Prof. Arndt Hartmann

Pathological Institute

Research projects

Pathology and Molecular Pathology with research focus on bladder cancer, renal cell carcinoma, head and neck and breast cancer.
Prognostic and predictive molecular tumour markers.
Digital pathology and devolopment of AI prediction models for diagnosis, molecular changes and therapy prediction.
Characterization of the immunological tumor microenvironment and correlation to response to immunooncological therapy.

D039: EMT specific splicing mediates ferroptosis sensitivity

(FAU Funds)

Term: 1. July 2023 - 31. December 2025

Abstract

We have demonstrated that the EMT-activator ZEB1 provides cancer cells not only with aberrant motility, but also with survival traits enabling tumor progression, metastasis and drug resistance. Our aim is to eliminate these aggressive untargetable EMT-state cancer cells, which strikingly show a high sensitivity to ferroptotic cell death. In this project, we want to elucidate the molecular basis of ZEB1 associated ferroptosis sensitivity to exploit it as a novel therapeutic target.

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J101: AI-based support for histopathology evaluation of autoinflammatory and malignant GI diseases

(FAU Funds)

Term: 1. January 2023 - 31. December 2025

Abstract

The proposed projects aims at using methods from AI-based image analysis to evaluate histopathologic samples from the field of gastrointestinal pathology. Specifically, samples from patients with inflammatory bowel diseases and malignancies of the colorectum will be evaluated. It is the aim of the project to develop algorithms that quantify and detect specific morphologic properties of these samples and integrate them with other data modalities.

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2025

Öttl, M., Mei, S., Wilm, F., Steenpaß, J., Rübner, M., Hartmann, A.,... Breininger, K. (2025). Analysing Diffusion Segmentation for Medical Images. (Unpublished, Submitted).

2024

Angeloni, M., van Doeveren, T., Lindner, S., Volland, P., Schmelmer, J., Foersch, S.,... Bahlinger, V. (2024). A deep-learning workflow to predict upper tract urothelial carcinoma protein-based subtypes from H&E slides supporting the prioritization of patients for molecular testing. Journal of Pathology: Clinical Research, 10(2). https://doi.org/10.1002/2056-4538.12369
Bahlinger, V., Branz, A., Strissel, P., Strick, R., Lange, F., Geppert, C.-I.,... Eckstein, M. (2024). Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts. Histopathology. https://doi.org/10.1111/his.15130
Bahlinger, V., Stöhr, R., Hartmann, A., Hes, O., & Agaimy, A. (2024). Small cell neuroendocrine carcinoma and poorly differentiated rhabdomyosarcomas of the urinary bladder in adults—A comparative analysis in favor of a common histogenesis. Virchows Archiv. https://doi.org/10.1007/s00428-024-03835-3
Bertz, S., Bahlinger, V., Lange, F., Hartmann, A., & Eckstein, M. (2024). Muscle-invasive and metastatic urothelial carcinoma of the urinary bladder: Current state of histopathologic, molecular, and immunologic prognostic and predictive factors Das muskelinvasive und metastasierte Urothelkarzinom der Harnblase: Aktueller Stand histopathologischer, molekularer und immunologischer Prognose- und Prädiktionsfaktoren. Die Pathologie. https://doi.org/10.1007/s00292-024-01347-0
Dietl, A., Beckmann, M., Stübs, F., Gaß, P., Emons, J., Hartmann, A., & Erber, R. (2024). PD-L1 Expression and Silva Invasion Pattern in Villoglandular Adenocarcinoma of the Uterine Cervix. International Journal of Gynecological Pathology, 43(4), 397-404. https://doi.org/10.1097/PGP.0000000000001006
Downes, M.R., Hartmann, A., Shen, S., Tsuzuki, T., van Rhijn, B.W.G., Bubendorf, L.,... Cheng, L. (2024). International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 1: Comparison of Bladder Cancer Grading System Performance. American Journal of Surgical Pathology, 48(1), e1-e10. https://doi.org/10.1097/PAS.0000000000002059
Eckstein, M., Matek, C., Wagner, P., Erber, R., Büttner-Herold, M., Wild, P.J.,... Bertz, S. (2024). Proposal for a Novel Histological Scoring System as a Potential Grading Approach for Muscle-invasive Urothelial Bladder Cancer Correlating with Disease Aggressiveness and Patient Outcomes. European Urology Oncology, 7(1), 128-138. https://doi.org/10.1016/j.euo.2023.07.011
Elsner, F., Khamitov, K., Hinsen, M., Sirbu, H., & Hartmann, A. (2024). Hattori-Zyste – eine seltene Läsion im posterioren Mediastinum. Die Pathologie. https://doi.org/10.1007/s00292-024-01334-5
Fasching, P., Hu, C., Hart, S.N., Rübner, M., Polley, E.C., Gnanaolivu, R.D.,... Couch, F.J. (2024). Susceptibility gene mutations in germline and tumors of patients with HER2-negative advanced breast cancer. npj Breast Cancer, 10(1). https://doi.org/10.1038/s41523-024-00667-x
Gehring, A., Hübner, K., Rani, H., Erlenbach-Wünsch, K., Merkel, S., Mahadevan, V.,... Schneider-Stock, R. (2024). DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells. Scientific Reports, 14. https://doi.org/10.1038/s41598-024-52437-1
Griffin, J., Hartmann, A., & Comperat, E. (2024). Variation in cystectomy pathology reporting practice—results from an international survey of 212 pathologists. Virchows Archiv. https://doi.org/10.1007/s00428-024-03924-3
Haas, M., Engelmann, S.U., Mayr, R., Gossler, C., Pickl, C., Kälble, S.,... Eckstein, M. (2024). A novel grading approach predicts worse outcomes in stage pT1 non-muscle-invasive bladder cancer. Bju International. https://doi.org/10.1111/bju.16298
Haas, M., Kriegmair, M.C., Breyer, J., Sikic, D., Wezel, F., Roghmann, F.,... Eckstein, M. (2024). Improving detection of carcinoma in situ in bladder cancer: urinary cytology vs the Xpert® BC Monitor. Bju International. https://doi.org/10.1111/bju.16389
Hecht, M., Frey, B., Gaipl, U., Tianyu, X., Eckstein, M., Donaubauer, A.-J.,... Kist, A. (2024). Machine Learning-assisted immunophenotyping of peripheral blood identifies innate immune cells as best predictor of response to induction chemo-immunotherapy in head and neck squamous cell carcinoma – knowledge obtained from the CheckRad-CD8 trial. Neoplasia, 49. https://doi.org/10.1016/j.neo.2023.100953
Heger, L., Heidkamp, G.F., Amon, L., Nimmerjahn, F., Bäuerle, T., Maier, A.,... Dudziak, D. (2024). Unbiased high-dimensional flow cytometry identified NK and DC immune cell signature in Luminal A-type and triple negative breast cancer. OncoImmunology, 13(1). https://doi.org/10.1080/2162402X.2023.2296713
Kerr, K.M., Bubendorf, L., Lopez-Rios, F., Khalil, F., Roy-Chowdhuri, S., Joubert, P.,... Dacic, S. (2024). Optimizing tissue stewardship in non-small cell lung cancer to support molecular characterization and treatment selection: statement from a working group of thoracic pathologists. Histopathology, 84(3), 429-439. https://doi.org/10.1111/his.15078
Klümper, N., Brägelmann, J., Bahlinger, V., Hartmann, A., Grünwald, V., Kuppe, C.,... Eckstein, M. (2024). Membranous expression of target protein is required for ADC response in urothelial cancer. European Urology. https://doi.org/10.1016/j.eururo.2024.06.023
Krebs, M., Haller, F., Spörl, S., Gerhard-Hartmann, E., Utpatel, K., Maurus, K.,... Lüke, F. (2024). The WERA cancer center matrix: Strategic management of patient access to precision oncology in a large and mostly rural area of Germany. European Journal of Cancer, 207. https://doi.org/10.1016/j.ejca.2024.114144
Kuritcyn, P., Kletzander, R., Eisenberg, S., Wittenberg, T., Bruns, V., Evert, K.,... Benz, M. (2024). Towards interactive AI-authoring with prototypical few-shot classifiers in histopathology. Journal of Pathology Informatics, 15. https://doi.org/10.1016/j.jpi.2024.100388
Lange, F., Geppert, C.-I., Bahlinger, V., Bertz, S., Stöhr, R., Sikic, D.,... Eckstein, M. (2024). Digital volumetric assessment of CIS and tumor mass compliments conventional histopathological assessment in muscle-invasive urothelial bladder cancer. Virchows Archiv. https://doi.org/10.1007/s00428-024-03875-9
Liu, J., Wang, X., Jiang, W., Azoitei, A., Eiseler, T., Eckstein, M.,... Günes, C. (2024). Impairment of α-tubulin and F-actin interactions of GJB3 induces aneuploidy in urothelial cells and promotes bladder cancer cell invasion. Cellular & Molecular Biology Letters, 29(1). https://doi.org/10.1186/s11658-024-00609-2
Melchior, L., Hirschmann, A., Hofman, P., Bontoux, C., Concha, A., Mrabet-Dahbi, S.,... Hartmann, A. (2024). Multicenter evaluation of an automated, multiplex, RNA-based molecular assay for detection of ALK, ROS1, RET fusions and MET exon 14 skipping in NSCLC. Virchows Archiv, 484(4), 677-686. https://doi.org/10.1007/s00428-024-03778-9
Melchior, L., Hirschmann, A., Hofman, P., Bontoux, C., Concha, A., Mrabet‑Dahbi, S.,... Hartmann, A. (2024). Correction to: Multicenter evaluation of an automated, multiplex, RNA-based molecular assay for detection of ALK, ROS1, RET fusions and MET exon 14 skipping in NSCLC (Virchows Archiv, (2024), 10.1007/s00428-024-03778-9). Virchows Archiv. https://doi.org/10.1007/s00428-024-03800-0
Mikuteit, M., Zschäbitz, S., Autenrieth, M., Weichert, W., Hartmann, A., Steffens, S., & Erlmeier, F. (2024). Expression of Nectin-4 in Chromophobe Renal Cell Carcinoma in a Multicenter Cohort: Early Prognostic and Therapeutic Considerations. Oncology, 503-509. https://doi.org/10.1159/000535473
Pastorino, G., Sheraj, I., Hübner, K., Ferrero, G., Kunze, P., Hartmann, A.,... Schneider-Stock, R. (2024). A partial epithelial-mesenchymal transition signature for highly aggressive colorectal cancer cells that survive under nutrient restriction. Journal of Pathology. https://doi.org/10.1002/path.6240
Pöschke, P., Gaß, P., Krückel, A., Keller, K., Erber, R., Hartmann, A.,... Emons, J. (2024). Clinical and Surgical Evaluation of Sentinel Node Biopsy in Patients with Early-Stage Endometrial Cancer and Atypical Hyperplasia Klinische und chirurgische Evaluation der Sentinel-Lymphknoten- Biopsie in Patientinnen mit Endometriumkarzinom im Fr hstadium und atypischer Hyperplasie. Geburtshilfe und Frauenheilkunde, 84(5), 470-476. https://doi.org/10.1055/a-2293-5700
Raptis, D., Maak, M., Krautz, C., Merkel, S., Brunner, M., Agaimy, A.,... Schildberg, C.W. (2024). Surgical and oncological outcome after extended lymph node dissection for carcinoma of the stomach and the esophagogastric junction: a retrospective analysis from an experienced single center. Archives of Medical Science, 20(1), 124-132. https://doi.org/10.5114/aoms/141165
Regensburger, A., Eckstein, M., Wetzl, M., Raming, R., Paulus, L.-P., Bühler, A.,... Knieling, F. (2024). Multispectral optoacoustic tomography enables assessment of disease activity in paediatric inflammatory bowel disease. Photoacoustics, 35. https://doi.org/10.1016/j.pacs.2023.100578
Reike, M.J., Reicherz, A., Tully, K.H., Bahlburg, H., Maas, M., Bach, P.,... Roghmann, F. (2024). An Empirical Survey on the Adaption of Neoadjuvant Chemotherapy in Bladder Cancer. Urologia Internationalis, 183-189. https://doi.org/10.1159/000536321
Rüschoff, J., Kumar, G., Badve, S., Jasani, B., Krause, E., Rioux-Leclercq, N.,... Hartmann, A. (2024). Scoring PD-L1 Expression in Urothelial Carcinoma: An International Multi-Institutional Study on Comparison of Manual and Artificial Intelligence Measurement Model (AIM-PD-L1) Pathology Assessments. Virchows Archiv. https://doi.org/10.1007/s00428-024-03795-8
Saal, J., Grünwald, V., Bald, T., Ritter, M., Brossart, P., Tomita, Y.,... Klümper, N. (2024). On-treatment Modified Glasgow Prognostic Score Provides Predictive Information Complementary to Radiological Staging in Metastatic Urothelial Carcinoma on Immunotherapy. European Urology Oncology, 7(3), 328-331. https://doi.org/10.1016/j.euo.2023.11.005
Saner, F.A., Takahashi, K., Budden, T., Pandey, A., Ariyaratne, D., Zwimpfer, T.A.,... Garsed, D.W. (2024). Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma. Clinical Cancer Research, 30(16), 3481-3498. https://doi.org/10.1158/1078-0432.CCR-23-3552
Schlieben, L.D., Carta, M.G., Moskalev, E., Stöhr, R., Metzler, M., Besendörfer, M.,... Ferrazzi, F. (2024). Machine Learning-Supported Diagnosis of Small Blue Round Cell Sarcomas Using Targeted RNA Sequencing. Journal of Molecular Diagnostics, 26(5), 387-398. https://doi.org/10.1016/j.jmoldx.2024.02.002
Schmidt, C., Stöhr, R., Dimitrova, L., Beckmann, M., Rübner, M., Fasching, P.,... Erber, R. (2024). Quality-Assured Analysis of PIK3CA Mutations in Hormone Receptor–Positive/Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer Tissue: A Story About the Need for Proficiency Testing for High-Quality Molecular Biomarker Reporting in Precision Medicine. Journal of Molecular Diagnostics. https://doi.org/10.1016/j.jmoldx.2024.04.003
Smolka, C., Eckstein, M., Jung, R., Lieb, V., Sikic, D., Stöhr, R.,... Wach, S. (2024). Prognostic and Predictive Potential of CCL5 Expression in Muscle-Invasive Bladder Cancer Patients. International Journal of Molecular Sciences, 25(12). https://doi.org/10.3390/ijms25126325
Stübs, F., Behrens, A., Seibold, A., Adler, W., Geppert, C.-I., Hartmann, A.,... Dietl, A. (2024). Impact of the Corona Pandemic on Cervical Cancer Screening Assessment. In Vivo, 38(2), 734-740. https://doi.org/10.21873/invivo.13495
Vitali, F., Merkel, S., Schubart, C., Schmid, A., Eckstein, M., Stöhr, R.,... Wein, A. (2024). Biomarker-stratified first-line treatment of right-sided metastatic colon cancer with interdisciplinary collaboration in the IVOPAK II trial. Anti-Cancer Drugs. https://doi.org/10.1097/CAD.0000000000001636
Vitali, F., Rath, T., Klenske, E., Vögele, A.-L., Ganzleben, I., Zundler, S.,... Atreya, R. (2024). Long-term outcomes of cyclosporin induction and ustekinumab maintenance combination therapy in patients with steroid-refractory acute severe ulcerative colitis. Therapeutic Advances in Gastroenterology, 17. https://doi.org/10.1177/17562848231218555
Wagner, P., Gaß, P., Pöschke, P., Eckstein, M., Gloßner, L., Hartmann, A.,... Erber, R. (2024). Spatial expression of claudin 18.2 in matched primaries and metastases of tubo-ovarian carcinoma of all subtypes. Virchows Archiv. https://doi.org/10.1007/s00428-024-03756-1
Wunderle, M., Heindl, F., Behrens, A., Häberle, L., Hack, C., Heusinger, K.,... Emons, J. (2024). Correlation of RANK and RANKL with mammographic density in primary breast cancer patients. Archives of Gynecology and Obstetrics. https://doi.org/10.1007/s00404-024-07495-1
van Gennep, E.J., Claps, F., Bostrom, P.J., Shariat, S.F., Neuzillet, Y., Zlotta, A.R.,... van Rhijn, B.W.G. (2024). Multi-Center Assessment of Lymph-Node Density and Nodal-Stage to Predict Disease-Specific Survival in Patients with Bladder Cancer Treated by Radical Cystectomy. Bladder Cancer, 10(2), 119-132. https://doi.org/10.3233/BLC-230086

2023

Abele, N., Tiemann, K., Krech, T., Wellmann, A., Schaaf, C., Länger, F.,... Lang, T. (2023). Noninferiority of Artificial Intelligence-Assisted Analysis of Ki-67 and Estrogen/Progesterone Receptor in Breast Cancer Routine Diagnostics. Modern Pathology, 36(3), 100033-. https://doi.org/10.1016/j.modpat.2022.100033
Bahlinger, V., Eckstein, M., Hartmann, A., & Stöhr, R. (2023). Evaluation of FGFR Alteration Status in Urothelial Tumors. In Michèle J. Hoffmann, Nadine T. Gaisa, Roman Nawroth, Thorsten H. Ecke (Eds.), Urothelial Carcinoma - Methods and Protocols. (pp. 283-291). Humana Press Inc..
Bahlinger, V., Hartmann, A., & Eckstein, M. (2023). Assessment of PD-L1 Status in Urothelial Cancer. In Michèle J. Hoffmann, Nadine T. Gaisa, Roman Nawroth, Thorsten H. Ecke (Eds.), Urothelial Carcinoma - Methods and Protocols. (pp. 249-255). Humana Press Inc..
Bahlinger, V., Hartmann, A., & Eckstein, M. (2023). Immunotherapy in Genitourinary Cancers: Role of Surgical Pathologist for Detection of Immunooncologic Predictive Factors. Advances in Anatomic Pathology, 30(3), 203-210. https://doi.org/10.1097/PAP.0000000000000383
Behrens, A., Wurmthaler, L., Heindl, F., Gaß, P., Häberle, L., Volz, B.,... Hübner, H. (2023). RANK and RANKL Expression in Tumors of Patients with Early Breast Cancer. Geburtshilfe und Frauenheilkunde. https://doi.org/10.1055/a-2192-2998
Beijert, I.J., Cheng, L., Liedberg, F., Plass, K., Williamson, S.R., Gontero, P.,... Downes, M.R. (2023). International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members. European Urology Open Science, 52, 154-165. https://doi.org/10.1016/j.euros.2023.03.019
Berner, M., Hartmann, A., & Erber, R. (2023). Role of Surgical Pathologist for Detection of Predictive Immuno-oncological Factors in Breast Cancer. Advances in Anatomic Pathology, 30(3), 195-202. https://doi.org/10.1097/PAP.0000000000000382
Bolenz, C., Kunath, F., Zengerling, F., Wezel, F., Schmidt, S., Hartmann, A., & Eckstein, M. (2023). Increasing Biomarker Guidance in the Treatment of Urothelial Carcinoma: Systematic Review of International Clinical Trials. Urologia Internationalis. https://doi.org/10.1159/000527879
Breyer, J., Eckstein, M., Sikic, D., Wezel, F., Roghmann, F., Brehmer, M.,... Kriegmair, M.C. (2023). Xpert bladder cancer monitor to predict the need for a second TURB (MoniTURB trial). Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-42088-z
Bühler, A., Brown, E., Paulus, L.-P., Eckstein, M., Thoma, O.-M., Oraiopoulou, M.-E.,... Regensburger, A. (2023). Transrectal Absorber Guide Raster-Scanning Optoacoustic Mesoscopy for Label-Free In Vivo Assessment of Colitis. Advanced Science. https://doi.org/10.1002/advs.202300564
Chiriac, M.-T., Hracsko, Z., Günther, C., Gonzalez Acera, M., Atreya, R., Stolzer, I.,... Neurath, M. (2023). IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling. Gut. https://doi.org/10.1136/gutjnl-2023-329628
Claps, F., van de Kamp, M.W., Mayr, R., Bostrom, P.J., Shariat, S.F., Hippe, K.,... van Rhijn, B.W.G. (2023). Prognostic impact of variant histologies in urothelial bladder cancer treated with radical cystectomy. Bju International. https://doi.org/10.1111/bju.15984
Daunke, T., Beckinger, S., Rahn, S., Krüger, S., Heckl, S., Schäfer, H.,... Sebens, S. (2023). Expression and role of the immune checkpoint regulator PD-L1 in the tumor-stroma interplay of pancreatic ductal adenocarcinoma. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1157397
Demleitner, M., Erlenbach-Wünsch, K., Coras, R., Erber, R., Polifka, I., Eyüpoglu, I.Y.,... Agaimy, A. (2023). Lung cancer presenting with central nervous system metastasis: Clinicopathological and molecular analysis of 171 cases. Annals of Diagnostic Pathology, 63. https://doi.org/10.1016/j.anndiagpath.2022.152082
Dörrich, M., Hecht, M., Fietkau, R., Hartmann, A., Iro, H., Gostian, A.-O.,... Kist, A. (2023). Explainable convolutional neural networks for assessing head and neck cancer histopathology. Diagnostic Pathology, 18(1). https://doi.org/10.1186/s13000-023-01407-8
Eckstein, M., Matek, C., Wagner, P., Erber, R., Büttner-Herold, M., Wild, P.J.,... Bertz, S. (2023). Corrigendum to "Proposal for a Novel Histological Scoring System as a Potential Grading Approach for Muscle-invasive Urothelial Bladder Cancer Correlating with Disease Aggressiveness and Patient Outcomes" [European Urology Oncology (2023)]. European Urology Oncology, 6(6). https://doi.org/10.1016/j.euo.2023.09.023
Erlmeier, F., Sun, N., Shen, J., Feuchtinger, A., Buck, A., Prade, V.M.,... Walch, A. (2023). Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging: Diagnostic Pathways and Metabolites for Renal Tumor Entities. Oncology, 101(2), 126-133. https://doi.org/10.1159/000526436
Erlmeier, F., Zschäbitz, S., Mikuteit, M., Autenrieth, M., Weichert, W., Hartmann, A., & Steffens, S. (2023). The role of claudin-6 in chromophobe renal cell carcinoma. Histology and Histopathology, 38(4), 403-407. https://doi.org/10.14670/HH-18-520
Erlmeier, M., Mikuteit, M., Zschaebitz, S., Autenrieth, M., Weichert, W., Hartmann, A.,... Erlmeier, F. (2023). Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma. BMC Urology, 23(1). https://doi.org/10.1186/s12894-023-01263-0
Fasching, P., Hein, A., Kolberg, H.C., Häberle, L., Uhrig, S., Rübner, M.,... Untch, M. (2023). Pembrolizumab in combination with nab-paclitaxel for the treatment of patients with early-stage triple-negative breast cancer – A single-arm phase II trial (NeoImmunoboost, AGO-B-041). European Journal of Cancer, 184, 1-9. https://doi.org/10.1016/j.ejca.2023.01.001
Firmbach, D., Benz, M., Kuritcyn, P., Bruns, V., Lang-Schwarz, C., Stübs, F.,... Geppert, C.-I. (2023). Tumor–Stroma Ratio in Colorectal Cancer—Comparison between Human Estimation and Automated Assessment. Cancers, 15(10). https://doi.org/10.3390/cancers15102675
Foersch, S., Glasner, C., Woerl, A.-C., Eckstein, M., Wagner, D.-C., Schulz, S.,... Jesinghaus, M. (2023). Multistain deep learning for prediction of prognosis and therapy response in colorectal cancer. Nature Medicine, 29(2), 430-439. https://doi.org/10.1038/s41591-022-02134-1
Gaisa, N.T., Hartmann, A., & Knuechel-Clarke, R. (2023). [New WHO classification 2022: urinary bladder cancer]. Die Pathologie, 44(2), 139-148. https://doi.org/10.1007/s00292-023-01183-8
Grünwald, V., Ivanyi, P., Zschäbitz, S., Wirth, M., Staib, P., Schostak, M.,... Grüllich, C. (2023). Nivolumab Switch Maintenance Therapy After Tyrosine Kinase Inhibitor Induction in Metastatic Renal Cell Carcinoma: A Randomized Clinical Trial by the Interdisciplinary Working Group on Renal Tumors of the German Cancer Society (NIVOSWITCH; AIO-NZK-0116ass). European Urology. https://doi.org/10.1016/j.eururo.2023.09.004
Hartmann, P., Trufa, D., Hohenberger, K., Tausche, P., Trump, S., Mittler, S.,... Neurath-Finotto, S. (2023). Contribution of serum lipids and cholesterol cellular metabolism in lung cancer development and progression. Scientific Reports, 13(1), 5662-. https://doi.org/10.1038/s41598-023-31575-y
Heger, L., Hatscher, L., Liang, C., Lehmann, C., Amon, L., Lühr, J.J.,... Dudziak, D. (2023). XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors. Proceedings of the National Academy of Sciences of the United States of America, 120(33), e2300343120. https://doi.org/10.1073/pnas.2300343120
Heinlein, L., Benz, M., Kuritcyn, P., Bruns, V., Hartmann, A., Geppert, C.-I.,... Wittenberg, T. (2023). Lymph node metastases detection in Whole Slide Images using prototypical patterns and transformer-guided multiple instance learning. Current Directions in Biomedical Engineering, 9(1), 166-169. https://doi.org/10.1515/cdbme-2023-1042
Kang, E.Y., Weir, A., Meagher, N.S., Farrington, K., Nelson, G.S., Ghatage, P.,... Köbel, M. (2023). CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study. Cancer, 129(5), 697-713. https://doi.org/10.1002/cncr.34582
Kletzander, R., Kuritcyn, P., Bruns, V., Benz, M., Eckstein, M., Geppert, C.-I., & Hartmann, A. (2023). Domain Transfer in Histopathology using Multi-ProtoNets with Interactive Prototype Adaptation. Current Directions in Biomedical Engineering, 9(1), 491-494. https://doi.org/10.1515/cdbme-2023-1123
Krug, J., Rodrian, G., Petter, K., Yang, H., Khoziainova, S., Guo, W.,... Britzen-Laurent, N. (2023). N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy. Gastroenterology. https://doi.org/10.1053/j.gastro.2022.11.018
Köbel, M., Kang, E.-Y., Weir, A., Rambau, P.F., Lee, C.-H., Nelson, G.S.,... Brenton, J.D. (2023). p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study. Journal of Pathology: Clinical Research, 9(3), 208-222. https://doi.org/10.1002/cjp2.311
Lang-Schwarz, C., Büttner-Herold, M., Burian, S., Erber, R., Hartmann, A., Jesinghaus, M.,... Bertz, S. (2023). Morphological subtypes of colorectal low-grade intraepithelial neoplasia: Diagnostic reproducibility, frequency and clinical impact. Journal of Clinical Pathology. https://doi.org/10.1136/jcp-2023-209206
Mikuteit, M., Zschäbitz, S., Stoehr, C., Herrmann, E., Polifka, I., Agaimy, A.,... Steffens, S. (2023). Evaluation of Gas 6 as a Prognostic Marker in Papillary Renal Cell Carcinoma. Urologia Internationalis. https://doi.org/10.1159/000529898
Mink, J.N., Khalmurzaev, O., Pryalukhin, A., Geppert, C.-I., Lohse, S., Bende, K.,... Junker, K. (2023). Evaluation of Prognostic Parameters to Identify Aggressive Penile Carcinomas. Cancers, 15(19). https://doi.org/10.3390/cancers15194748
Mink, J.N., Khalmurzaev, O., Pryalukhin, A., Hölters, S., Geppert, C.-I., Lohse, S.,... Junker, K. (2023). Bedeutung von HPV-Status und p16 für die Prognose des Peniskarzinoms. Aktuelle Urologie, 54(4), 274-284. https://doi.org/10.1055/a-2104-1270
Mlecnik, B., Lugli, A., Bindea, G., Marliot, F., Bifulco, C., Lee, J.K.J.,... Galon, J. (2023). Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer. Cancers, 15(2). https://doi.org/10.3390/cancers15020418
Naschberger, E., Fuchs, M., Dickel, N., Kunz, M., Popp, B., Anchang, C.G.,... Stürzl, M. (2023). Tumor microenvironment-dependent epigenetic imprinting in the vasculature predicts colon cancer outcome. Cancer Communications. https://doi.org/10.1002/cac2.12489
Niederreiter, J., Eck, C., Ries, T., Hartmann, A., Märkl, B., Büttner-Herold, M.,... Daniel, C. (2023). Corrigendum: Complement activation via the lectin and alternative pathway in patients with severe COVID-19(Front. Immunol., (2022), 13, (835156), 10.3389/fimmu.2022.835156). Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1294153
Pöschke, P., Fasching, P., Adler, W., Rübner, M., Beckmann, M., Hack, C.,... Gaß, P. (2023). Clinical Characteristics and Prognosis of HER2-0 and HER2-Low-Positive Breast Cancer Patients: Real-World Data from Patients Treated with Neoadjuvant Chemotherapy. Cancers, 15(19). https://doi.org/10.3390/cancers15194678
Ranjan, R.A., Muenzner, J.K., Kunze, P., Geppert, C.-I., Rübner, M., Hübner, H.,... Schneider-Stock, R. (2023). The Chorioallantoic Membrane Xenograft Assay as a Reliable Model for Investigating the Biology of Breast Cancer. Cancers, 15(6). https://doi.org/10.3390/cancers15061704
Rath, T., Atreya, R., Bodenschatz, J., Uter, W., Geppert, C.-I., Vitali, F.,... Neurath, M. (2023). Intestinal Barrier Healing Is Superior to Endoscopic and Histologic Remission for Predicting Major Adverse Outcomes in Inflammatory Bowel Disease: The Prospective ERIca Trial. Gastroenterology, 164(2), 241-255. https://doi.org/10.1053/j.gastro.2022.10.014
Rath, T., Atreya, R., Bodenschatz, J., Uter, W., Geppert, C.-I., Vitali, F.,... Neurath, M. (2023). Healing of the epithelial barrier in the ileum is superior to endoscopic and histologic remission for predicting major adverse outcomes in ulcerative colitis. Frontiers in Medicine, 10. https://doi.org/10.3389/fmed.2023.1221449
Rubin, M.A., Amin, M.B., Compérat, E., Gill, A., Hartmann, A., Menon, S.,... Netto, G.J. (2023). Reply to Yongbao Wei, Haijian Huang, and Liefu Ye's Letter to the Editor re: George J. Netto, Mahul B. Amin, Daniel M. Berney, et al. The 2022 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs—Part B: Prostate and Urinary Tract Tumors. Eur Urol. 2022;82:469–82. European Urology, 83(1), e16-e17. https://doi.org/10.1016/j.eururo.2022.09.021
Rüschoff, J., Schildhaus, H.U., Rüschoff, J.H., Jöhrens, K., Bocker Edmonston, T., Dietmaier, W.,... Büttner, R. (2023). Testing for deficient mismatch repair and microsatellite instability: A focused update. Die Pathologie, 44, 61-70. https://doi.org/10.1007/s00292-023-01208-2
Rüschoff, J., Schildhaus, H.U., Rüschoff, J.H., Jöhrens, K., Bocker-Edmonston, T., Dietmaier, W.,... Büttner, R. (2023). Erratum zu: Testung auf Mismatch-Reparatur-Defizienz und Mikrosatelliteninstabilität: Eine fokussierte Aktualisierung (Die Pathologie, (2023), 44, 5, (301-310), 10.1007/s00292-023-01209-1). Die Pathologie. https://doi.org/10.1007/s00292-023-01226-0
Rüschoff, J., Schildhaus, H.U., Rüschoff, J.H., Jöhrens, K., Bocker-Edmonston, T., Dietmaier, W.,... Büttner, R. (2023). Testing deficient mismatch repair and microsatellite instability: A focused update. German version Testung auf Mismatch-Reparatur-Defizienz und Mikrosatelliteninstabilität: Eine fokussierte Aktualisierung. Die Pathologie. https://doi.org/10.1007/s00292-023-01209-1
Schulmeyer, C., Fasching, P., Häberle, L., Meyer, J., Schneider, M., Wachter, D.,... Gaß, P. (2023). Expression of the Immunohistochemical Markers CK5, CD117, and EGFR in Molecular Subtypes of Breast Cancer Correlated with Prognosis. Diagnostics, 13(3). https://doi.org/10.3390/diagnostics13030372
Schulmeyer, C., Koch, M.C., Dietl, A., Stübs, F., Behrens, A., Renner, S.K.,... Gaß, P. (2023). Standardized Procedures for Patients with Dysplasia and Other Diseases of the Cervix, Vulva, and Vagina at a Certified Dysplasia Unit Prior to the Introduction of the Organized Cervical Cancer Screening Program. Geburtshilfe und Frauenheilkunde, 83(8), 1031-1042. https://doi.org/10.1055/a-1934-1686
Sommer, J., Ehnis, H., Seitz, T., Schneider, J., Wild, A., Moceri, S.,... Hellerbrand, C. (2023). Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity. International Journal of Molecular Sciences, 24(19). https://doi.org/10.3390/ijms241914943
Soteriou, D., Kubankova, M., Schweitzer, C., Lopez Posadas, R., Pradhan, R., Thoma, O.-M.,... Guck, J. (2023). Rapid single-cell physical phenotyping of mechanically dissociated tissue biopsies. Nature Biomedical Engineering. https://doi.org/10.1038/s41551-023-01015-3
Spoerl, S., Erber, R., Gerken, M., Taxis, J., Ludwig, N., Nieberle, F.,... Spörl, S. (2023). A20 as a Potential New Tool in Predicting Recurrence and Patient’s Survival in Oral Squamous Cell Carcinoma. Cancers, 15(3). https://doi.org/10.3390/cancers15030675
Stübs, F., Dietl, A., Koch, M.C., Adler, W., Geppert, C.-I., Hartmann, A.,... Gaß, P. (2023). Cytology and HPV Co-Testing for Detection of Vaginal Intraepithelial Neoplasia: A Retrospective Study. Cancers, 15(18). https://doi.org/10.3390/cancers15184633
Stübs, F., Koch, M.C., Dietl, A., Schulmeyer, C., Behrens, A., Seibold, A.,... Mehlhorn, G. (2023). Management of Cervical Intraepithelial Neoplasia in Pregnant Women. Anticancer Research, 43(7), 3153-3158. https://doi.org/10.21873/anticanres.16488
Tögel, L., Schubart, C., Lettmaier, S., Neufert, C., Hoyer, J., Wolff, K.,... Spörl, S. (2023). Determinants Affecting the Clinical Implementation of a Molecularly Informed Molecular Tumor Board Recommendation: Experience from a Tertiary Cancer Center. Cancers, 15(24). https://doi.org/10.3390/cancers15245892
Wang, H., Stehr, A., Singh, J., Zlatar, L., Hartmann, A., Evert, K.,... Herrmann, M. (2023). Anti-DNA-IgM Favors the Detection of NET-Associated Extracellular DNA. International Journal of Molecular Sciences, 24(4). https://doi.org/10.3390/ijms24044101
Wang, X., Liu, J., Azoitei, A., Eiseler, T., Meessen, S., Jiang, W.,... Günes, C. (2023). Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics. Cellular and Molecular Life Sciences, 80(10). https://doi.org/10.1007/s00018-023-04959-6
Weber, S., Sitte, S., Vögele, A.-L., Sologub, L., Wilfer, A., Rath, T.,... Atreya, R. (2023). NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases. Journal of Crohns & Colitis. https://doi.org/10.1093/ecco-jcc/jjad164
Willner, A., Agaimy, A., Fechner, K., Ott, O., Denz, A., Weissmann, T.,... Semrau, S. (2023). Chemoradiotherapy plus hyperthermia (CRTH) versus chemoradiotherapy (CRT) alone in neoadjuvant treatment of soft tissue sarcoma: tumor response, treatment toxicity and disease control. International Journal of Hyperthermia, 40(1). https://doi.org/10.1080/02656736.2023.2248424
Yang, H., Hübner, K., Hampel, C., Erlenbach-Wünsch, K., Selvamani, S.B., Shukla, V.,... Schneider-Stock, R. (2023). ATF2 loss promotes 5-FU resistance in colon cancer cells via activation of the ATR-Chk1 damage response pathway. BMC Cancer, 23(1). https://doi.org/10.1186/s12885-023-10940-0
Zhang, R., Shi, K., Hohenforst-Schmidt, W., Steppert, C., Sziklavari, Z., Schmidkonz, C.,... Förster, S. (2023). Ability of 18F-FDG Positron Emission Tomography Radiomics and Machine Learning in Predicting KRAS Mutation Status in Therapy-Naive Lung Adenocarcinoma. Cancers, 15(14). https://doi.org/10.3390/cancers15143684
Öttl, M., Steenpaß, J., Rübner, M., Geppert, C.-I., Qiu, J., Wilm, F.,... Breininger, K. (2023). Improved HER2 Tumor Segmentation with Subtype Balancing Using Deep Generative Networks. In Proceedings - International Symposium on Biomedical Imaging. Cartagena, CO: IEEE Computer Society.

