We are interested in the functioning of molecular machines such as voltage-gated ion channels or Alzheimer’s Disease protease BACE1. Using patch-clamp recordings or time-resolved optical techniques, the behavior of single proteins is investigated. Subsequent Markov modelling of acquired time series using simulations or Deep Neural Networks provides insight into the molecular composition and function.
Research projects
Time Series Analysis
Modelling
HPC Simulations
Deep Neural Networks
Voltage-Gated Ion Channels
Alzheimer’s Disease Protease BACE1
Recent publications
2023
Oikonomou, E., Gruber, T., Achanta, R.C., Höller, S., Alzheimer, C., Wellein, G., & Huth, T. (2023). 2D-dwell-time analysis with simulations of ion-channel gating using high-performance computing. Biophysical Journal . https://doi.org/10.1016/j.bpj.2023.02.023
2021
Anni, D., Weiss, E.-M., Guhathakurta, D., Akdas, E.Y., Klueva, J., Zeitler, S.,... Fejtová, A. (2021). Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation . Cellular and Molecular Life Sciences . https://doi.org/10.1007/s00018-021-03835-5
2020
Thull, S., Neacsu, C., O'Reilly, A.O., Bothe, S., Hausmann, R., Huth, T.,... Lampert, A. (2020). Dataset of electrophysiological patch-clamp recordings of the effect of the compounds deltamethrin, ATx-II and β4-peptide on human cardiac Nav1.5 sodium channel gating properties . Data in Brief , 31 . https://doi.org/10.1016/j.dib.2020.105844
Thull, S., Neacsu, C., O'Reilly, A.O., Bothe, S., Hausmann, R., Huth, T.,... Lampert, A. (2020). Mechanism underlying hooked resurgent-like tail currents induced by an insecticide in human cardiac Nav1.5 . Toxicology and Applied Pharmacology , 397 . https://doi.org/10.1016/j.taap.2020.115010
Related Research Fields
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We are interested in the functioning of molecular machines such as voltage-gated ion channels or Alzheimer’s Disease protease BACE1. Using patch-clamp recordings or time-resolved optical techniques, the behavior of single proteins is investigated. Subsequent Markov modelling of acquired time series using simulations or Deep Neural Networks provides insight into the molecular composition and function.
Research projects
No projects found.
2023
2021
2020
Related Research Fields
Contact: