Prof. Dr. Benoit Ladoux

2024

• Balasubramaniam, L., Jain, S., Dang, T., Lagoutte, E., Marc Mège, R., Chavrier, P.,... Rossé, C. (2024). Different Biomechanical Cell Behaviors in an Epithelium Drive Collective Epithelial Cell Extrusion. Advanced Science. https://doi.org/10.1002/advs.202401573

2023

• Eckert, J., Ladoux, B., Mège, R.M., Giomi, L., & Schmidt, T. (2023). Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-41449-6
• Kawaue, T., Yow, I., Pan, Y., Le, A.P., Lou, Y., Loberas, M.,... Toyama, Y. (2023). Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation. Developmental Cell, 58(4), 267-277.e5. https://doi.org/10.1016/j.devcel.2023.01.005
• Monteiro, P., Remy, D., Lemerle, E., Routet, F., Macé, A.S., Guedj, C.,... Chavrier, P. (2023). A mechanosensitive caveolae–invadosome interplay drives matrix remodelling for cancer cell invasion. Nature Cell Biology, 25(12), 1787-1803. https://doi.org/10.1038/s41556-023-01272-z
• Ron, J.E., d'Alessandro, J., Cellerin, V., Voituriez, R., Ladoux, B., & Gov, N.S. (2023). Polarization and motility of one-dimensional multi-cellular trains. Biophysical Journal, 122(23), 4598-4613. https://doi.org/10.1016/j.bpj.2023.11.003
• Rose, N., Estrada Chavez, B., Sonam, S., Nguyen, T., Grenci, G., Bigot, A.,... Trichet, L. (2023). Bioengineering a miniaturized in vitro 3D myotube contraction monitoring chip to model muscular dystrophies. Biomaterials, 293. https://doi.org/10.1016/j.biomaterials.2022.121935
• Sonam, S., Balasubramaniam, L., Lin, S.Z., Ivan, Y.M.Y., Pi-Jaumà, I., Jebane, C.,... Ladoux, B. (2023). Mechanical stress driven by rigidity sensing governs epithelial stability. Nature Physics, 19(1), 132-141. https://doi.org/10.1038/s41567-022-01826-2

2022

• Balasubramaniam, L., Mège, R.M., & Ladoux, B. (2022). Active nematics across scales from cytoskeleton organization to tissue morphogenesis. Current Opinion in Genetics & Development, 73. https://doi.org/10.1016/j.gde.2021.101897
• D'alessandro, J., Barbier-Chebbah, A., Voituriez, R., & Ladoux, B. (2022). Cells as « Tom Thumbs » of living tissues Les cellules, « Petits Poucets » des tissus vivants. M S-Medecine Sciences, 38(11), 861-863. https://doi.org/10.1051/medsci/2022138
• Doostmohammadi, A., & Ladoux, B. (2022). Physics of liquid crystals in cell biology. Trends in Cell Biology, 32(2), 140-150. https://doi.org/10.1016/j.tcb.2021.09.012
• Glentis, A., Blanch-Mercader, C., Balasubramaniam, L., Saw, T.B., d'Alessandro, J., Janel, S.,... Ladoux, B. (2022). The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces. Science Advances, 8(37). https://doi.org/10.1126/sciadv.abn5406
• Kabla, A., Ladoux, B., & Di Meglio, J.M. (2022). Tissue mechanics. European Physical Journal E, 45(11). https://doi.org/10.1140/epje/s10189-022-00240-z
• Petracchini, S., Hamaoui, D., Doye, A., Asnacios, A., Fage, F., Vitiello, E.,... Mettouchi, A. (2022). Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33803-x
• Yang, Y.A., Nguyen, E., Narayana, G.H.N.S., Heuzé, M., Fu, C., Yu, H.,... Sheetz, M.P. (2022). Local contractions regulate E-cadherin rigidity sensing. Science Advances, 8(4). https://doi.org/10.1126/sciadv.abk0387