2022

Agaimy, A., Clarke, B.A., Kolin, D.L., Lee, C.-H., Lee, J.-C., Mccluggage, W.G.,... Dickson, B.C. (2022). Recurrent KAT6B/A::KANSL1 Fusions Characterize a Potentially Aggressive Uterine Sarcoma Morphologically Overlapping With Low-grade Endometrial Stromal Sarcoma. American Journal of Surgical Pathology, 46(9), 1298-1308. https://doi.org/10.1097/PAS.0000000000001915
Agaimy, A., Haller, F., Renner, A., Niedermeyer, J., Hartmann, A., & French, C.A. (2022). Misleading Germ Cell Phenotype in Pulmonary NUT Carcinoma Harboring the ZNF532-NUTM1 Fusion. American Journal of Surgical Pathology, 46(2), 281-288. https://doi.org/10.1097/PAS.0000000000001774
Agaimy, A., Ihrler, S., Baneckova, M., Martineau, V.C., Mantsopoulos, K., Hartmann, A.,... Skalova, A. (2022). HMGA2-WIF1 Rearrangements Characterize a Distinctive Subset of Salivary Pleomorphic Adenomas With Prominent Trabecular (Canalicular Adenoma-like) Morphology. American Journal of Surgical Pathology, 46(2), 190-199. https://doi.org/10.1097/PAS.0000000000001783
Ahrens, M., Escudier, B., Haanen, J., Gross-Goupil, M., Boleti, E., Gravis, G.,... Bergmann, L. (2022). A randomized phase II trial of ipilimumab and nivolumab versus standard of care in previously untreated and advanced non-clear cell renal cell carcinoma (SUNNIFORECAST). In ONCOLOGY RESEARCH AND TREATMENT (pp. 317-318). BASEL: KARGER.
Alaghehbandan, R., Agaimy, A., Ali, L., Alvarado-Cabrero, I., Amin, M.B., Boudova, L.,... Michal, M. (2022). A tribute to Prof. Ondrej Hes, MD, PhD (1968-2022). Modern Pathology, 35(12), 2023-2024. https://doi.org/10.1038/s41379-022-01159-8
Alfer, J., Fattahi, A., Bleisinger, N., Antoniadis, S., Krieg, J., Dittrich, R.,... Tremellen, K. (2022). Individual dynamics of uterine natural killer cells in natural and stimulated cycles monitored using a new endometrial dating method. American Journal of Reproductive Immunology. https://doi.org/10.1111/aji.13620
Beck, M., Hartwich, J., Eckstein, M., Schmidt, D., Gostian, A.-O., Müller-Hübner, S.,... Semrau, S. (2022). F18-FDG PET/CT imaging early predicts pathologic complete response to induction chemoimmunotherapy of locally advanced head and neck cancer: preliminary single-center analysis of the checkrad-cd8 trial. Annals of Nuclear Medicine. https://doi.org/10.1007/s12149-022-01744-6
Beck, M., Semrau, S., Haderlein, M., Gostian, A.-O., Hartwich, J., Müller, S.K.,... Hecht, M. (2022). Differences and Similarities in the Pattern of Early Metabolic and Morphologic Response after Induction Chemo-Immunotherapy versus Induction Chemotherapy Alone in Locally Advanced Squamous Cell Head and Neck Cancer. Cancers, 14(19). https://doi.org/10.3390/cancers14194811
Berney, D.M., Cree, I., Rao, V., Moch, H., Srigley, J.R., Tsuzuki, T.,... Tickoo, S.K. (2022). An introduction to the WHO 5th edition 2022 classification of testicular tumours. Histopathology. https://doi.org/10.1111/his.14675
Bley, I.A., Zwick, A., Hans, M.C., Thieser, K., Wagner, V., Ludwig, N.,... Lohse, S. (2022). IDKK1 inhibits canonical Wnt signaling in human papillomavirus-positive penile cancer cells. Translational Oncology, 15(1). https://doi.org/10.1016/j.tranon.2021.101267
Brunner, M., Kovacevic, J., Krautz, C., Merkel, S., Hartmann, A., Grützmann, R.,... Weber, G. (2022). Analysis of Intraoperative Frozen Pancreatic Resection Margin and Prediction of Postoperative Pancreatic Fistula Risk During Pancreatoduodenectomy. Journal of the American College of Surgeons, 234(5), 928-937. https://doi.org/10.1097/XCS.0000000000000142
Bueno-Fortes, S., Muenzner, J.K., Berral-Gonzalez, A., Hampel, C., Lindner, P., Berninger, A.,... Schneider-Stock, R. (2022). A gene signature derived from the loss of cdkn1a (P21) is associated with CMS4 colorectal cancer. Cancers, 14(1). https://doi.org/10.3390/cancers14010136
Buettner, F.A., Winter, S., Stuehler, V., Rausch, S., Hennenlotter, J., Füssel, S.,... Schaeffeler, E. (2022). A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy. Genome Medicine, 14(1). https://doi.org/10.1186/s13073-022-01105-y
Busenhart, P., Montalban-Arques, A., Katkeviciute, E., Morsy, Y., Van Passen, C., Hering, L.,... Scharl, M. (2022). Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer. Journal for ImmunoTherapy of Cancer, 10(2). https://doi.org/10.1136/jitc-2021-003465
Chlopek, M., Lasota, J., Thompson, L.D.R., Szczepaniak, M., Kuzniacka, A., Hincza, K.,... Miettinen, M. (2022). Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of the literature. Modern Pathology. https://doi.org/10.1038/s41379-022-01122-7
Curelea, S., Hartmann, A., & Varnai-Haendel, A. (2022). Die Akkreditierung in der Pathologie und Neuropathologie in Deutschland: Rahmenbedingungen und Voraussetzungen. Die Pathologie. https://doi.org/10.1007/s00292-022-01097-x
Dexl, J., Benz, M., Kuritcyn, P., Wittenberg, T., Bruns, V., Geppert, C.-I.,... Goschenhofer, J. (2022). Robust Colon Tissue Cartography with Semi-Supervision. Current Directions in Biomedical Engineering, 8(2), 344-347. https://doi.org/10.1515/cdbme-2022-1088
Dietl, A., Stübs, F., Schulmeyer, C., Behrens, A., Hartmann, A., Agaimy, A.,... Gaß, P. (2022). Rare Case Report - Mucoepidermoid Carcinoma (MEC) of the Vulva. In GEBURTSHILFE UND FRAUENHEILKUNDE (pp. E60-E61). STUTTGART: GEORG THIEME VERLAG KG.
Diez, S., Besendörfer, M., Weyerer, V., Hartmann, A., Moosmann, J., Weiss, C.,... Müller, H. (2022). DMBT1 expression and neutrophil-to-lymphocyte ratio during necrotizing enterocolitis are influenced by impaired perfusion due to cardiac anomalies. Molecular and Cellular Pediatrics, 9(1). https://doi.org/10.1186/s40348-021-00133-9
Diez, S., Renner, M., Bahlinger, V., Hartmann, A., Besendörfer, M., & Müller, H. (2022). Increased expression of OLFM4 and lysozyme during necrotizing enterocolitis in neonates: an observational research study. BMC Pediatrics, 22(1). https://doi.org/10.1186/s12887-022-03260-y
Ehrsam, C., Rechenauer, T., Allabauer, I., Siebenlist, G., Kaspar, S., Rieger, D.,... Hörning, A. (2022). Mucosal Mast Cell Distribution in the Gastrointestinal Tract of Children: A Preliminary Study for Establishing Reference Values. Journal of Pediatric Gastroenterology and Nutrition, 74(1), 46-53. https://doi.org/10.1097/MPG.0000000000003338
Erber, R., Angeloni, M., Stöhr, R., Lux, M.P., Ulbrich-Gebauer, D., Pelz, E.,... Hartmann, A. (2022). Molecular Subtyping of Invasive Breast Cancer Using a PAM50-Based Multigene Expression Test-Comparison with Molecular-Like Subtyping by Tumor Grade/Immunohistochemistry and Influence on Oncologist's Decision on Systemic Therapy in a Real-World Setting. International Journal of Molecular Sciences, 23(15). https://doi.org/10.3390/ijms23158716
Erber, R., Spoerl, S., Mamilos, A., Krupar, R., Hartmann, A., Rübner, M.,... Spörl, S. (2022). Impact of spatially heterogeneous trop‐2 expression on prognosis in oral squamous cell carcinoma. International Journal of Molecular Sciences, 23(1). https://doi.org/10.3390/ijms23010087
Erlmeier, F., Bruecher, B., Stoehr, C., Herrmann, E., Polifka, I., Agaimy, A.,... Steffens, S. (2022). cMET: a prognostic marker in papillary renal cell carcinoma? Human Pathology, 121, 1-10. https://doi.org/10.1016/j.humpath.2021.12.007
Erlmeier, F., Klümper, N., Landgraf, L., Strissel, P., Strick, R., Sikic, D.,... Eckstein, M. (2022). Spatial Immunephenotypes of Distant Metastases but not Matched Primary Urothelial Carcinomas Predict Response to Immune Checkpoint Inhibition. European Urology. https://doi.org/10.1016/j.eururo.2022.10.020
Erlmeier, F., Sun, N., Shen, J., Feuchtinger, A., Buck, A., Prade, V.M.,... Walch, A. (2022). MALDI Mass Spectrometry Imaging—Prognostic Pathways and Metabolites for Renal Cell Carcinomas. Cancers, 14(7). https://doi.org/10.3390/cancers14071763
Fichte, A., Neumann, A.-D., Weigelt, K., Guzman, J., Jansen, T., Keinert, J.,... Lieb, V. (2022). Combined miR-486 and GP88 (Progranulin) Serum Levels Are Suggested as Supportive Biomarkers for Therapy Decision in Elderly Prostate Cancer Patients. Life, 12(5). https://doi.org/10.3390/life12050732
Gaß, P., Kailayangiri, S., Hübner, H., Rübner, M., Hartmann, A., Häberle, L.,... Erber, R. (2022). Expression of disialoganglioside GD2 in breast cancer subtypes. In ONCOLOGY RESEARCH AND TREATMENT (pp. 20-20). BASEL: KARGER.
Gersmann, A.K., Haller, F., Behnert, N., Richter, A., Stöhr, R., Hartmann, A.,... Bremmer, F. (2022). Primary pseudomyogenic haemangioendothelioma of the testis with a novel POTEI::FOSB gene fusion. Histopathology. https://doi.org/10.1111/his.14697
Grünwald, V., Hilser, T., Meiler, J., Goebell, P., Ivanyi, P., Strauss, A.,... Bergmann, L. (2022). A Prospectivly Randomized Phase-II Trial of Axitinib versus Everolimus as Second-Line Therapy in Metastatic Renal Cell Carcinoma (BERAT Study). Oncology Research and Treatment, 45(5), 272-280. https://doi.org/10.1159/000522043
Gähler, A., Trufa, D., Chiriac, M.-T., Tausche, P., Hohenberger, K., Brunst, A.-K.,... Neurath-Finotto, S. (2022). Glucose-Restricted Diet Regulates the Tumor Immune Microenvironment and Prevents Tumor Growth in Lung Adenocarcinoma. Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.873293
Haj Khalaf, M., Sirbu, H., Hartmann, A., Agaimy, A., Dudek, W., Higaze, M., & Rieker, R. (2022). Spread through Air Spaces (STAS) in Solitary Pulmonary Metastases from Colorectal Cancer (CRC). Thoracic and Cardiovascular Surgeon. https://doi.org/10.1055/s-0042-1757632
Hartan, R., Schnellhardt, S., Büttner-Herold, M., Daniel, C., Hartmann, A., Fietkau, R., & Distel, L. (2022). The Prognostic and Predictive Significance of Tumor-Infiltrating Memory T Cells Is Reversed in High-Risk HNSCC. Cells, 11(12). https://doi.org/10.3390/cells11121960
Hecht, M., Eckstein, M., Kallies, A., Klautke, G., Illmer, T., von der Grün, J.,... Fietkau, R. (2022). Pathologic response after induction chemo-immunotherapy with single or double immune checkpoint inhibition in locally advanced head and neck squamous cell carcinoma (HNSCC): Expansion cohorts of the CheckRad-CD8 trial. In JOURNAL OF CLINICAL ONCOLOGY. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Hecht, M., Eckstein, M., Kallies, A., von der Grün, J., Illmer, T., Klautke, G.,... Fietkau, R. (2022, November). Updated analysis of the phase II CheckRad-CD8 trial: First-line treatment of locally advanced head and neck squamous cell carcinoma with induction chemoimmunotherapy followed by radioimmunotherapy. Poster presentation at 35. Deutscher Krebskongress, Krebsmedizin: Schnittstellen zwischen Innovation und Versorgung, Berlin, DE.
Hecht, M., Eckstein, M., Rutzner, S., von der Grün, J., Illmer, T., Klautke, G.,... Gostian, A.-O. (2022). Induction chemoimmunotherapy followed by CD8+ immune cell-based patient selection for chemotherapy-free radioimmunotherapy in locally advanced head and neck cancer. Journal for ImmunoTherapy of Cancer, 10(1). https://doi.org/10.1136/jitc-2021-003747
Heger, L., Hatscher, L., Lehmann, C., Purbojo, A., Onderka, C., Liang, C.,... Dudziak, D. (2022). Select hyperactivating NLRP3 ligands enhance the TH1-and TH17-inducing potential of human type 2 conventional dendritic cells. In EXPERIMENTAL DERMATOLOGY (pp. E75-E76). HOBOKEN: WILEY.
Hein, A., Kehl, S., Häberle, L., Tiemann, C., Peuker, R., Mereutanu, D.,... Schneider, M. (2022). Prevalence of SARS-CoV-2 in Pregnant Women Assessed by RT-PCR in Franconia, Germany: First Results of the SCENARIO Study (SARS-CoV-2 prEvalence in pregNAncy and at biRth In FrancOnia). Geburtshilfe und Frauenheilkunde, 82(2), 226-234. https://doi.org/10.1055/a-1727-9672
Hilser, T., Gruenwald, V., Bergmann, L., Goebell, P., Strauss, A., Meiler, J.,... Bedke, J. (2022). A prospective, open-label, multicenter, randomized phase II trial: Sequential therapy with BEvacizumab, RAd001 (Everolimus) and AxiTinib in metastatic renal cell carcinoma (mRCC) (BERAT study of the IAG-N). In ONCOLOGY RESEARCH AND TREATMENT (pp. 101-101). BASEL: KARGER.
Hübner, K., Erlenbach-Wünsch, K., Prochazka, J., Sheraj, I., Hampel, C., Mrazkova, B.,... Schneider-Stock, R. (2022). ATF2 loss promotes tumor invasion in colorectal cancer cells via upregulation of cancer driver TROP2. Cellular and Molecular Life Sciences, 79(8). https://doi.org/10.1007/s00018-022-04445-5
Jasinski-Bergner, S., Eckstein, M., Taubert, H., Wach, S., Fiebig, C., Strick, R.,... Seliger, B. (2022). The Human Leukocyte Antigen G as an Immune Escape Mechanism and Novel Therapeutic Target in Urological Tumors. Frontiers in Immunology, 13, 811200-. https://doi.org/10.3389/fimmu.2022.811200
Jonigk, D., Werlein, C., Acker, T., Aepfelbacher, M., Amann, K.U., Baretton, G.,... Boor, P. (2022). Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? Virchows Archiv. https://doi.org/10.1007/s00428-022-03319-2
Junker, K., Hallscheidt, P., Wunderlich, H., & Hartmann, A. (2022). Diagnostics and prognostic evaluation in renal cell tumors: the German S3 guidelines recommendations. World Journal of Urology. https://doi.org/10.1007/s00345-022-03972-x
Kench, J.G., Amin, M.B., Berney, D.M., Compérat, E.M., Cree, I.A., Gill, A.J.,... Srigley, J.R. (2022). WHO Classification of Tumours fifth edition: evolving issues in the classification, diagnosis, and prognostication of prostate cancer. Histopathology. https://doi.org/10.1111/his.14711
Klepper, S., Jung, S., Dittmann, L., Geppert, C.-I., Hartmann, A., Beier, N., & Trollmann, R. (2022). Further Evidence of Neuroprotective Effects of Recombinant Human Erythropoietin and Growth Hormone in Hypoxic Brain Injury in Neonatal Mice. International Journal of Molecular Sciences, 23(15). https://doi.org/10.3390/ijms23158693
Kloker, L.D., Calukovic, B., Benzler, K., Golf, A., Böhm, S., Günther, S.,... Lauer, U.M. (2022). Case report: Immunovirotherapy as a novel add-on treatment in a patient with thoracic NUT carcinoma. Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.995744
Klümper, N., Sikic, D., Saal, J., Buettner, T., Jarczyk, J., Zeuschner, P.,... Eckstein, M. (2022). Early CRP kinetics predict long-term treatment success and favorable outcomes of anti-PD-(L)1 immune checkpoint blockade in metastatic urothelial carcinoma. In ONCOLOGY RESEARCH AND TREATMENT (pp. 12-12). BASEL: KARGER.
