0
Heiß, R., Tan, L., Schmidt, S., Regensburger, A., Ewert, F., Mammadova, D.,... Knieling, F. (2022). Pulmonary Dysfunction after Pediatric COVID-19 . Radiology . https://doi.org/10.1148/radiol.221250
Knieling, F., Cesnjevar, R., Regensburger, A., Wagner, A., Purbojo, A., Dittrich, S.,... Rüffer, A. (2022). Transfontanellar Contrast-enhanced US for Intraoperative Imaging of Cerebral Perfusion during Neonatal Arterial Switch Operation . Radiology , 304 (1), 164-173. https://doi.org/10.1148/radiol.212044
Regensburger, A., Wagner, A., Danko, V., Jüngert, J.M., Federle, A., Klett, D.,... Knieling, F. (2022). Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients . Photoacoustics , 25 . https://doi.org/10.1016/j.pacs.2021.100315
Schlereth, M., Stromer, D., Breininger, K., Wagner, A., Tan, L., Maier, A., & Knieling, F. (2022). Automatic Classification of Neuromuscular Diseases in Children Using Photoacoustic Imaging . In Klaus Maier-Hein, Thomas M. Deserno, Heinz Handels, Andreas Maier, Christoph Palm, Thomas Tolxdorff (Eds.), Informatik aktuell (pp. 285-290). Heidelberg, DEU: Springer Science and Business Media Deutschland GmbH.
Späth, M., Rohde, M., Ni, D., Knieling, F., Stelzle, F., Schmidt, M.,... Hohmann, M. (2022). The influence of the optical properties on the determination of capillary diameters . Scientific Reports , 12 . https://doi.org/10.1038/s41598-021-04359-5
Stirm, M., Fonteyne, L.M., Shashikadze, B., Stöckl, J.B., Kurome, M., Keßler, B.,... Wolf, E. (2022). Pig models for Duchenne muscular dystrophy – from disease mechanisms to validation of new diagnostic and therapeutic concepts . Neuromuscular Disorders . https://doi.org/10.1016/j.nmd.2022.04.005
Tascilar, K., Fagni, F., Kleyer, A., Bayat, S., Heidemann, R., Steiger, F.,... Simon, D. (2022). NON-INVASIVE IN VIVO METABOLIC PROFILING OF INFLAMMATION IN JOINTS AND ENTHESES BY OPTOACOUSTIC IMAGING . In ANNALS OF THE RHEUMATIC DISEASES (pp. 1032-1032). LONDON: BMJ PUBLISHING GROUP.
Tascilar, K., Fagni, F., Kleyer, A., Bayat, S., Heidemann, R., Steiger, F.,... Simon, D. (2022). Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography . Rheumatology . https://doi.org/10.1093/rheumatology/keac346
Wachter, F., Regensburger, A., Peter, A.S., Knieling, F., Wagner, A., Simon, D.,... Rauh, M. (2022). Continuous monitoring of SARS-CoV-2 seroprevalence in children using residual blood samples from routine clinical chemistry . Clinical Chemistry and Laboratory Medicine . https://doi.org/10.1515/cclm-2022-0037
2021
Aguilar, C., Regensburger, A., Knieling, F., Wagner, A., Siebenlist, G., Wölfle, J.,... Jüngert, J.M. (2021). Pediatric Buried Bumper Syndrome: Diagnostic Validity of Transabdominal Ultrasound and Artificial Intelligence . Ultraschall in der Medizin . https://doi.org/10.1055/a-1471-3039
Regensburger, A., Brown, E., Krönke, G., Waldner, M., & Knieling, F. (2021). Optoacoustic Imaging in Inflammation . Biomedicines , 9 (5). https://doi.org/10.3390/biomedicines9050483
Rüffer, A., Knieling, F., Cesnjevar, R., Regensburger, A., Purbojo, A., Dittrich, S.,... Jüngert, J.M. (2021). Equal cerebral perfusion during extended aortic coarctation repair . European Journal of Cardio-Thoracic Surgery , 61 (2), 299-306. https://doi.org/10.1093/ejcts/ezab415
Wagner, A., Danko, V., Federle, A., Klett, D., Simon, D., Heiß, R.,... Knieling, F. (2021). Precision of handheld multispectral optoacoustic tomography for muscle imaging . Photoacoustics , 21 . https://doi.org/10.1016/j.pacs.2020.100220
Wildner, D., Heinzerling, L., Scheulen, M.E., Kämpgen, E., Schuler, G., Strobel, D.,... Knieling, F. (2021). Assessment of sorafenib induced changes in tumor perfusion of uveal melanoma metastases with dynamic contrast-enhanced ultrasound (DCE-US) . Journal of Cancer Research and Clinical Oncology . https://doi.org/10.1007/s00432-021-03666-8
2020
Knieling, F., Rüffer, A., Cesnjevar, R., Regensburger, A., Purbojo, A., Dittrich, S.,... Jüngert, J.M. (2020). Transfontanellar Contrast-Enhanced Ultrasound for Monitoring Brain Perfusion During Neonatal Heart Surgery . Circulation: Cardiovascular Imaging , 13 (3), e010073-. https://doi.org/10.1161/CIRCIMAGING.119.010073
Regensburger, A., Wagner, A., Claussen, J., Waldner, M., & Knieling, F. (2020). Shedding light on pediatric diseases: multispectral optoacoustic tomography at the doorway to clinical applications. Molecular and Cellular Pediatrics , 7 (1). https://doi.org/10.1186/s40348-020-00095-4
Regensburger, A., Wagner, A., Hanslik, G., Schuessler, S.C., Fahlbusch, F., Wölfle, J.,... Knieling, F. (2020). Ultra-high-frequency ultrasound in patients with spinal muscular atrophy: A retrospective feasibility study . Muscle & Nerve . https://doi.org/10.1002/mus.26796
Related Research Fields
Contact:
My research focuses on non-invasive diagnostics, which are tailored to our youngest patients. We aim to discover biological insights by novel imaging approaches and the rapid translation to clinical applications.
Research projects
FET-O-MO-DE - Fetal Optoacoustic Monitoring Device
(Third Party Funds Single)
Funding source: Bayerisches Staatsministerium für Wirtschaft, Landesentwicklung und Energie (StMWi) (seit 2018)
FunctIonal optoacousticS for imaging Early onsEt of Gut inflammation
(Third Party Funds Single)
Funding source: European Research Council (ERC)
SMART-3D
(Third Party Funds Single)
Funding source: Bayerische Forschungsstiftung
Shortening the path to rare disease diagnosis by using newborn genetic screening and digital technologies
(Third Party Funds Group – Sub project)
Term: 1. October 2021 - 30. September 2026
Funding source: Sonstige EU-Programme (z. B. RFCS, DG Health, IMI, Artemis)
2024
2023
2022
2021
2020
Related Research Fields
Contact: