We are working on the identification and validation of biomarker and target genes for pancreatic cancer. For this, we are handling the biobank of the surgical department and employing CRISPR/Cas9 and organoid technology.
Research projects
CRISPR/Cas9 in human pancreas organoids
Development of new markers
Identification of metastasis-associated genes
Recent publications
2024
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A.,... Perez-Mancera, P.A. (2024). Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis . Cancer Research , 84 (18), 2968-2984. https://doi.org/10.1158/0008-5472.CAN-23-3419
Mottini, C., Auciello, F.R., Manni, I., Pilarsky, C., Caputo, D., Caracciolo, G.,... Piaggio, G. (2024). The cross-talk between the macro and micro-environment in precursor lesions of pancreatic cancer leads to new and promising circulating biomarkers . Journal of Experimental & Clinical Cancer Research , 43 (1). https://doi.org/10.1186/s13046-024-03117-5
Podolska, M., Grützmann, R., Pilarsky, C., & Benard, A. (2024). IL-3: key orchestrator of inflammation . Frontiers in Immunology , 15 . https://doi.org/10.3389/fimmu.2024.1411047
Tang, Y., Tang, S., Yang, W., Zhang, Z., Wang, T., Wu, Y.,... Xue, J. (2024). MED12 loss activates endogenous retroelements to sensitise immunotherapy in pancreatic cancer . Gut . https://doi.org/10.1136/gutjnl-2024-332350
Zhang, S., Yun, D., Yang, H., Eckstein, M., Elbait, G.D., Zhou, Y.,... Pilarsky, C. (2024). Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer . Cell Death Discovery , 10 (1). https://doi.org/10.1038/s41420-024-01890-y
2023
Al-Fatlawi, A., Rusadze, E., Shmelkin, A., Malekian, N., Ozen, C., Pilarsky, C., & Schroeder, M. (2023). Netrank: network-based approach for biomarker discovery . BMC Bioinformatics , 24 (1). https://doi.org/10.1186/s12859-023-05418-6
Daunke, T., Beckinger, S., Rahn, S., Krüger, S., Heckl, S., Schäfer, H.,... Sebens, S. (2023). Expression and role of the immune checkpoint regulator PD-L1 in the tumor-stroma interplay of pancreatic ductal adenocarcinoma . Frontiers in Immunology , 14 . https://doi.org/10.3389/fimmu.2023.1157397
Dinter, J., Friedrich, R.P., Yang, H., Pilarsky, C., Mangge, H., Pöttler, M.,... Lyer, S. (2023). Mitoxantrone and Mitoxantrone-Loaded Iron Oxide Nanoparticles Induce Cell Death in Human Pancreatic Ductal Adenocarcinoma Cell Spheroids . Materials , 16 (7). https://doi.org/10.3390/ma16072906
Geyer, M., Schreyer, D., Gaul, L.M., Pfeffer, S., Pilarsky, C., & Queiroz, K. (2023). A microfluidic-based PDAC organoid system reveals the impact of hypoxia in response to treatment . Cell Death Discovery , 9 (1). https://doi.org/10.1038/s41420-023-01334-z
Han, Y., Drobisch, P., Krüger, A., William, D., Grützmann, K., Böthig, L.,... Kahlert, C. (2023). Plasma extracellular vesicle messenger RNA profiling identifies prognostic EV signature for non-invasive risk stratification for survival prediction of patients with pancreatic ductal adenocarcinoma . Journal of Hematology & Oncology , 16 (1). https://doi.org/10.1186/s13045-023-01404-w
He, H., Zhang, S., Yang, H., Xu, P., Kutschick, I., Pfeffer, S.,... Pilarsky, C. (2023). Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator . Cancers , 15 (1). https://doi.org/10.3390/cancers15010241
Krug, J., Rodrian, G., Petter, K., Yang, H., Khoziainova, S., Guo, W.,... Britzen-Laurent, N. (2023). N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy . Gastroenterology . https://doi.org/10.1053/j.gastro.2022.11.018