Klümper, N., Sikic, D., Saal, J., Büttner, T., Goldschmidt, F., Jarczyk, J.,... Eckstein, M. (2022). C-reactive protein flare predicts response to anti-PD-(L)1 immune checkpoint blockade in metastatic urothelial carcinoma. European Journal of Cancer, 167, 13-22. https://doi.org/10.1016/j.ejca.2022.02.022
Kunze, P., Kreiß, L., Novosadová, V., Roehe, A.V., Steinmann, S., Prochazka, J.,... Schneider-Stock, R. (2022). Multiphoton Microscopy Reveals DAPK1‐Dependent Extracellular Matrix Remodeling in a Chorioallantoic Membrane (CAM) Model. Cancers, 14(10). https://doi.org/10.3390/cancers14102364
Köhler, S., Brandl, L., Strissel, P., Glossner, L., Ekici, A.B., Angeloni, M.,... Strick, R. (2022). Improved Bladder Tumor RNA Isolation from Archived Tissues Using Methylene Blue for Normalization, Multiplex RNA Hybridization, Sequencing and Subtyping. International Journal of Molecular Sciences, 23(18). https://doi.org/10.3390/ijms231810267
Lieb, V., Abdulrahman, A., Weigelt, K., Hauch, S., Gombert, M., Guzman, J.,... Wach, S. (2022). Cell-Free DNA Sequencing Reveals Gene Variants in DNA Damage Repair Genes Associated with Prognosis of Prostate Cancer Patients. Cells, 11(22). https://doi.org/10.3390/cells11223618
Lobo, J., Ohashi, R., Amin, M.B., Berney, D.M., Compérat, E.M., Cree, I.A.,... Moch, H. (2022). WHO 2022 landscape of papillary and chromophobe renal cell carcinoma. Histopathology. https://doi.org/10.1111/his.14700
Lueke, F., Haller, F., Utpatel, K., Krebs, M., Meidenbauer, N., Scheiter, A.,... Kerscher, A. (2022). Recording of the regional Origin Areas of Patients from the Molecular Tumor Board to Identify the "white Spots" in the Service Area - A joint Initiative of the Bavarian CCC WERA Alliance. In ONCOLOGY RESEARCH AND TREATMENT (pp. 14-15). BASEL: KARGER.
Lüke, F., Haller, F., Utpatel, K., Krebs, M., Meidenbauer, N., Scheiter, A.,... Kerscher, A. (2022). Identification of Disparities in Personalized Cancer Care—A Joint Approach of the German WERA Consortium. Cancers, 14(20). https://doi.org/10.3390/cancers14205040
Marcou, M., Hartmann, A., Wullich, B., Apel, H., & Hirsch-Koch, K. (2022). Retrospective histological evaluation of orchiectomy specimens following testicular torsion reveals a 10% incidence of reversible injury. Is it time for a change of strategy? Andrology. https://doi.org/10.1111/andr.13368
Marquardt, A., Richterstetter, M., Taubert, H., Hartmann, A., Wullich, B., Lieb, V.,... Apel, H. (2022). Reduced Recurrence Rates Are Associated with Photodynamic Diagnostics Compared to White Light after Extended Transurethral Resection of Bladder Tumors. Life, 12(5). https://doi.org/10.3390/life12050641
Mayr, R., Eckstein, M., Wirtz, R.M., Santiago-Walker, A., Baig, M., Sundaram, R.,... Breyer, J. (2022). Prognostic and Predictive Value of Fibroblast Growth Factor Receptor Alterations in High-grade Non–muscle-invasive Bladder Cancer Treated with and Without Bacillus Calmette-Guérin Immunotherapy. European Urology. https://doi.org/10.1016/j.eururo.2022.02.028
Menon, S., Moch, H., Berney, D.M., Cree, I.A., Srigley, J.R., Tsuzuki, T.,... Amin, M.B. (2022). WHO 2022 classification of penile and scrotal cancers: updates and evolution. Histopathology. https://doi.org/10.1111/his.14824
Mertens, L.S., Claps, F., Mayr, R., Bostrom, P.J., Shariat, S.F., Zwarthoff, E.C.,... van Rhijn, B.W.G. (2022). Prognostic markers in invasive bladder cancer: FGFR3 mutation status versus P53 and KI-67 expression: a multi-center, multi-laboratory analysis in 1058 radical cystectomy patients. Urologic Oncology-Seminars and Original Investigations, 40(3), 110.e1-110.e9. https://doi.org/10.1016/j.urolonc.2021.10.010
Mikuteit, M., Steffens, S., Zschäbitz, S., Autenrieth, M., Weichert, W., Hartmann, A., & Erlmeier, F. (2022). Trophoblast Cell Surface Antigen 2 (Trop2) in Chromophobe Renal Cell Carcinoma. Oncology, 100(6), 331-336. https://doi.org/10.1159/000522592
Mikuteit, M., Zschäbitz, S., Erlmeier, M., Autenrieth, M., Weichert, W., Hartmann, A.,... Erlmeier, F. (2022). Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma. Oncology, 100(10), 536-541. https://doi.org/10.1159/000525601
Mikuteit, M., Zschäbitz, S., Stöhr, C., Herrmann, E., Polifka, I., Agaimy, A.,... Erlmeier, F. (2022). The prognostic impact of Claudin 6 in papillary renal cell carcinoma. Pathology Research and Practice, 231. https://doi.org/10.1016/j.prp.2022.153802
Mink, J., Khalmurzaev, O., Hoelters, S., Pryalukhin, A., Heinzelbecker, J., Lohse, S.,... Henrique, R. (2022). Clinical and histopathological characterization of penile carcinomas with focus on HPV-status and histological subtype. In ONCOLOGY RESEARCH AND TREATMENT (pp. 96-96). BASEL: KARGER.
Mlecnik, B., Torigoe, T., Bindea, G., Popivanova, B., Xu, M., Fujita, T.,... Galon, J. (2022). Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study. Cancers, 14(18). https://doi.org/10.3390/cancers14184346
Moch, H., Amin, M.B., Berney, D.M., Compérat, E.M., Gill, A.J., Hartmann, A.,... Netto, G.J. (2022). The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours. European Urology. https://doi.org/10.1016/j.eururo.2022.06.016
Mohammed, A., Geppert, C.-I., Hartmann, A., Kuritcyn, P., Bruns, V., Schmid, U.,... Finzel, B. (2022). Explaining and Evaluating Deep Tissue Classification by Visualizing Activations of Most Relevant Intermediate Layers. Current Directions in Biomedical Engineering, 8(2), 229-232. https://doi.org/10.1515/cdbme-2022-1059
Mohr, T., Zwick, A., Hans, M.C., Bley, I.A., Braun, F.L., Khalmurzaev, O.,... Lohse, S. (2022). The prominent role of the S100A8/S100A9-CD147 axis in the progression of penile cancer. Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.891511
Mondorf, Y., Mikuteit, M., Ivanyi, P., Stoehr, C., Herrmann, E., Polifka, I.,... Erlmeier, F. (2022). The Prognostic Impact of PD-L2 in Papillary Renal-Cell Carcinoma. Urologia Internationalis, 106(11), 1168-1176. https://doi.org/10.1159/000525016
Netto, G.J., Amin, M.B., Berney, D.M., Compérat, E.M., Gill, A.J., Hartmann, A.,... Moch, H. (2022). The 2022 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs-Part B: Prostate and Urinary Tract Tumors. European Urology, 82(5), 469-482. https://doi.org/10.1016/j.eururo.2022.07.002
Netto, G.J., Amin, M.B., Compérat, E.M., Gill, A.J., Hartmann, A., Moch, H.,... Berney, D.M. (2022). Prostate Adenocarcinoma Grade Group 1: Rationale for Retaining a Cancer Label in the 2022 World Health Organization Classification. European Urology. https://doi.org/10.1016/j.eururo.2022.09.015
Niederreiter, J., Eck, C., Ries, T., Hartmann, A., Märkl, B., Büttner-Herold, M.,... Daniel, C. (2022). Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.835156
Paner, G.P., Smith, S.C., Hartmann, A., Agarwal, P.K., Comperat, E., & Amin, M.B. (2022). Flat intraurothelial lesions of the urinary bladder-do hyperplasia, dysplasia, and atypia of unknown significance need to exist as diagnostic entities? and how to handle in routine clinical practice. Modern Pathology. https://doi.org/10.1038/s41379-022-01087-7
Prade, V.M., Sun, N., Shen, J., Feuchtinger, A., Kunzke, T., Buck, A.,... Walch, A. (2022). The synergism of spatial metabolomics and morphometry improves machine learning-based renal tumour subtype classification. Clinical and Translational Medicine, 12(2). https://doi.org/10.1002/ctm2.666
Protze, J., Naas, S., Krüger, R., Stöhr, C., Kraus, A., Grampp, S.,... Wiesener, M. (2022). The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression. Journal of Biological Chemistry, 298(3). https://doi.org/10.1016/j.jbc.2022.101699
Schnellhardt, S., Hirneth, J., Büttner-Herold, M., Daniel, C., Haderlein, M., Hartmann, A.,... Distel, L. (2022). The Prognostic Value of FoxP3+Tumour-Infiltrating Lymphocytes in Rectal Cancer Depends on Immune Phenotypes Defined by CD8+Cytotoxic T Cell Density. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.781222
Schrenk, K.G., Weschenfelder, W., Spiegel, C., Agaimy, A., Stöhr, R., Hartmann, A.,... Hochhaus, A. (2022). Exceptional response to neoadjuvant targeted therapy with the selective RET inhibitor selpercatinib in RET-fusion-associated sarcoma. Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-022-04496-y
Schuhwerk, H., Kleemann, J., Gupta, P., van Roey, R., Armstark, I., Kreileder, M.,... Brabletz, T. (2022). The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response. Cell Reports, 41(11). https://doi.org/10.1016/j.celrep.2022.111819
Seitz, J., Hoegel, J., Eckstein, M., Lieb, V., Wullich, B., Hartmann, A., & Rieker, R. (2022). Immunohistochemical analysis of sex hormone receptors in squamous changes of the urothelium. International Journal of Clinical and Experimental Pathology, 15(7), 272-281.
Seitz, J., Hogel, J., Eckstein, M., Lieb, V., Wullich, B., Hartmann, A., & Rieker, R. (2022). Immunohistochemical analysis of sex hormone receptors in squamous changes of the urothelium. International Journal of Clinical and Experimental Pathology, 15(7), 272-281.
Seitz, T., John, N., Sommer, J., Dietrich, P., Thasler, W.E., Hartmann, A.,... Hellerbrand, C. (2022). Role of Fibroblast Growth Factors in the Crosstalk of Hepatic Stellate Cells and Uveal Melanoma Cells in the Liver Metastatic Niche. International Journal of Molecular Sciences, 23(19). https://doi.org/10.3390/ijms231911524
Seliger, B., Jasinski-Bergner, S., Massa, C., Mueller, A., Biehl, K., Yang, B.,... Bauer, M. (2022). Induction of pulmonary HLA-G expression by SARS-CoV-2 infection. Cellular and Molecular Life Sciences, 79(11). https://doi.org/10.1007/s00018-022-04592-9
Singh, J., Herrmann, I., Mahajan, A., Schauer, C., Shan, X., Hartmann, A.,... Knopf, J. (2022). A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19. International Journal of Molecular Sciences, 23(23). https://doi.org/10.3390/ijms232315126
Spörl, S., Erber, R., Gerken, M., Wittenberg, M., Fischer, R., Taxis, J.,... Spoerl, S. (2022). CXCR2 expression on neutrophil granulocytes in peripheral tumor is associated with shorter survival in oral squamous cell carcinoma. In ONCOLOGY RESEARCH AND TREATMENT (pp. 78-78). BASEL: KARGER.
Stübs, F., Dietl, A., Behrens, A., Adler, W., Geppert, C.-I., Hartmann, A.,... Koch, M.C. (2022). Concordance Rate of Colposcopy in Detecting Cervical Intraepithelial Lesions. Diagnostics, 12(10). https://doi.org/10.3390/diagnostics12102436
Stübs, F., Koch, M.C., Dietl, A., Adler, W., Geppert, C.-I., Hartmann, A.,... Schulmeyer, C. (2022). Cytology and hrHPV for cervical cancer screening assessment. In GEBURTSHILFE UND FRAUENHEILKUNDE (pp. E171-E172). STUTTGART: GEORG THIEME VERLAG KG.
Stübs, F., Koch, M.C., Dietl, A., Adler, W., Geppert, C.-I., Hartmann, A.,... Gaß, P. (2022). Cytology and High-Risk Human Papillomavirus Test for Cervical Cancer Screening Assessment. Diagnostics, 12(7). https://doi.org/10.3390/diagnostics12071748
Stübs, F., Mergel, F., Koch, M., Dietl, A., Schulmeyer, C., Adler, W.,... Mehlhorn, G. (2022). Cervical intraepithelial neoplasia grade 3: development during pregnancy and postpartum. Archives of Gynecology and Obstetrics. https://doi.org/10.1007/s00404-022-06815-7
Stübs, F., Mergel, F., Koch, M.C., Dietl, A., Schulmeyer, C., Adler, W.,... Mehlhorn, G. (2022). Cervical intraepithelial neoplasia grade 2/3: development during pregnancy and postpartum. In GEBURTSHILFE UND FRAUENHEILKUNDE (pp. E171-E171). STUTTGART: GEORG THIEME VERLAG KG.
Vitali, F., Morgenstern, N., Eckstein, M., Atreya, R., Waldner, M., Hartmann, A.,... Rath, T. (2022). Endocytoscopy for assessing histologic inflammation in ulcerative colitis: development and prospective validation of the ELECT (ErLangen Endocytoscopy in ColiTis) score (with videos). Gastrointestinal Endoscopy. https://doi.org/10.1016/j.gie.2022.08.023
Vollbrecht, C., Hoffmann, I., Lehmann, A., Merkelbach-Bruse, S., Fassunke, J., Wagener-Ryczek, S.,... Hummel, M. (2022). Proficiency testing of PIK3CA mutations in HR+/HER2-breast cancer on liquid biopsy and tissue. Virchows Archiv. https://doi.org/10.1007/s00428-022-03445-x
Voskens, C., Stoica, D., Rosenberg, M., Vitali, F., Zundler, S., Ganslmayer, M.,... Neurath, M. (2022). Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis. Gut. https://doi.org/10.1136/gutjnl-2022-327075
Wilm, F., Benz, M., Bruns, V., Baghdadlian, S., Dexl, J., Hartmann, D.,... Geppert, C.-I. (2022). Fast whole-slide cartography in colon cancer histology using superpixels and CNN classification. Journal of Medical Imaging, 9(2). https://doi.org/10.1117/1.JMI.9.2.027501
Zhang, R., Hohenforst-Schmidt, W., Steppert, C., Sziklavari, Z., Schmidkonz, C., Atzinger, A.,... Foerster, S. (2022). Standardized 18F-FDG PET/CT radiomic features provide information on PD-L1 expression status in treatment-naive patients with non-small cell lung cancer. Nuklearmedizin-Nuclear Medicine. https://doi.org/10.1055/a-1816-6950
Zschabitz, S., Mikuteit, M., Stoehr, C., Herrmann, E., Polifka, I., Agaimy, A.,... Steffens, S. (2022). Expression of nectin-4 in papillary renal cell carcinoma. Discover Oncology, 13(1). https://doi.org/10.1007/s12672-022-00558-2
Zschaebitz, S., Erlmeier, F., Stoehr, C., Herrmann, E., Polifka, I., Agaimy, A.,... Steffens, S. (2022). Expression of Prostate-specific Membrane Antigen (PSMA) in Papillary Renal Cell Carcinoma - Overview and Report on a Large Multicenter Cohort. Journal of Cancer, 13(5), 1706-1712. https://doi.org/10.7150/jca.63509
von Stillfried, S., Bülow, R.D., Röhrig, R., Boor, P., Böcker, J., Schmidt, J.,... Vogt, N. (2022). First report from the German COVID-19 autopsy registry. The Lancet Regional Health - Europe. https://doi.org/10.1016/j.lanepe.2022.100330
von Stillfried, S., Bülow, R.D., Röhrig, R., Meybohm, P., Boor, P., Böcker, J.,... Vogt, N. (2022). Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report. Critical Care, 26(1). https://doi.org/10.1186/s13054-022-03945-x
Öttl, M., Mönius, J., Marzahl, C., Rübner, M., Geppert, C.-I., Hartmann, A.,... Breininger, K. (2022). Superpixel Pre-segmentation of HER2 Slides for Efficient Annotation. In Klaus Maier-Hein, Thomas M. Deserno, Heinz Handels, Andreas Maier, Christoph Palm, Thomas Tolxdorff (Eds.), Informatik aktuell (pp. 254-259). Heidelberg, DEU: Springer Science and Business Media Deutschland GmbH.