2021

• Balasubramaniam, L., Doostmohammadi, A., Saw, T.B., Narayana, G.H.N.S., Mueller, R., Dang, T.,... Ladoux, B. (2021). Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers (Nature Materials, (2021), 20, 8, (1156-1166), 10.1038/s41563-021-00919-2). Nature Materials, 20(8), 1167-. https://doi.org/10.1038/s41563-021-00974-9
• Balasubramaniam, L., Doostmohammadi, A., Saw, T.B., Narayana, G.H.N.S., Mueller, R., Dang, T.,... Ladoux, B. (2021). Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nature Materials, 20(8), 1156-1166. https://doi.org/10.1038/s41563-021-00919-2
• Balasubramaniam, L., Mège, R.M., & Ladoux, B. (2021). Active forces modulate collective behaviour and cellular organization Des forces actives modulent le comportement collectif et l'organisation cellulaire. Comptes Rendus Biologies, 344(4), 325-335. https://doi.org/10.5802/crbiol.65
• Fardin, M.A., & Ladoux, B. (2021). Living proof of effective defects. Nature Physics, 17(2), 172-173. https://doi.org/10.1038/s41567-020-01084-0
• Gaston, C., De Beco, S., Doss, B., Pan, M., Gauquelin, E., D’Alessandro, J.,... Delacour, D. (2021). EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-22482-9
• Jain, S., Ladoux, B., & Mège, R.M. (2021). Mechanical plasticity in collective cell migration. Current Opinion in Cell Biology, 72, 54-62. https://doi.org/10.1016/j.ceb.2021.04.006
• Latorre, E., Kale, S., Casares, L., Gómez-González, M., Uroz, M., Valon, L.,... Trepat, X. (2021). Erratum: Addendum: Active superelasticity in three-dimensional epithelia of controlled shape (Nature (2018) 563 7730 (203-208)). Nature, 592(7856), E30-. https://doi.org/10.1038/s41586-021-03281-0
• Le, A.P., Rupprecht, J.F., Mège, R.M., Toyama, Y., Lim, C.T., & Ladoux, B. (2021). Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion. Nature Communications, 12(1). https://doi.org/10.1038/s41467-020-20563-9
• Sonam, S., Vigouroux, C., Jégou, A., Romet-Lemonne, G., Le Clainche, C., Ladoux, B., & Mège, R.M. (2021). Direct measurement of near-nano-Newton forces developed by self-organizing actomyosin fibers bound α-catenin. Biology of the Cell, 113(11), 441-449. https://doi.org/10.1111/boc.202100014
• d’Alessandro, J., Barbier--Chebbah, A., Cellerin, V., Benichou, O., Mège, R.M., Voituriez, R., & Ladoux, B. (2021). Cell migration guided by long-lived spatial memory. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24249-8

2020

• Balcioglu, H.E., Balasubramaniam, L., Stirbat, T.V., Doss, B.L., Fardin, M.A., Mège, R.M., & Ladoux, B. (2020). A subtle relationship between substrate stiffness and collective migration of cell clusters. Soft Matter, 16(7), 1825-1839. https://doi.org/10.1039/c9sm01893j
• Beauchesne, C.C., Chabanon, M., Smaniotto, B., Ladoux, B., Goyeau, B., & David, B. (2020). Channeling Effect and Tissue Morphology in a Perfusion Bioreactor Imaged by X-Ray Microtomography. Tissue Engineering and Regenerative Medicine, 17(3), 301-311. https://doi.org/10.1007/s13770-020-00246-8
• Doss, B.L., Pan, M., Gupta, M., Grenci, G., Mège, R.M., Lim, C.T.,... Ladoux, B. (2020). Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress. Proceedings of the National Academy of Sciences of the United States of America, 117(23), 12817-12825. https://doi.org/10.1073/pnas.1917555117
• Jain, S., Cachoux, V.M., Narayana, G.H., de Beco, S., D’Alessandro, J., Cellerin, V.,... Ladoux, B. (2020). The role of single-cell mechanical behaviour and polarity in driving collective cell migration. Nature Physics, 16(7), 802-809. https://doi.org/10.1038/s41567-020-0875-z
• Teo, J.L., Gomez, G.A., Weeratunga, S., Davies, E.M., Noordstra, I., Budnar, S.,... Yap, A.S. (2020). Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells. Developmental Cell, 54(1), 75-91.e7. https://doi.org/10.1016/j.devcel.2020.05.002
• Thomas, M., Ladoux, B., & Toyama, Y. (2020). Desmosomal Junctions Govern Tissue Integrity and Actomyosin Contractility in Apoptotic Cell Extrusion. Current Biology, 30(4), 682-690.e5. https://doi.org/10.1016/j.cub.2020.01.002
• Tlili, S., Durande, M., Gay, C., Ladoux, B., Graner, F., & Delanoë-Ayari, H. (2020). Migrating Epithelial Monolayer Flows like a Maxwell Viscoelastic Liquid. Physical Review Letters, 125(8). https://doi.org/10.1103/PhysRevLett.125.088102
• Xi, W., Delacour, D., & Ladoux, B. (2020). Designer substrates and devices for mechanobiology study. Journal of Semiconductors, 41(4). https://doi.org/10.1088/1674-4926/41/4/041607