Prof. Dr. Hans-Ulrich Prokosch

Research topics

Architecture, conception and management of state of the art hospital information systems
Telematic networking of the healthcare system
Evaluation of information systems in health care
Computer-based learning systems
WAIN knowledge base for a general drug information system with focus on intensive care medicine and nephrology
German Biobank Alliance: Development, testing and application of comprehensive, generic standards, products and solutions to enable the integration of German biobanks into BBMRI (Biobanking and Biomolecular Ressources Research Infrastructure)
MetropolMediplan 2016: Nationwide medication plan for Germany with cross-sectoral exchange of medication data between doctors and pharmacists

Center for AI in Medicine

(Own Funds)

Term: since 1. May 2024

→More information
INTERPOLAR: WP3 - Interventionelle Studie: Universitätsklinikum Erlangen

(Third Party Funds Group – Sub project)

Overall project: INTERPOLAR - Medizininformatik-Use Case "INTERventional POLypharmacy - drug interActions - Risks"
Term: 1. January 2023 - 31. December 2026
Funding source: BMBF / Verbundprojekt

→More information
Erschließung des transformativen Anwendungspotentials von TEAM-X in der palliativen Versorgung

(Third Party Funds Group – Sub project)

Overall project: Trusted Ecosystem of Applied Medical Data eXchange
Term: 1. January 2022 - 31. March 2025
Funding source: Bundesministerium für Wirtschaft und Klimaschutz (BMWK)
URL: https://www.palliativmedizin.uk-erlangen.de/forschung/klinisch-experimentelle-forschung/team-x/