2021

Agaimy, A., Baneckova, M., Ihrler, S., Müller, S.K., Franchi, A., Hartmann, A.,... Skalova, A. (2021). ALK Rearrangements Characterize 2 Distinct Types of Salivary Gland Carcinomas Clinicopathologic and Molecular Analysis of 4 Cases and Literature Review. American Journal of Surgical Pathology, 45(9), 1166-1178. https://doi.org/10.1097/PAS.0000000000001698
Agaimy, A., Daum, O., Michal, M., Schmidt, M.W., Stöhr, R., Hartmann, A., & Lauwers, G.Y. (2021). Undifferentiated large cell/rhabdoid carcinoma presenting in the intestines of patients with concurrent or recent non-small cell lung cancer (NSCLC): clinicopathologic and molecular analysis of 14 cases indicates an unusual pattern of dedifferentiated metastases. Virchows Archiv. https://doi.org/10.1007/s00428-021-03032-6
Agaimy, A., & Hartmann, A. (2021). SMARCB1(INI1)-deficient renal cell carcinoma: medullary and beyond Evolving concepts. Pathologe. https://doi.org/10.1007/s00292-021-00985-y
Agaimy, A., Hartmann, A., Trpkov, K., & Hes, O. (2021). Undifferentiated and dedifferentiated urological carcinomas: lessons learned from the recent developments. Seminars in Diagnostic Pathology. https://doi.org/10.1053/j.semdp.2021.09.004
Agaimy, A., Stöhr, R., Hornung, A., Popp, J., Erdmann, M., Heinzerling, L., & Hartmann, A. (2021). Dedifferentiated and Undifferentiated Melanomas: Report of 35 New Cases with Literature Review and Proposal of Diagnostic Criteria. American Journal of Surgical Pathology, 45(2), 240-254. https://doi.org/10.1097/PAS.0000000000001645
Agaimy, A., Stöhr, R., Otto, M., Braesen, J.H., Pfarr, N., Konukiewitz, B.,... Kloeppel, G. (2021). Intra-abdominal EWSR1/FUS-CREM-rearranged malignant epithelioid neoplasms: two cases of an emerging aggressive entity with emphasis on misleading immunophenotype. Virchows Archiv. https://doi.org/10.1007/s00428-021-03140-3
Agaimy, A., Tögel, L., Stöhr, R., Meidenbauer, N., Semrau, S., Hartmann, A., & Mantsopoulos, K. (2021). NSD3-NUTM1-rearranged carcinoma of the median neck/thyroid bed developing after recent thyroidectomy for sclerosing mucoepidermoid carcinoma with eosinophilia: report of an extraordinary case. Virchows Archiv. https://doi.org/10.1007/s00428-021-03103-8
Ahrens, M., Escudier, B., Haanen, J.B.A.G., Boleti, E., Goupil, G.M., Grimm, M.O.,... Bergmann, L. (2021). An ongoing, randomized phase II study of Nivolumab plus Ipilimumab versus standard of care in previously untreated and advanced non-clear cell renal cell carcinoma (SUNIFORECAST). In ONCOLOGY RESEARCH AND TREATMENT (pp. 74-75). BASEL: KARGER.
Alfer, J., Popovici, R.M., Fattahi, A., Krieg, J., Dittrich, R., Beckmann, M.,... Bleisinger, N. (2021). Endometrial delay is found to be part of a normal individual dynamic transformation process. Archives of Gynecology and Obstetrics. https://doi.org/10.1007/s00404-021-06086-8
Ali, N., Bolenz, C., Todenhöfer, T., Stenzel, A., Deetmar, P., Kriegmair, M.,... Bocklitz, T. (2021). Deep learning-based classification of blue light cystoscopy imaging during transurethral resection of bladder tumors. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-91081-x
Amann, K.U., Boor, P., Wiech, T., Singh, J., Vonbrunn, E., Knöll, A.,... Hartmann, A. (2021). COVID-19 effects on the kidney. Pathologe, 42(Suppl 1), 76-80. https://doi.org/10.1007/s00292-020-00900-x
Amann, K.U., Boor, P., Wiech, T., Singh, J., Vonbrunn, E., Knöll, A.,... Hartmann, A. (2021). COVID-19 effects on the kidney. Pathologe. https://doi.org/10.1007/s00292-020-00899-1
Ayoubian, H., Heinzelmann, J., Hölters, S., Khalmurzaev, O., Pryalukhin, A., Loertzer, P.,... Junker, K. (2021). Mirna expression characterizes histological subtypes and metastasis in penile squamous cell carcinoma. Cancers, 13(6). https://doi.org/10.3390/cancers13061480
Bergmann, L., Weber, S., Hartmann, A., & Ahrens, M. (2021). Pathology and systemic therapy of non-clear cell renal cell carcinoma: an overview. Expert Review of Anticancer Therapy. https://doi.org/10.1080/14737140.2021.1959319
Bernhard, M.C., Zwick, A., Mohr, T., Gasparoni, G., Khalmurzaev, O., Matveev, V.B.,... Lohse, S. (2021). The HPV and p63 status in penile cancer are linked with the infiltration and therapeutic availability of neutrophils. Molecular Cancer Therapeutics, 20(2), 423-437. https://doi.org/10.1158/1535-7163.MCT-20-0173
Bertz, S., Angeloni, M., Drgac, J., Falkeis, C., Lang-Schwarz, C., Sterlacci, W.,... Vieth, M. (2021). Helicobacter infection and gastric adenoma. Microorganisms, 9(1), 1-22. https://doi.org/10.3390/microorganisms9010108
Bieg, M., Moskalev, E., Will, R., Hebele, S., Schwarzbach, M., Schmeck, S.,... Haller, F. (2021). Gene Expression in Solitary Fibrous Tumors (SFTs) Correlates with Anatomic Localization and NAB2-STAT6 Gene Fusion Variants. American Journal of Pathology, 191(4), 602-617. https://doi.org/10.1016/j.ajpath.2020.12.015
Boor, P., Eichhorn, P., Hartmann, A., Lax, S.F., Märkl, B., Menter, T.,... Weirich, G. (2021). Praktische Aspekte von COVID-19-Obduktionen. Pathologe, 42(2), 197-207. https://doi.org/10.1007/s00292-021-00925-w
Claps, F., Van De Kamp, M.W., Mayr, R., Bostrom, P.J., Boormans, J.L., Eckstein, M.,... van Rhijn, B.W.G. (2021). Risk factors associated with positive surgical margins’ location at radical cystectomy and their impact on bladder cancer survival. World Journal of Urology. https://doi.org/10.1007/s00345-021-03776-5
Deuschel, J., Firmbach, D., Geppert, C.-I., Eckstein, M., Hartmann, A., Bruns, V.,... Benz, M. (2021). Multi-Prototype Few-shot Learning in Histopathology. In 2021 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW 2021) (pp. 620-628). LOS ALAMITOS: IEEE COMPUTER SOC.
Din, N.U., Fatima, S., Hartmann, A., & Agaimy, A. (2021). Primary renal synovial sarcoma; a clinicopathological study of 19 cases comparing diagnostic utility of SS18-SSX-specific antibody with TLE1. In HISTOPATHOLOGY (pp. 32-32). HOBOKEN: WILEY.
Eckstein, M., Kimmel, C., Bruendl, J., Weber, F., Denzinger, S., Gierth, M.,... Breyer, J. (2021). Tumor budding correlates with discohesive growth pattern, tumor invasiveness and is associated with worse survival of pT1 Non-Muscle-Invasive Bladder Cancer (NMIBC). In EUROPEAN UROLOGY (pp. S620-S620). AMSTERDAM: ELSEVIER.
Eckstein, M., Kimmel, C., Bruendl, J., Weber, F., Denzinger, S., Gierth, M.,... Breyer, J. (2021). Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-97500-3
Eckstein, M., Lieb, V., Jung, R., Sikic, D., Weigelt, K., Stöhr, R.,... Wach, S. (2021). Combination of GP88 Expression in Tumor Cells and Tumor-Infiltrating Immune Cells Is an Independent Prognostic Factor for Bladder Cancer Patients. Cells, 10(7). https://doi.org/10.3390/cells10071796
Erber, R., Hartmann, A., Fasching, P., Rübner, M., Stöhr, R., Beckmann, M.,... Ferrazzi, F. (2021). Reproducibility of mRNA-Based Testing of ESR1, PGR, ERBB2, and MKI67 Expression in Invasive Breast Cancer-A Europe-Wide External Quality Assessment. Cancers, 13(18). https://doi.org/10.3390/cancers13184718
Erber, R., Kailayangiri, S., Hübner, H., Rübner, M., Hartmann, A., Häberle, L.,... Gaß, P. (2021). Variable expression of the disialoganglioside gd2 in breast cancer molecular subtypes. Cancers, 13(21). https://doi.org/10.3390/cancers13215577
Erber, R., Preidl, R., Stöhr, R., Haller, F., Hartmann, A., Kesting, M.R., & Agaimy, A. (2021). DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case. Head and Neck Pathology. https://doi.org/10.1007/s12105-021-01364-y
Farcaş, M., Gatalica, Z., Trpkov, K., Swensen, J., Zhou, M., Alaghehbandan, R.,... Hes, O. (2021). Correction to: Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases (Modern Pathology, (2021), 10.1038/s41379-021-00923-6). Modern Pathology. https://doi.org/10.1038/s41379-021-00967-8
Fasching, P., Yadav, S., Hu, C., Wunderle, M., Häberle, L., Hart, S.N.,... Couch, F.J. (2021). Mutations in BRCA1/2 and Other Panel Genes in Patients With Metastatic Breast Cancer -Association With Patient and Disease Characteristics and Effect on Prognosis. Journal of Clinical Oncology, 39(15), 1619-1630. https://doi.org/10.1200/JCO.20.01200
Foersch, S., Eckstein, M., Wagner, D.C., Gach, F., Woerl, A.C., Geiger, J.,... Roth, W. (2021). Deep learning for diagnosis and survival prediction in soft tissue sarcoma. Annals of Oncology, 32(9), 1178-1187. https://doi.org/10.1016/j.annonc.2021.06.007
Fuchs, T.L., Maclean, F., Turchini, J., Vargas, A.C., Bhattarai, S., Agaimy, A.,... Gill, A.J. (2021). Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients. Modern Pathology. https://doi.org/10.1038/s41379-021-00998-1
Gerber, T.S., Agaimy, A., Hartmann, A., Habekost, M., Roth, W., Stenzinger, A.,... Straub, B.K. (2021). SWI/SNF-deficient undifferentiated/rhabdoid carcinoma of the gallbladder carrying a POLE mutation in a 30-year-old woman: a case report. Diagnostic Pathology, 16(1). https://doi.org/10.1186/s13000-021-01112-4
Gsottberger, F., Brandl, C., Wendland, K., Petkovic, S., Emmerich, C., Erber, R.,... Müller, F. (2021). Human CD22-transgenic, primary murine lymphoma challenges immunotherapies in organ-specific tumor microenvironments. International Journal of Molecular Sciences, 22(19). https://doi.org/10.3390/ijms221910433
Haller, F., Schlieben, L.D., Ferrazzi, F., Michal, M., Stöhr, R., Moskalev, E.,... Agaimy, A. (2021). Lipomatous Solitary Fibrous Tumors Harbor Rare NAB2-STAT6 Fusion Variants and Show Up-Regulation of the Gene PPARG, Encoding for a Regulator of Adipocyte Differentiation. American Journal of Pathology. https://doi.org/10.1016/j.ajpath.2021.03.012
Hartmann, A., & Agaimy, A. (2021). Eosinophiles solide und zystisches Nierenzellkarzinom (ESC-NZK). Pathologe. https://doi.org/10.1007/s00292-021-00998-7
Hartmann, A., & Agaimy, A. (2021). Erratum to: Eosinophilic, solid, and cystic renal cell carcinoma (ESC-RCC) (Der Pathologe, (2021), 42, 6, (565-570), 10.1007/s00292-021-00998-7) Erratum zu: Eosinophiles solide und zystisches Nierenzellkarzinom (ESC-NZK) (Der Pathologe, (2021), 42, 6, (565-570), 10.1007/s00292-021-00998-7). Pathologe. https://doi.org/10.1007/s00292-021-01014-8
Hatscher, L., Lehmann, C., Purbojo, A., Onderka, C., Liang, C., Hartmann, A.,... Dudziak, D. (2021). Select hyperactivating NLRP3 ligands enhance the TH1-and TH17-inducing potential of human type 2 conventional dendritic cells. Science Signaling, 14(680), 1-17. https://doi.org/10.1126/scisignal.abe1757
Hecht, M., Eckstein, M., Rutzner, S., Von Der Gruen, J., Illmer, T., Klautke, G.,... Fietkau, R. (2021). Primary Results of the phase II CheckRad-CD8 Trial: First-Line Treatment of locally advanced Head and Neck Tumors with double Checkpoint Blockade and Radiotherapy dependent on intratumoral CD8+T-Cell Infiltration. In STRAHLENTHERAPIE UND ONKOLOGIE (pp. S9-S10). HEIDELBERG: SPRINGER HEIDELBERG.
Hecht, M., Eckstein, M., Rutzner, S., von der Grün, J., Illmer, T., Klautke, G.,... Fietkau, R. (2021). Primary results of the phase II CheckRad-CD8 trial: First-line treatment of locally advanced head and neck squamous cell carcinoma (HNSCC) with double checkpoint blockade and radiotherapy dependent on intratumoral CD8+T-cell infiltration. In Proceedings of the ASCO 2021 Annual Meeting. online, US: PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Heindl, F., Fasching, P., Hein, A., Hack, C., Heusinger, K., Gaß, P.,... Emons, J. (2021). Mammographic density and prognosis in primary breast cancer patients. BREAST , 59, 51-57. https://doi.org/10.1016/j.breast.2021.06.004
Hellwig, K., Ellmann, S., Eckstein, M., Wiesmüller, M., Rutzner, S., Semrau, S.,... Gostian, A.-O. (2021). Predictive Value of Multiparametric MRI for Response to Single-Cycle Induction Chemo-Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma. Frontiers in Oncology, 11. https://doi.org/10.3389/fonc.2021.734872
Hilgers, L., Hartmann, A., Fasching, P., Villwock, S., Moll, L., Roger, S.,... Dahl, E.D. (2021). Epigenetic regulation of the putative breast cancer metastasis suppressor gene SCN4B. In ANNALS OF ONCOLOGY (pp. S69-S69). AMSTERDAM: ELSEVIER.
Hiresh, A., Heinzelmann, J., Hoelters, S., Khalmurzaev, O., Pryalukhin, A., Loertzer, P.,... Junker, K. (2021). miRNA expression characterizes histological subtypes and metastasis in penile squamous cell carcinoma. In EUROPEAN UROLOGY (pp. S928-S928). AMSTERDAM: ELSEVIER.
Hiß, S., Eckstein, M., Segschneider, P., Mantsopoulos, K., Iro, H., Hartmann, A.,... Müller, S.K. (2021). Tumour‐infiltrating lymphocytes (Tils) and pd‐l1 expression correlate with lymph node metastasis, high‐grade transformation and shorter metastasis‐free survival in patients with acinic cell carcinoma (acicc) of the salivary glands. Cancers, 13(5), 1-14. https://doi.org/10.3390/cancers13050965
Hommerding, O., Allory, Y., Argani, P., Bismar, T.A., Bubendorf, L., Canete-Portillo, S.,... Kristiansen, G. (2021). Molekularpathologie bei urologischen Tumoren: Empfehlungen der Konsenskonferenz der Internationalen Gesellschaft für Uropathologie (ISUP) 2019. Pathologe. https://doi.org/10.1007/s00292-020-00888-4
Jütte, H., Reike, M., Wirtz, R.M., Kriegmair, M., Erben, P., Tully, K.,... Roghmann, F. (2021). Krt20, krt5, esr1 and erbb2 expression can predict pathologic outcome in patients undergoing neoadjuvant chemotherapy and radical cystectomy for muscle-invasive bladder cancer. Journal of Personalized Medicine, 11(6). https://doi.org/10.3390/jpm11060473
Kang, E.-Y., Millstein, J., Popovic, G., Meagher, N.S., Bolithon, A., Talhouk, A.,... Kobel, M. (2021). MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma. Virchows Archiv. https://doi.org/10.1007/s00428-021-03232-0