Zhang, J., Zhang, S., Dörflein, I., Ren, X., Pfeffer, S., Britzen-Laurent, N.,... Pilarsky, C. (2023). Impact of CRISPR/Cas9-Mediated CD73 Knockout in Pancreatic Cancer . Cancers , 15 (19). https://doi.org/10.3390/cancers15194842
2022
Chen, X.-Z., Guo, R., Zhao, C., Xu, J., Song, H., Yu, H.,... Zhang, J.-Y. (2022). A Novel Anti-Cancer Therapy: CRISPR/Cas9 Gene Editing . Frontiers in Pharmacology , 13 . https://doi.org/10.3389/fphar.2022.939090
De Andres, M.P., Jackson, R.J., Felipe, I., Zagorac, S., Pilarsky, C., Schlitter, A.M.,... Real, F.X. (2022). GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma . Gut . https://doi.org/10.1136/gutjnl-2021-325803
Fan, X.Y., Deng, Z.F., Yan, Y.Y., E Orel, V., Shypko, A., B Orel, V.,... Zhang, J.Y. (2022). Application of microfluidic chips in anticancer drug screening . Bosnian Journal of Basic Medical Sciences , 22 (3), 302-314. https://doi.org/10.17305/bjbms.2021.6484
Lan, B., Zeng, S., Zhang, S., Ren, X., Xing, Y., Kutschick, I.,... Pilarsky, C. (2022). CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer . Cancers , 14 (2). https://doi.org/10.3390/cancers14020326
Mahajan, U.M., Oehrle, B., Sirtl, S., Alnatsha, A., Goni, E., Regel, I.,... Mayerle, J. (2022). Independent Validation and Assay Standardization of Improved Metabolic Biomarker Signature to Differentiate Pancreatic Ductal Adenocarcinoma From Chronic Pancreatitis . Gastroenterology , 163 (5), 1407-1422. https://doi.org/10.1053/j.gastro.2022.07.047
Sankarasubramanian, S., Niethard, M., Pilarsky, C., Regenbrecht, C., & Wedeken, L. (2022). Meeting Medical Need - Development of a High-Throughput Assay Using Pancreatic Cancer Patient Derived Organoids as a Tool for Personalized Medicine . In ONCOLOGY RESEARCH AND TREATMENT (pp. 87-88). BASEL: KARGER.
Wu, Y., Wang, Y., Lu, Y., Luo, X., Huang, Y., Xie, T.,... Zhang, J. (2022). Microfluidic Technology for the Isolation and Analysis of Exosomes . Micromachines , 13 (10). https://doi.org/10.3390/mi13101571
Yang, H., Liu, B., Liu, D., Yang, Z., Zhang, S., Xu, P.,... Pilarsky, C. (2022). Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer . Cancers , 14 (13). https://doi.org/10.3390/cancers14133152
Yun, D., Yang, Z., Zhang, S., Yang, H., Liu, D., Grützmann, R.,... Britzen-Laurent, N. (2022). An m5C methylation regulator-associated signature predicts prognosis and therapy response in pancreatic cancer . Frontiers in Cell and Developmental Biology , 10 . https://doi.org/10.3389/fcell.2022.975684
Zeng, S., Lan, B., Ren, X., Zhang, S., Schreyer, D., Eckstein, M.,... Pilarsky, C. (2022). CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer . Journal of Experimental & Clinical Cancer Research , 41 (1). https://doi.org/10.1186/s13046-022-02443-w
2021
Adam, M.G., Beyer, G., Christiansen, N., Kamlage, B., Pilarsky, C., Distler, M.,... Lerch, M.M. (2021). Identification and validation of a multivariable prediction model based on blood plasma and serum metabolomics for the distinction of chronic pancreatitis subjects from non-pancreas disease control subjects . Gut , 70 (11), 2150-2158. https://doi.org/10.1136/gutjnl-2020-320723
Al-Fatlawi, A., Malekian, N., García, S., Henschel, A., Kim, I., Dahl, A.,... Schroeder, M. (2021). Deep learning improves pancreatic cancer diagnosis using rna-based variants . Cancers , 13 (11). https://doi.org/10.3390/cancers13112654
Dreyer, S.B., Upstill-Goddard, R., Paulus-Hock, V., Paris, C., Lampraki, E.M., Dray, E.,... Sansom, O.J. (2021). Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer . Gastroenterology , 160 (1), 362-377.e13. https://doi.org/10.1053/j.gastro.2020.09.043