Kapsner, L., Zavgorodnij, M.G., Majorova, S.P., Hotz-Wagenblatt, A., Kolychev, O.V., Lebedev, I.N.,... Moskalev, E. (2021). BiasCorrector: Fast and accurate correction of all types of experimental biases in quantitative DNA methylation data derived by different technologies. International Journal of Cancer. https://doi.org/10.1002/ijc.33681
Keck, B., Borkowetz, A., Pöllmann, J., Jansen, T., Fischer, M., Fuessel, S.,... Wach, S. (2021). Serum miRNAs Support the Indication for MRI-Ultrasound Fusion-Guided Biopsy of the Prostate in Patients with Low-PI-RADS Lesions. Cells, 10(6). https://doi.org/10.3390/cells10061315
Kullmann, F., Strissel, P., Strick, R., Stöhr, R., Eckstein, M., Bertz, S.,... Weyerer, V. (2021). Frequency of microsatellite instability (MSI) in upper tract urothelial carcinoma: comparison of the Bethesda panel and the Idylla MSI assay in a consecutively collected, multi-institutional cohort. Journal of Clinical Pathology. https://doi.org/10.1136/jclinpath-2021-207855
Kuritcyn, P., Geppert, C.-I., Eckstein, M., Hartmann, A., Wittenberg, T., Dexl, J.,... Benz, M. (2021). Robust Slide Cartography in Colon Cancer Histology: Evaluation on a Multi-scanner Database. In Christoph Palm, Heinz Handels, Klaus Maier-Hein, Thomas M. Deserno, Andreas Maier, Thomas Tolxdorff (Eds.), Informatik aktuell (pp. 229-234). Regensburg, DE: Springer Science and Business Media Deutschland GmbH.
Lang-Schwarz, C., Angeloni, M., Agaimy, A., Atreya, R., Becker, C., Dregelies, T.,... Vieth, M. (2021). Validation of the 'Inflammatory Bowel Disease-Distribution, Chronicity, Activity [IBD-DCA] Score' for Ulcerative Colitis and Crohn ' s Disease. Journal of Crohns & Colitis, 15(10), 1621-1630. https://doi.org/10.1093/ecco-jcc/jjab055
Lang-Schwarz, C., Melcher, B., Hartmann, A., Bertz, S., Dregelies, T., Lang-Schwarz, K.,... Sterlacci, W. (2021). Programmed death ligand 1 (PD-L1) in colon cancer and its interaction with budding and tumor-infiltrating lymphocytes (TILs) as tumor-host antagonists. International Journal of Colorectal Disease. https://doi.org/10.1007/s00384-021-03985-9
Lieb, V., Bellut, L., Abdulrahman, A., Weigelt, K., Hauch, S., Gombert, M.,... Wach, S. (2021). Cell-free dna variant sequencing using plasma and ar-v7 testing of circulating tumor cells in prostate cancer patients. Cells, 10(11). https://doi.org/10.3390/cells10113223
Lindskrog, S.V., Prip, F., Lamy, P., Taber, A., Groeneveld, C.S., Birkenkamp-Demtröder, K.,... Dyrskjøt, L. (2021). An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-22465-w
Mihaela, F., Zoran, G., Kiril, T., Jeffrey, S., Ming, Z., Reza, A.,... Ondrej, H. (2021). Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases. Modern Pathology. https://doi.org/10.1038/s41379-021-00923-6
Morra, A., Escala-Garcia, M., Beesley, J., Keeman, R., Canisius, S., Ahearn, T.U.,... Schmidt, M.K. (2021). Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment. BREAST CANCER RES , 23(1). https://doi.org/10.1186/s13058-021-01450-7
Ohashi, R., Hartmann, A., Martignoni, G., & Moch, H. (2021). Re: Svetlana Avulova, John C. Cheville, Christine M. Lohse, et al. Grading Chromophobe Renal Cell Carcinoma: Evidence for a Four-tiered Classification Incorporating Coagulative Tumor Necrosis. Eur Urol 2021;79:225-31: Two-, Three-, or Four-tiered Grading of Chromophobe Renal Cancer: That's the Question! European Urology, 80(1), e17-e18. https://doi.org/10.1016/j.eururo.2021.03.025
Ortiz-Brüchle, N., Wucherpfennig, S., Rose, M., Garczyk, S., Bertz, S., Hartmann, A.,... Gaisa, N.T. (2021). Molecular characterization of muellerian tumors of the urinary tract. Genes, 12(6). https://doi.org/10.3390/genes12060880
Ott, O., Gani, C., Lindner, L.H., Schmidt, M., Lamprecht, U., Abdel-Rahman, S.,... Fietkau, R. (2021). Neoadjuvant chemoradiation combined with regional hyperthermia in locally advanced or recurrent rectal cancer. Cancers, 13(6), 1-13. https://doi.org/10.3390/cancers13061279
Peuser, M., Hartmann, A., Schmidt, D., Mackensen, A., & Meidenbauer, N. (2021). Beta-HCG elevation as first sign of a malignant somatic transformation of a non-seminomatous germ cell tumor. In ONCOLOGY RESEARCH AND TREATMENT (pp. 266-266). BASEL: KARGER.
Polifka, I., Agaimy, A., Moch, H., & Hartmann, A. (2021). Histologische Subtypen des Nierenzellkarzinoms: Übersicht und neue Entwicklungen. Pathologe. https://doi.org/10.1007/s00292-021-00937-6
Pour Farid, P., Eckstein, M., Merkel, S., Grützmann, R., Hartmann, A., Bruns, V.,... Geppert, C.-I. (2021). Novel criteria for intratumoral budding with prognostic relevance for colon cancer and its histological subtypes. International Journal of Molecular Sciences, 22(23). https://doi.org/10.3390/ijms222313108
Rooper, L.M., Agaimy, A., Dickson, B.C., Dueber, J.C., Eberhart, C.G., Gagan, J.,... Bishop, J.A. (2021). DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base Detailed Clinicopathologic Characterization of a Distinctive Entity. American Journal of Surgical Pathology, 45(12), 1682-1693. https://doi.org/10.1097/PAS.0000000000001741
Rueschoff, J., Baretton, G., Blaeker, H., Dietmaier, W., Dietel, M., Hartmann, A.,... Buettner, R. (2021). MSI testing What's new? What should be considered? Pathologe. https://doi.org/10.1007/s00292-021-00948-3
Rüschoff, J., Baretton, G., Bläker, H., Dietmaier, W., Dietel, M., Hartmann, A.,... Büttner, R. (2021). MSI testing: What is new? What should be considered? German version MSI-Testung: Was ist neu? Was ist zu beachten? Pathologe. https://doi.org/10.1007/s00292-021-00944-7
Schmitz-Draeger, B.J., Skutetzki, A., Rieker, R.J., Schwab, S.A., Stöhr, R., Bismarck, E.,... Hartmann, A. (2021). Eosinophilic cystitis mimicking bladder cancer—considerations on the management based upon a case report and a review of the literature. Virchows Archiv. https://doi.org/10.1007/s00428-021-03049-x
Schnellhardt, S., Segelhorst, S., Erber, R., Daniel, C., Hartmann, A., Fasching, P.,... Rübner, M. (2021). Shifts in Macrophage as a prognostic Biomarker in Patients with luminal Breast Cancer - A Confirmatory Study. In STRAHLENTHERAPIE UND ONKOLOGIE (pp. S52-S53). HEIDELBERG: SPRINGER HEIDELBERG.
Schubart, C., Stöhr, R., Tögel, L., Fuchs, F., Sirbu, H., Seitz, G.,... Vieth, M. (2021). Met amplification in non‐small cell lung cancer (Nsclc)— a consecutive evaluation using next‐generation sequencing (ngs) in a real‐world setting. Cancers, 13(19). https://doi.org/10.3390/cancers13195023
Semrau, S., Gostian, A.O., Traxdorf, M., Eckstein, M., Rutzner, S., von der Grün, J.,... Hecht, M. (2021). Implementation of double immune checkpoint blockade increases response rate to induction chemotherapy in head and neck cancer. Cancers, 13(8). https://doi.org/10.3390/cancers13081959
Sikic, D., Eckstein, M., Weyerer, V., Kubon, J., Breyer, J., Roghmann, F.,... Wach, S. (2021). High expression of ERBB2 is an independent risk factor for reduced recurrence-free survival in patients with stage T1 non-muscle-invasive bladder cancer. Urologic Oncology-Seminars and Original Investigations. https://doi.org/10.1016/j.urolonc.2021.06.021
Sikic, D., Taubert, H., Breyer, J., Eckstein, M., Weyerer, V., Keck, B.,... Wach, S. (2021). The Prognostic Value of FGFR3 Expression in Patients with T1 Non-Muscle Invasive Bladder Cancer. Cancer Management and Research , 13, 6567-6578. https://doi.org/10.2147/CMAR.S318893
Sikic, D., Taubert, H., Wirtz, R.M., Breyer, J., Eckstein, M., Weyerer, V.,... Keck, B. (2021). High androgen receptor mrna expression is associated with improved outcome in patients with high-risk non-muscle-invasive bladder cancer. Life, 11(7). https://doi.org/10.3390/life11070642
Sikic, D., Weyerer, V., Geppert, C.-I., Bertz, S., Lange, F., Taubert, H.,... Eckstein, M. (2021). Utility of stromal tumor infiltrating lymphocyte scoring (sTILs) for risk stratification of patients with muscle-invasive urothelial bladder cancer after radical cystectomy. Urologic Oncology-Seminars and Original Investigations. https://doi.org/10.1016/j.urolonc.2021.07.025
Spörl, S., Erber, R., Gerken, M., Fischer, R., Taxis, J., Meier, J.K.,... Spoerl, S. (2021). A20 as a novel prognostic factor for recurrence and patients' survival in oral squamous cell carcinoma. In ONCOLOGY RESEARCH AND TREATMENT (pp. 248-248). BASEL: KARGER.
Stehr, A., Wang, G., Demmler, R., Stemmler, M., Straube, J., Tripal, P.,... Stürzl, M. (2021). Neutrophil extracellular traps drive epithelial‐mesenchymal transition of human colon cancer. Journal of Pathology. https://doi.org/10.1002/path.5860
Stöhr, R., Wendler, O.D., Giedl, J., Richter, G., Campean, V., Burger, M.,... Wullich, B. (2021). Risk of penile tumor development in Caucasian individuals is independent of the coding variant rs7208422 in the TMC8 (EVER2) gene. Molecular and Clinical Oncology, 15(6). https://doi.org/10.3892/mco.2021.2429
Stübs, F., Gaß, P., Dietl, A., Schulmeyer, C., Adler, W., Geppert, C.-I.,... Koch, M. (2021). Human papilloma virus genotype distribution in women with premalignant or malignant lesions of the uterine cervix. Archives of Gynecology and Obstetrics. https://doi.org/10.1007/s00404-021-05986-z
Taubert, H., Eckstein, M., Epple, E., Jung, R., Weigelt, K., Lieb, V.,... Wach, S. (2021). Immune Cell-Associated Protein Expression Helps to Predict Survival in Muscle-Invasive Urothelial Bladder Cancer Patients after Radical Cystectomy and Optional Adjuvant Chemotherapy. Cells, 10(1). https://doi.org/10.3390/cells10010159
Tully, K.H., Jütte, H., Wirtz, R.M., Jarczyk, J., Santiago-Walker, A., Zengerling, F.,... Eckstein, M. (2021). Prognostic Role of FGFR Alterations and FGFR mRNA Expression in Metastatic Urothelial Cancer Undergoing Checkpoint Inhibitor Therapy. Urology. https://doi.org/10.1016/j.urology.2021.05.055
Villegas, S.L., Nekljudova, V., Pfarr, N., Engel, J., Untch, M., Schrodi, S.,... Loibl, S. (2021). Therapy response and prognosis of patients with early breast cancer with low positivity for hormone receptors – An analysis of 2765 patients from neoadjuvant clinical trials. European Journal of Cancer, 148, 159-170. https://doi.org/10.1016/j.ejca.2021.02.020
Vitali, F., Wein, A., Rath, T., Eckstein, M., Neufert, C., Siebler, J.,... Merkel, S. (2021). The outcome of patients with inflammatory bowel disease-associated colorectal cancer is not worse than that of patients with sporadic colorectal cancer-a matched-pair analysis of survival. International Journal of Colorectal Disease. https://doi.org/10.1007/s00384-021-04072-9
Wang, G., Amin, M.B., Grossmann, P., Ptakova, N., Hayes, M., Hartmann, A.,... Hes, O. (2021). Renal cell tumor with sex-cord/gonadoblastoma-like features: analysis of 6 cases. Virchows Archiv. https://doi.org/10.1007/s00428-021-03235-x
Wein, A., Stöhr, R., Kersting, S., Siebler, J., Merkel, S., Busse, D.,... Grützmann, R. (2021). A Possible Distinct Molecular Subtype (Quintuple-Wildtype) of Metastatic Colorectal Cancer in First-Line Anti-EGFR Therapy with Cetuximab Plus FOLFIRI - Palliative Precision Therapy and a Multidisciplinary Treatment Approach: Interim Analysis of the IVOPAK II Trial with Early Results. Oncology. https://doi.org/10.1159/000519252
Wetzl, M., Wenkel, E., Balbach, E., Dethlefsen, E., Hartmann, A., Emons, J.,... Ohlmeyer, S. (2021). Detection of microcalcifications in spiral breast computed tomography with photon-counting detector is feasible: A specimen study. Diagnostics, 11(5). https://doi.org/10.3390/diagnostics11050848
Weyerer, V., Eckstein, M., Strissel, P., Wullweber, A., Lange, F., Tögel, L.,... Giedl, J. (2021). Tert promoter mutation analysis of whole-organ mapping bladder cancers. Genes, 12(2), 1-10. https://doi.org/10.3390/genes12020230
Weyerer, V., Ortiz-Bruechle, N., Demes, M., Schildgen, O., Haybaeck, J., Westphal, G.,... Holtkamp, N. (2021). NTRK Testing Practice in German Pathologies. In MODERN PATHOLOGY (pp. 1075-1076). LONDON: SPRINGERNATURE.
Weyerer, V., Strissel, P., Stohr, C., Eckstein, M., Wach, S., Taubert, H.,... Strick, R. (2021). Endogenous Retroviral-K Envelope Is a Novel Tumor Antigen and Prognostic Indicator of Renal Cell Carcinoma. Frontiers in Oncology, 11. https://doi.org/10.3389/fonc.2021.657187
Weyerer, V., Strissel, P., Strick, R., Sikic, D., Geppert, C.-I., Bertz, S.,... Eckstein, M. (2021). Integration of spatial pd-l1 expression with the tumor immune microenvironment outperforms standard pd-l1 scoring in outcome prediction of urothelial cancer patients. Cancers, 13(10). https://doi.org/10.3390/cancers13102327
Weyerer, V., Stöhr, R., Bertz, S., Lange, F., Geppert, C.-I., Wach, S.,... Eckstein, M. (2021). Prognostic impact of molecular muscle-invasive bladder cancer subtyping approaches and correlations with variant histology in a population-based mono-institutional cystectomy cohort. World Journal of Urology. https://doi.org/10.1007/s00345-021-03788-1
Wohlschlaeger, J., Greimelmaier, K., Ramankulov, A., Feist, H., Loch, T., Hager, T.,... Agaimy, A. (2021). Nodular tumour of the Vas deferens with epithelial structures. Pathologe. https://doi.org/10.1007/s00292-021-00992-z
Wullweber, A., Strick, R., Lange, F., Sikic, D., Taubert, H., Wach, S.,... Eckstein, M. (2021). Bladder tumor subtype commitment occurs in carcinoma in-situ driven by key signaling pathways including ECM remodeling. In EUROPEAN UROLOGY (pp. S640-S640). AMSTERDAM: ELSEVIER.
Wullweber, A., Strick, R., Lange, F., Sikic, D., Taubert, H., Wach, S.,... Eckstein, M. (2021). Bladder Tumor Subtype Commitment Occurs in Carcinoma In Situ Driven by Key Signaling Pathways Including ECM Remodeling. Cancer Research, 81(6), 1552-1566. https://doi.org/10.1158/0008-5472.CAN-20-2336
van der Kwast, T.H., Liedberg, F., Black, P.C., Kamat, A., van Rhijn, B.W.G., Algaba, F.,... Cheng, L. (2021). International Society of Urological Pathology Expert Opinion on Grading of Urothelial Carcinoma. European Urology Focus. https://doi.org/10.1016/j.euf.2021.03.017

2020

Achenbach, F., Rose, M., Ortiz-Brüchle, N., Seillier, L., Knüchel, R., Weyerer, V.,... Gaisa, N.T. (2020). Swi/snf alterations in squamous bladder cancers. Genes, 11(11), 1-15. https://doi.org/10.3390/genes11111368
Agaimy, A., Bonert, M., Naqvi, A., Wang, C., Hes, O., Trpkov, K.,... Hartmann, A. (2020). Langerhans Cell Histiocytosis Occurring in a Renal Cell Carcinoma is a Neoplastic Process: Clinicopathologic and Molecular Study of Five Cases. In LABORATORY INVESTIGATION (pp. 843-844). Los Angeles, CA, US: NEW YORK: NATURE PUBLISHING GROUP.
Agaimy, A., Bonert, M., Naqvi, A., Wang, C., Trpkov, K., Dettmar, P.,... Hartmann, A. (2020). Langerhans Cell Histiocytosis Associated with Renal Cell Carcinoma Is a Neoplastic Process: Clinicopathologic and Molecular Study of 7 Cases. American Journal of Surgical Pathology, 44(12), 1658-1665. https://doi.org/10.1097/PAS.0000000000001562
Agaimy, A., Daum, O., Michal, M., Hartmann, A., & Lauwers, G. (2020). Polypoid Undifferentiated Rhabdoid Carcinoma in the Intestine: A Distinctive Presentation of Metastatic -Mostly Occult -Undifferentiated Non-small Cell Lung Carcinoma Illustrated in a Series of 12 Cases. In MODERN PATHOLOGY (pp. 609-609). Los Angeles, CA, US: NEW YORK: NATURE PUBLISHING GROUP.
Agaimy, A., Stöhr, R., Tögel, L., Hartmann, A., & Cramer, T. (2020). YAP1-MAML2-Rearranged Poroid Squamous Cell Carcinoma (Squamoid Porocarcinoma) Presenting as a Primary Parotid Gland Tumor. Head and Neck Pathology. https://doi.org/10.1007/s12105-020-01181-9
Agaimy, A., Witkowski, L., Stöhr, R., Cuenca, J.C.C., González-Muller, C.A., Brütting, A.,... Eloy, C. (2020). Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations—is the term “thyroblastoma” more appropriate? Virchows Archiv. https://doi.org/10.1007/s00428-020-02853-1
Ahrens, M., Escudier, B., Boleti, E., Grimm, M.-O., Goupir, M.G., Barthelemy, P.,... Bergmann, L. (2020). A Randomized Phase II Study of Nivolumab Plus Ipilimumab Versus Standard of Care in Previously Untreated and Advanced Non-Clear Cell Renal Cell Carcinoma (Suniforecast). In ONCOLOGY RESEARCH AND TREATMENT (pp. 226-226). BASEL: KARGER.
Ahrens, M., Hartmann, A., & Bergmann, L. (2020). What is new in the diagnosis and therapy of renal cell carcinoma? Was ist neu bei der Diagnostik und Therapie des Nierenzellkarzinoms? Deutsche Medizinische Wochenschrift, 145(11), 734-739. https://doi.org/10.1055/a-0982-4331
Alfer, J., Fattahi, A., Bleisinger, N., Krieg, J., Behrens, R., Dittrich, R.,... Popovici, R.M. (2020). Endometrial Dating Method Detects Individual Maturation Sequences During the Secretory Phase. In Vivo, 34(4), 1951-1963. https://doi.org/10.21873/invivo.11992
Baier, J., Gänsbauer, M., Giessler, C., Arnold, H., Muske, M., Schleicher, U.,... Mattner, J. (2020). Arginase expression impedes the resolution of intestinal inflammation by altering the fecal microbiome and the metabolome. Journal of Clinical Investigation. https://doi.org/10.1172/JCI126923
Bergmann, L., Grünwald, V., Maute, L., Grimm, M.O., Weikert, S., Schleicher, J.,... Gauler, T. (2020). A Randomized Phase IIa Trial with Temsirolimus versus Sunitinib in Advanced Non-Clear Cell Renal Cell Carcinoma: An Intergroup Study of the CESAR Central European Society for Anticancer Drug Research-EWIV and the Interdisciplinary Working Group on Renal Cell Cancer (IAGN) of the German Cancer Society. Oncology Research and Treatment. https://doi.org/10.1159/000508450
Bertz, S., Enßer, A., Stöhr, R., Eckstein, M., Apel, H., Mayr, D.,... Knöll, A. (2020). Variant morphology and random chromosomal integration of BK polyomavirus in posttransplant urothelial carcinomas. Modern Pathology. https://doi.org/10.1038/s41379-020-0489-0
Bertz, S., Stöhr, R., Gaisa, N.T., Wullich, B., Hartmann, A., & Agaimy, A. (2020). TERT promoter mutation analysis as a surrogate to morphology and immunohistochemistry in problematic spindle cell lesions of the urinary bladder. Histopathology. https://doi.org/10.1111/his.14206
Boor, P., & Hartmann, A. (2020). Bericht zur Late-Breaking Session Pathologie und COVID-19. Pathologe. https://doi.org/10.1007/s00292-020-00882-w
Breyer, J., Monga, M., Mayr, R., Otto, W., Burger, M., Eckstein, M.,... Santiago-Walker, A. (2020). Assessment of prognostic and predictive value of FGFR alterations (FGFRa) in a real-world cohort of patients (pts) with high-risk pT1 non-muscle-invasive bladder cancer (NMIBC). In ANNALS OF ONCOLOGY (pp. S587-S588). AMSTERDAM: ELSEVIER.
Dietrich, P., Wormser, L., Fritz, V., Seitz, T., de Maria, M., Schambony, A.,... Hellerbrand, C. (2020). Molecular cross-talk between Y5-receptor and neuropeptide Y drives liver cancer. Journal of Clinical Investigation, 130(5), 2509-2526. https://doi.org/10.1172/JCI131919
Eckstein, M., Epple, E., Jung, R., Weigelt, K., Lieb, V., Sikic, D.,... Wach, S. (2020). CCL2 expression in tumor cells and tumor-infiltrating immune cells shows divergent prognostic potential for bladder cancer patients depending on lymph node stage. Cancers, 12(5). https://doi.org/10.3390/cancers12051253
Eckstein, M., Strissel, P., Strick, R., Weyerer, V., Wirtz, R., Pfannstiel, C.,... Sikic, D. (2020). Cytotoxic T-cell-related gene expression signature predicts improved survival in muscle-invasive urothelial bladder cancer patients after radical cystectomy and adjuvant chemotherapy. Journal for ImmunoTherapy of Cancer, 8(1). https://doi.org/10.1136/jitc-2019-000162
Eckstein, M., Strissel, P., Strick, R., Weyerer, V., Wirtz, R.M., Pfannstiel, C.,... Sikic, D. (2020). Immune Cell Gene Expression Signature is Associated with Improved Outcome in Muscle-Invasive Urothelial Bladder Cancer Patients Treated with Radical Cystectomy. In ONCOLOGY RESEARCH AND TREATMENT (pp. 70-70). BASEL: KARGER.
Ellmann, S., Schlicht, M., Dietzel, M., Janka, R.M., Hammon, M., Saake, M.,... Bäuerle, T. (2020). Computer-aided diagnosis in multiparametric mri of the prostate: An open-access online tool for lesion classification with high accuracy. Cancers, 12(9), 1-15. https://doi.org/10.3390/cancers12092366
Emons, J., Fasching, P., Wunderle, M., Heindl, F., Rieger, J., Horn, F.,... Jud, S. (2020). Assessment of the additional clinical potential of X-ray dark-field imaging for breast cancer in a preclinical setup. Therapeutic Advances in Medical Oncology, 12. https://doi.org/10.1177/1758835920957932
Emons, J., Fasching, P., Wunderle, M., Heindl, F., Rieger, J., Horn, F.,... Jud, S.M. (2020). Assessment of the additional clinical potential of X-ray dark-field imaging for breast cancer in a preclinical setup. In GEBURTSHILFE UND FRAUENHEILKUNDE (pp. E111-E111). STUTTGART: GEORG THIEME VERLAG KG.
Erber, R., Haller, F., Hartmann, A., & Agaimy, A. (2020). Prominent entrapment of respiratory epithelium in primary and metastatic intrapulmonary non-epithelial neoplasms: a frequent morphological pattern closely mimicking adenofibroma and other biphasic pulmonary lesions. Virchows Archiv. https://doi.org/10.1007/s00428-020-02796-7
Erber, R., & Hartmann, A. (2020). Histology of Luminal Breast Cancer. Breast Care. https://doi.org/10.1159/000509025
Erber, R., & Hartmann, A. (2020). Understanding PD-L1 Testing in Breast Cancer: A Practical Approach. Breast Care. https://doi.org/10.1159/000510812
Erber, R., Hartmann, A., Fasching, P., Stöhr, R., Beckmann, M., Zentgraf, M.,... Ferrazzi, F. (2020). Europe-side external quality assessment (EQA) of RNA based testing of ER, PR, HER2 and Ki67 in invasive breast cancer. In ANNALS OF ONCOLOGY (pp. S25-S25). ONLINE: AMSTERDAM: ELSEVIER.
Erber, R., Meyer, J., Taubert, H., Fasching, P., Wach, S., Häberle, L.,... Rübner, M. (2020). Piwi-like 1 and piwi-like 2 expression in breast cancer. Cancers, 12(10), 1-17. https://doi.org/10.3390/cancers12102742
Erber, R., Rübner, M., Davenport, S., Hauke, S., Beckmann, M., Hartmann, A.,... Fasching, P. (2020). Impact of fibroblast growth factor receptor 1 (FGFR1) amplification on the prognosis of breast cancer patients. Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-020-05865-2
Erber, R., Stoehr, R., Haller, F., Haderlein, M., Hartmann, A., & Agaimy, A. (2020). Comparison of Intrinsic PAM50 Gene Expression Analysis and Immunohistochemical Subtypes of Salivary Duct Carcinoma. In LABORATORY INVESTIGATION (pp. 1193-1193). Los Angeles, CA, US: NEW YORK: NATURE PUBLISHING GROUP.
Erber, R., Warth, A., Muley, T., Hartmann, A., Herpel, E., & Agaimy, A. (2020). BAP1 Loss is a Useful Adjunct to Distinguish Malignant Mesothelioma Including the Adenomatoid-like Variant From Benign Adenomatoid Tumors. Applied Immunohistochemistry & Molecular Morphology, 28(1), 67-73. https://doi.org/10.1097/PAI.0000000000000700
Erlmeier, F., Steffens, S., Stöhr, C., Herrmann, E., Polifka, I., Agaimy, A.,... Ivanyi, P. (2020). Characterization of PD-1 and PD-L1 Expression in Papillary Renal Cell Carcinoma: Results of a Large Multicenter Study. Clinical Genitourinary Cancer. https://doi.org/10.1016/j.clgc.2020.07.002
Friedrich, M., Heimer, N., Stoehr, C., Steven, A., Wach, S., Taubert, H.,... Seliger, B. (2020). CREB1 is affected by the microRNAs miR-22-3p, miR-26a-5p, miR-27a-3p, and miR-221-3p and correlates with adverse clinicopathological features in renal cell carcinoma. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-63403-y
Friedrich, M., Stoehr, C., Jasinski-Bergner, S., Hartmann, A., Wach, S., Wullich, B.,... Seliger, B. (2020). Characterization of the expression and immunological impact of the transcriptional activator CREB in renal cell carcinoma. Journal of Translational Medicine, 18(1). https://doi.org/10.1186/s12967-020-02544-0
Gakis, G., Karl, A., Bertz, S., Burger, M., Fritsche, H.M., Hartmann, A.,... Stenzl, A. (2020). Transurethral en bloc submucosal hydrodissection vs conventional resection for resection of non-muscle-invasive bladder cancer (HYBRIDBLUE): a randomised, multicentre trial. Bju International. https://doi.org/10.1111/bju.15150
Galon, J., Kawakami, Y., Torigoe, T., Wang, Y., Patel, P.S., Vora, H.,... Pages, F. (2020). Clinical performance of Immunoscore (R) in early colon cancer in the Asian population. In ANNALS OF ONCOLOGY (pp. S1273-S1273). AMSTERDAM: ELSEVIER.
Gaß, P., Haberle, L., Hein, A., Jud, S., Lux, M.P., Hack, C.,... Wunderle, M. (2020). Influence of the Family Anamnesis of Breast or Ovarian Cancer on the pathological Complete Remission and the Prognosis in Patients with Breast Cancer after neoadjuvant Chemotherapy. In GEBURTSHILFE UND FRAUENHEILKUNDE (pp. E111-E112). STUTTGART: GEORG THIEME VERLAG KG.
Haller, F., Moskalev, E., Kuck, S., Bieg, M., Winkelmann, C., Müller, S.,... Agaimy, A. (2020). Nuclear NR4A2 (Nurr1) Immunostaining is a Novel Marker for Acinic Cell Carcinoma of the Salivary Glands Lacking the Classic NR4A3 (NOR-1) Upregulation. American Journal of Surgical Pathology. https://doi.org/10.1097/PAS.0000000000001494
Hassler, M.R., Bray, F., Catto, J.W., Grollman, A.P., Hartmann, A., Margulis, V.,... Faltas, B.M. (2020). Molecular Characterization of Upper Tract Urothelial Carcinoma in the Era of Next-generation Sequencing: A Systematic Review of the Current Literature. European Urology. https://doi.org/10.1016/j.eururo.2020.05.039
Hecht, M., Gostian, A.O., Eckstein, M., Rutzner, S., von der Grün, J., Illmer, T.,... Fietkau, R. (2020). Safety and efficacy of single cycle induction treatment with cisplatin/docetaxel/ durvalumab/tremelimumab in locally advanced HNSCC: first results of CheckRad-CD8. Journal for ImmunoTherapy of Cancer, 8(2). https://doi.org/10.1136/jitc-2020-001378
Heindl, F., Fasching, P., Hein, A., Hack, C., Heusinger, K., Gaß, P.,... Jud, S. (2020). Mammographic Density and Prognosis in Patients with primary Breast Cancer - Loss of Risk with increasing Age. In GEBURTSHILFE UND FRAUENHEILKUNDE (pp. E112-E113). STUTTGART: GEORG THIEME VERLAG KG.
Hülsen, S., Lippolis, E., Ferrazzi, F., Otto, W., Distel, L., Fietkau, R.,... Geppert, C.-I. (2020). High stroma T-cell infiltration is associated with better survival in stage pT1 bladder cancer. International Journal of Molecular Sciences, 21(21), 1-13. https://doi.org/10.3390/ijms21218407
Jung, S., Ballheimer, Y.E., Brackmann, F., Zoglauer, D., Geppert, C.-I., Hartmann, A., & Trollmann, R. (2020). Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain. Brain Research, 1735. https://doi.org/10.1016/j.brainres.2020.146760