Gollavilli, P.N., Parma, B., Siddiqui, A., Yang, H., Ramesh, V., Napoli, F.,... Ceppi, P. (2021). The role of miR-200b/c in balancing EMT and proliferation revealed by an activity reporter . Oncogene . https://doi.org/10.1038/s41388-021-01708-6
Mahajan, U.M., Alnatsha, A., Li, Q., Oehrle, B., Weiss, F.-U., Sendler, M.,... Mayerle, J. (2021). Plasma Metabolome Profiling Identifies Metabolic Subtypes of Pancreatic Ductal Adenocarcinoma . Cells , 10 (7). https://doi.org/10.3390/cells10071821
Mahajan, U.M., Alnatsha, A., Li, Q., Oehrle, B., Weiss, U., Sendler, M.,... Mayerle, J. (2021). Plasma Metabolic Profiling Identify Metabolic Subtypes of Pancreatic Ductal Adenocarcinoma . In PANCREAS (pp. 1079-1079). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Miquel Sedo, M., Zhang, S., & Pilarsky, C. (2021). Pre-clinical Models of Metastasis in Pancreatic Cancer . Frontiers in Cell and Developmental Biology , 9 . https://doi.org/10.3389/fcell.2021.748631
Parma, B., Ramesh, V., Gollavilli, P.N., Siddiqui, A., Pinna, L., Schwab, A.,... Ceppi, P. (2021). Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting . Journal of Experimental & Clinical Cancer Research , 40 (1). https://doi.org/10.1186/s13046-021-02049-8
Schwappacher, R., Dieterich, W., Reljic, D., Pilarsky, C., Mukhopadhyay, D., Chang, D.K.,... Zopf, Y. (2021). Muscle‐derived cytokines reduce growth, viability and migratory activity of pancreatic cancer cells . Cancers , 13 (15). https://doi.org/10.3390/cancers13153820
Zhou, W.-M., Yan, Y.-Y., Guo, Q.-R., Ji, H., Wang, H., Xu, T.-T.,... Zhang, J.-Y. (2021). Microfluidics applications for high-throughput single cell sequencing . Journal of Nanobiotechnology , 19 (1). https://doi.org/10.1186/s12951-021-01045-6
2020
Beyer, G., Adam, M.G., Christiansen, N., Kamlage, B., Pilarsky, C., Distler, M.,... Lerch, M.M. (2020). Development and Validation of a Multivariable Prediction Model Based on Blood Plasma and Serum Metabolomics for the Diagnosis of Chronic Pancreatitis . In PANCREAS (pp. 1401-1401). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Brunton, H., Caligiuri, G., Cunningham, R., Upstill-Goddard, R., Bailey, U.M., Garner, I.M.,... Bailey, P.J. (2020). HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer . Cell Reports , 31 (6). https://doi.org/10.1016/j.celrep.2020.107625
Friedrich, R.P., Schreiber, E., Tietze, R., Yang, H., Pilarsky, C., & Alexiou, C. (2020). Intracellular Quantification and Localization of Label-Free Iron Oxide Nanoparticles by Holotomographic Microscopy . Nanotechnology, Science and Applications , 13 , 119-130. https://doi.org/10.2147/NSA.S282204
Langheinrich, M., Wirtz, S., Kneis, B., Gittler, M.M., Tyc, O., Schierwagen, R.,... Weber, G. (2020). Microbiome Patterns in Matched Bile, Duodenal, Pancreatic Tumor Tissue, Drainage, and Stool Samples: Association with Preoperative Stenting and Postoperative Pancreatic Fistula Development . Journal of Clinical Medicine , 9 (9). https://doi.org/10.3390/jcm9092785
Mziaut, H., Henniger, G., Ganss, K., Hempel, S., Wolk, S., McChord, J.,... Kersting, S. (2020). MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling . Molecular Metabolism , 31 , 150-162. https://doi.org/10.1016/j.molmet.2019.11.012
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Contact:
We are working on the identification and validation of biomarker and target genes for pancreatic cancer. For this, we are handling the biobank of the surgical department and employing CRISPR/Cas9 and organoid technology.
Research projects
No projects found.
2024
2023
2022
2021
2020
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