Kamoun, A., de Reyniès, A., Allory, Y., Sjödahl, G., Robertson, A.G., Seiler, R.,... Weinstein, J.N. (2020). Reply To Kenneth B. Yatai, Mark J. Dunning, Dennis Wang. Consensus Genomic Subtypes of Muscle-invasive Bladder Cancer: A Step in the Right Direction but Still a Long Way To Go. Eur Urol. In press. European Urology. https://doi.org/10.1016/j.eururo.2019.12.014
Karl, A., Buchner, A., Tympner, C., Kirchner, T., Ganswindt, U., Belka, C.,... Haese, A. (2020). Correction to: The natural course of pT2 prostate cancer with positive surgical margin: predicting biochemical recurrence (World Journal of Urology, (2015), 33, 7, (973-979), 10.1007/s00345-015-1510-y). World Journal of Urology. https://doi.org/10.1007/s00345-020-03136-9
Kim, W.Y., Rose, T., Roghmann, F., Eckstein, M., Jarczyk, J., Zengerling, F.,... Wirtz, R. (2020). Predictive value of fibroblast growth factor receptor (FGFR) alterations on anti-PD-(L)1 treatment outcomes in patients (Pts) with advanced urothelial cancer (UC): Pooled analysis of real-world data. In JOURNAL OF CLINICAL ONCOLOGY. San Francisco, CA, US: ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY.
Klenske, E., Hartmann, A., Atreya, R., Neurath, M., & Rath, T. (2020). Perforations after routine biopsy in IBD patients, their management and potential risk reductions by microscopic imaging with endocytoscopy. Journal of Gastrointestinal and Liver Diseases, 29(3), 465-466. https://doi.org/10.15403/jgld-2267
Klingler, A., Regensburger, D., Tenkerian, C., Britzen-Laurent, N., Hartmann, A., Stürzl, M., & Naschberger, E. (2020). Species-, organ- and cell-type-dependent expression of SPARCL1 in human and mouse tissues. PLoS ONE, 15(5), e0233422. https://doi.org/10.1371/journal.pone.0233422
Kriegsmann, M., Casadonte, R., Maurer, N., Stoehr, C., Erlmeier, F., Moch, H.,... Kriegsmann, K. (2020). Mass Spectrometry Imaging Differentiates Chromophobe Renal Cell Carcinoma and Renal Oncocytoma with High Accuracy. Journal of Cancer, 11(20), 6081-6089. https://doi.org/10.7150/jca.47698
Kubon, J., Sikic, D., Eckstein, M., Weyerer, V., Stöhr, R., Neumann, A.,... Wach, S. (2020). Analysis of CXCL9, PD1 and PD-L1 mRNA in stage T1 non-muscle invasive bladder cancer and their association with prognosis. Cancers, 12(10), 1-13. https://doi.org/10.3390/cancers12102794
König, P., Eckstein, M., Jung, R., Abdulrahman, A., Guzman, J., Weigelt, K.,... Lieb, V. (2020). Expression of AR-V7 (Androgen receptor variant 7) protein in granular cytoplasmic structures is an independent prognostic factor in prostate cancer patients. Cancers, 12(9), 1-15. https://doi.org/10.3390/cancers12092639
Lang-Schwarz, C., Agaimy, A., Atreya, R., Becker, C., Danese, S., Flejou, J.-F.,... Vieth, M. (2020). Maximizing the diagnostic information from biopsies in chronic inflammatory bowel diseases: recommendations from the Erlangen International Consensus Conference on Inflammatory Bowel Diseases and presentation of the IBD-DCA score as a proposal for a new index for histologic activity assessment in ulcerative colitis and Crohn's disease. Virchows Archiv. https://doi.org/10.1007/s00428-020-02982-7
Lasota, J., Chlopek, M., Wasag, B., Kowalik, A., Christiansen, J., Lamoureux, J.,... Miettinen, M. (2020). Colorectal Adenocarcinomas Harboring ALK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 12 Cases and Review of the Literature. American Journal of Surgical Pathology, 44(9), 1224-1234. https://doi.org/10.1097/PAS.0000000000001512
Lasota, J., Chłopek, M., Lamoureux, J., Christiansen, J., Kowalik, A., Wasąg, B.,... Miettinen, M. (2020). Colonic Adenocarcinomas Harboring NTRK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 16 Cases and Review of the Literature. American Journal of Surgical Pathology, 44(2), 162-173. https://doi.org/10.1097/PAS.0000000000001377
Lauer, V., Grampp, S., Platt, J., Lafleur, V., Lombardi, O., Choudhry, H.,... Schödel, J. (2020). Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI. Journal of Biological Chemistry, 295(13), 4065-4078. https://doi.org/10.1074/jbc.RA119.009827
Leppkes, M., Knopf, J., Naschberger, E., Lindemann, A., Singh, J., Herrmann, I.,... Schauer, C. (2020). Vascular occlusion by neutrophil extracellular traps in COVID-19. EBioMedicine, 58. https://doi.org/10.1016/j.ebiom.2020.102925
Lindner, P., Paul, S., Eckstein, M., Hampel, C., Muenzner, J.K., Erlenbach-Wuensch, K.,... Schneider-Stock, R. (2020). EMT transcription factor ZEB1 alters the epigenetic landscape of colorectal cancer cells. Cell Death & Disease, 11(2). https://doi.org/10.1038/s41419-020-2340-4
Maisch, S., Müller, S.K., Traxdorf, M., Weyerer, V., Stoehr, R., Iro, H.,... Agaimy, A. (2020). Sinonasal papillomas: A single centre experience on 137 cases with emphasis on malignant transformation and EGFR/KRAS status in “carcinoma ex papilloma”. Annals of Diagnostic Pathology, 46. https://doi.org/10.1016/j.anndiagpath.2020.151504
Martins, F.C., Couturier, D.L., Paterson, A., Karnezis, A.N., Chow, C., Nazeran, T.M.,... Brenton, J.D. (2020). Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium. British Journal of Cancer. https://doi.org/10.1038/s41416-020-0900-0
Meintker, L., Haller, F., Tögel, L., Schmidt, D., Waibel, H., Hartmann, A.,... Meidenbauer, N. (2020). Successful Targeting of BRAF V600E Mutation With Vemurafenib in a Treatment-Resistant Extragonadal Nonseminomatous Germ-Cell Tumor. JCO Precision Oncology, 233-238. https://doi.org/10.1200/PO.19.00377
Mlecnik, B., Bifulco, C., Bindea, G., Marliot, F., Lugli, A., Lee, J.J.,... Galon, J. (2020). Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer. Journal of Clinical Oncology, 38(31), 3638-+. https://doi.org/10.1200/JCO.19.03205
Mlecnik, B., Bifulco, C., Marliot, F., Lugli, A., Nagtegaal, I., Hartmann, A.,... Galon, J. (2020). A TNM-Immune (TNM-I) classification staging system for predicting survival in colon cancer in a multicenter international SITC study. In ANNALS OF ONCOLOGY (pp. S238-S238). ONLINE: AMSTERDAM: ELSEVIER.
Ohashi, R., Martignoni, G., Hartmann, A., Caliò, A., Segala, D., Stöhr, C.,... Moch, H. (2020). Correction to: Multi-institutional re-evaluation of prognostic factors in chromophobe renal cell carcinoma: proposal of a novel two-tiered grading scheme (Virchows Archiv, (2019), 10.1007/s00428-019-02710-w). Virchows Archiv. https://doi.org/10.1007/s00428-020-02786-9
Peter, S.C., Wenkel, E., Weiland, E., Dietzel, M., Janka, R.M., Hartmann, A.,... Ellmann, S. (2020). Combination of an ultrafast TWIST-VIBE Dixon sequence protocol and diffusion-weighted imaging into an accurate easily applicable classification tool for masses in breast MRI. European Radiology. https://doi.org/10.1007/s00330-019-06608-8
Popp, B., Erber, R., Kraus, C., Vasileiou, G., Hoyer, J., Burghaus, S.,... Agaimy, A. (2020). Targeted sequencing of FH-deficient uterine leiomyomas reveals biallelic inactivating somatic fumarase variants and allows characterization of missense variants. Modern Pathology. https://doi.org/10.1038/s41379-020-0596-y
Rauch, T., Rieger, J., Pelzer, G., Horn, F., Erber, R., Wunderle, M.,... Anton, G. (2020). Discrimination analysis of breast calcifications using x-ray dark-field radiography. Medical Physics. https://doi.org/10.1002/mp.14043
Reike, M., Juette, H., Wirtz, R., Erben, P., Tully, K., Eckstein, M.,... Roghmann, F. (2020). Smoking status and PD-L1 mRNA-expression as a predictor of response to neoadjuvant chemotherapy in patients diagnosed with muscle invasive bladder cancer. In JOURNAL OF CLINICAL ONCOLOGY. San Francisco, CA, US: ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY.
Rinaldetti, S., Worst, T.S., Rempel, E., Kriegmair, M.C., Hartmann, A., Porubsky, S.,... Erben, P. (2020). Subtype specific expression and survival prediction of pivotal lncRNAs in muscle invasive bladder cancer. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-77252-2
Roesch, J., Haller, F., Lettmaier, S., Haderlein, M., Hartmann, A., Moskalev, E.,... Hecht, M. (2020). Use of NGS Gene Panel Analyzes for molecularly targeted System Therapy. In STRAHLENTHERAPIE UND ONKOLOGIE (pp. S198-S198). Weisbaden, DE: HEIDELBERG: SPRINGER HEIDELBERG.
Roghmann, F., Reike, M., Wirtz, R., Kriegmair, M., Erben, P., Tully, K.,... Juette, H. (2020). Association of KRT20 and KRT5 with response to neoadjuvant chemotherapy in patients diagnosed with muscle invasive bladder cancer. In JOURNAL OF CLINICAL ONCOLOGY. San Francisco, CA, US: ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY.
Rudolf, J., Büttner-Herold, M., Erlenbach-Wuensch, K., Posselt, R., Jeßberger, J., Haderlein, M.,... Distel, L. (2020). Regulatory T cells and cytotoxic T cells close to the epithelial–stromal interface are associated with a favorable prognosis. OncoImmunology, 9(1). https://doi.org/10.1080/2162402X.2020.1746149
Samaratunga, H., Delahunt, B., Egevad, L., Srigley, J.R., Billis, A., Bostwick, D.G.,... Varma, M. (2020). Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded. Pathology, 52(2), 192-196. https://doi.org/10.1016/j.pathol.2019.11.001
Schmiester, M., Dolnik, A., Kornak, U., Pfitzner, B., Hummel, M., Treue, D.,... Floercken, A. (2020). TFE3 activation in a TSC1-altered malignant PEComa: challenging the dichotomy of the underlying pathogenic mechanisms. Journal of Pathology: Clinical Research. https://doi.org/10.1002/cjp2.187
Schmitt, H., Ulmschneider, J., Billmeier, U., Scarozza, P., Sonnewald, S., Reid, S.,... Vieth, M. (2020). The TLR9 agonist cobitolimod induces IL10 producing wound healing macrophages and regulatory T cells in ulcerative colitis. Journal of Crohns & Colitis, 14(4), 508-524. https://doi.org/10.1093/ecco-jcc/jjz170
Schnellhardt, S., Erber, R., Büttner-Herold, M., Rosahl, M.-C., Ott, O., Strnad, V.,... Distel, L. (2020). Accelerated Partial Breast Irradiation: Identification of High Risk Tumors in Early Hormone Receptor-positive Breast Cancer by Macrophage Shift Classification. In STRAHLENTHERAPIE UND ONKOLOGIE (pp. S162-S162). Weisbaden, DE: HEIDELBERG: SPRINGER HEIDELBERG.
Schnellhardt, S., Erber, R., Büttner-Herold, M., Rosahl, M.C., Ott, O., Strnad, V.,... Distel, L. (2020). Accelerated partial breast irradiation: Macrophage polarisation shift classification identifies high-risk tumours in early hormone receptor-positive breast cancer. Cancers, 12(2). https://doi.org/10.3390/cancers12020446
Schnellhardt, S., Erber, R., Büttner-Herold, M., Rosahl, M.C., Ott, O., Strnad, V.,... Distel, L. (2020). Tumour-infiltrating inflammatory cells in early breast cancer: An underrated prognostic and predictive factor? International Journal of Molecular Sciences, 21(21), 1-17. https://doi.org/10.3390/ijms21218238
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Sikic, D., Eckstein, M., Wirtz, R.M., Jarczyk, J., Worst, T.S., Porubsky, S.,... Erben, P. (2020). FOXA1 Gene Expression for Defining Molecular Subtypes of Muscle-Invasive Bladder Cancer after Radical Cystectomy. Journal of Clinical Medicine, 9(4). https://doi.org/10.3390/jcm9040994
Simon, A.G., Tolkach, Y., Esser, L.K., Ellinger, J., Stoehr, C., Ritter, M.,... Toma, M.I. (2020). Mitophagy-associated genes PINK1 and PARK2 are independent prognostic markers of survival in papillary renal cell carcinoma and associated with aggressive tumor behavior. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-75258-4
Sommer, U., Baretton, G., Hartmann, A., Eckstein, M., Schwamborn, K., Weichert, W.,... Joehrens, K. (2020). Results of the first prototypical Ring Trial of QuIP for PD-L1 Expression in Urothelial Carcinomas. Pathologe, 41(4), 426-427.
Sommer, U., Eckstein, M., Ammann, J., Braunschweig, T., Macher-Göppinger, S., Schwamborn, K.,... Hartmann, A. (2020). Multicentric Analytical and Inter-observer Comparability of Four Clinically Developed Programmed Death-ligand 1 Immunohistochemistry Assays in Advanced Clear-cell Renal Cell Carcinoma. Clinical Genitourinary Cancer. https://doi.org/10.1016/j.clgc.2020.02.009
Steger, C.M., Hartmann, A., & Rieker, R. (2020). Molecular differences between arterial and venous grafts in the first year after coronary artery bypass grafting. Histochemistry and Cell Biology. https://doi.org/10.1007/s00418-020-01896-4
Stuebs, F.A., Adler, W., Beckmann, M., Gaß, P., Hartmann, A., Mehlhorn, G.,... Koch, M. (2020). Accuracy of colposcopic findings in detecting vaginal intraepithelial neoplasia: a retrospective study. In GEBURTSHILFE UND FRAUENHEILKUNDE (pp. E207-E207). STUTTGART: GEORG THIEME VERLAG KG.
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