→More information

2024

Ammon, D., Kurscheidt, M., Buckow, K., Kirsten, T., Löbe, M., Meineke, F.,... Ganslandt, T. (2024). Arbeitsgruppe Interoperabilität: Kerndatensatz und Informationssysteme für Integration und Austausch von Daten in der Medizininformatik-Initiative. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 67(6), 656-667. https://doi.org/10.1007/s00103-024-03888-4
Apfelbacher, T., Koçman, S.E., Prokosch, H.-U., & Christoph, J. (2024). A Governance Framework for the Implementation and Operation of AI Applications in a University Hospital. In John Mantas, Arie Hasman, George Demiris, Kaija Saranto, Michael Marschollek, Theodoros N. Arvanitis, Ivana Ognjanovic, Arriel Benis, Parisis Gallos, Emmanouil Zoulias, Elisavet Andrikopoulou (Eds.), Digital Health and Informatics Innovations for Sustainable Health Care Systems. Proceedings of MIE 2024 (pp. 776-780). Athens, GR: Amsterdam: IOS Press.
Bienzeisler, J., Perez-Garriga, A., Brandl, L.C., Kock-Schoppenhauer, A.-K., Hollenbenders, Y., Kurscheidt, M., & Schüttler, C. (2024). Report from the 68th GMDS Annual Meeting: ScienceClose to People. Methods of Information in Medicine, 62(5), 202-205. https://doi.org/10.1055/s-0043-1777733
Blasini, R., Strantz, C., Gulden, C., Helfer, S., Lidke, J., Prokosch, H.-U.,... Schneider, H. (2024). Evaluation of Eligibility Criteria Relevance for the Purpose of IT-Supported Trial Recruitment: Descriptive Quantitative Analysis. JMIR Formative Research, 8(1). https://doi.org/10.2196/49347
Boeker, M., Zöller, D., Blasini, R., Macho, P., Helfer, S., Behrens, M.,... Gulden, C. (2024). Effectiveness of IT-supported patient recruitment: study protocol for an interrupted time series study at ten German university hospitals. Trials, 25(1). https://doi.org/10.1186/s13063-024-07918-z
Engels, C., Kern, J., Dudová, Z., Deppenwiese, N., Kiel, A., Kroll, B.,... Prokosch, H.-U. (2024). The sample locator: A federated search tool for biosamples and associated data in Europe using HL7 FHIR. Computers in Biology and Medicine, 180. https://doi.org/10.1016/j.compbiomed.2024.108941
Gierend, K., Krüger, F., Genehr, S., Hartmann, F., Siegel, F., Waltemath, D.,... Zeleke, A.A. (2024). Provenance Information for Biomedical Data and Workflows: Scoping Review. Journal of Medical Internet Research, 26(1). https://doi.org/10.2196/51297
Grönberg, C., Rattik, S., Tran-Manh, C., Zhou, X., Rius Rigau, A.R., Li, Y.N.,... Trinh-Minh, T. (2024). Combined inhibition of IL-1, IL-33 and IL-36 signalling by targeting IL1RAP ameliorates skin and lung fibrosis in preclinical models of systemic sclerosis. Annals of the Rheumatic Diseases. https://doi.org/10.1136/ard-2023-225158
Gulden, C., Macho, P., Reinecke, I., Strantz, C., Prokosch, H.-U., & Blasini, R. (2024). recruIT: A cloud-native clinical trial recruitment support system based on Health Level 7 Fast Healthcare Interoperability Resources (HL7 FHIR) and the Observational Medical Outcomes Partnership Common Data Model (OMOP CDM). Computers in Biology and Medicine, 174. https://doi.org/10.1016/j.compbiomed.2024.108411
Györfi, A.H., Filla, T., Dickel, N., Möller, F., Li, Y.N., Bergmann, C.,... Distler, J.H. (2024). Performance of serum biomarkers reflective of different pathogenic processes in systemic sclerosis-associated interstitial lung disease. Rheumatology, 63(4), 962-969. https://doi.org/10.1093/rheumatology/kead332
Hiltner, M., Gulden, C., & Toddenroth, D. (2024). Classification of Veterinary Subjects in Medical Literature and Clinical Summaries. In Rainer Rohrig, Niels Grabe, Ursula Hertha Hubner, Klaus Jung, Ulrich Sax, Carsten Oliver Schmidt, Martin Sedlmayr, Antonia Zapf (Eds.), Studies in Health Technology and Informatics (pp. 210-217). Dresden, DEU: IOS Press BV.
Jelodari Mamaghani, S., Strantz, C., & Toddenroth, D. (2024). Classifiers of Data Sharing Statements in Clinical Trial Records. In John Mantas, Arie Hasman, George Demiris, Kaija Saranto, Michael Marschollek, Theodoros N. Arvanitis, Ivana Ognjanovic, Arriel Benis, Parisis Gallos, Emmanouil Zoulias, Elisavet Andrikopoulou (Eds.), Digital Health and Informatics Innovations for Sustainable Health Care Systems. Proceedings of MIE 2024 (pp. 834-838). Athens, GR: Amsterdam: IOS Press BV.
Kapsner, L., Folle, L., Hadler, D., Eberle, J., Balbach, E., Liebert, A.,... Bickelhaupt, S. (2024). Lesion-conditioning of synthetic MRI-derived subtraction-MIPs of the breast using a latent diffusion model. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-56853-1
Kleinert, P., Gebhardt, M., Buckow, K., Gründner, J., Ganslandt, T., Prokosch, H.-U., & Semler, S.C. (2024). Germany's Approach for the Secondary Use of Federated Real-World Data in the German Portal for Medical Research Data. In John Mantas, Arie Hasman, George Demiris, Kaija Saranto, Michael Marschollek, Theodoros N. Arvanitis, Ivana Ognjanovic, Arriel Benis, Parisis Gallos, Emmanouil Zoulias, Elisavet Andrikopoulou (Eds.), Studies in Health Technology and Informatics (pp. 1704-1708). Athens, GRC: IOS Press BV.
Krefting, D., Bavendiek, U., Fischer, J., Marx, G., Molinnus, D., Panholzer, T.,... Sedlmayr, M. (2024). Die digitalen Fortschrittshubs Gesundheit – Gemeinsame Datennutzung über die Universitätsmedizin hinaus. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 67(6), 701-709. https://doi.org/10.1007/s00103-024-03883-9
Laininger, L., Dietzel, N., Grässel, E., Prokosch, H.-U., & Kolominsky-Rabas, P. (2024). Impact of social network composition on cognitive decline: Digital Dementia Registry Bavaria (digiDEM Bayern). PLoS ONE, 19(7). https://doi.org/10.1371/journal.pone.0306447
Liang, M., Dickel, N., Györfi, A.H., SafakTümerdem, B., Li, Y.N., Rius Rigau, A.R.,... Distler, J.H. (2024). Attenuation of fibroblast activation and fibrosis by adropin in systemic sclerosis. Science Translational Medicine, 16(740). https://doi.org/10.1126/scitranslmed.add6570
Manuilova, I., Bossenz, J., Weise, A.B., Böhm, D., Strantz, C., Unberath, P.,... Christoph, J. (2024). Identifications of Similarity Metrics for Patients With Cancer: Protocol for a Scoping Review. JMIR Research Protocols, 13. https://doi.org/10.2196/58705
Moorthy, P., Weinert, L., Schüttler, C., Svensson, L., Sedlmayr, B., Müller, J., & Nagel, T. (2024). Attributes, Methods, and Frameworks Used to Evaluate Wearables and Their Companion mHealth Apps: Scoping Review. JMIR mHealth and uHealth, 12, e52179-. https://doi.org/10.2196/52179
Myin-Germeys, I., Schick, A., Ganslandt, T., Hajdúk, M., Heretik, A., Van Hoyweghen, I.,... Reininghaus, U. (2024). The experience sampling methodology as a digital clinical tool for more person-centered mental health care: an implementation research agenda. Psychological Medicine. https://doi.org/10.1017/S0033291724001454
Negash, S., Gundlack, J., Buch, C., Apfelbacher, T., Christoph, J., Schildmann, J.,... Mikolajczyk, R. (2024). Physicians' Attitudes Towards Artificial Intelligence: Results of the PEAK Project. In John Mantas, Arie Hasman, George Demiris, Kaija Saranto, Michael Marschollek, Theodoros N. Arvanitis, Ivana Ognjanovic, Arriel Benis, Parisis Gallos, Emmanouil Zoulias, Elisavet Andrikopoulou (Eds.), Digital Health and Informatics Innovations for Sustainable Health Care Systems. Proceedings of MIE 2024 (pp. 664-665). Athens, GR: Amsterdam: IOS Press.
Roehnisch, T., Martos-Contreras, M.C., Manoochehri, M., Nogueira, M., Bremm, F., Dörrie, J.,... Schönharting, W. (2024). Individualized neoantigen peptide immunization of a metastatic pancreatic cancer patient: a case report of combined tumor and liquid biopsy. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1414737
Rosenau, L., Behrend, P., Wiedekopf, J., Gründner, J., & Ingenerf, J. (2024). Uncovering Harmonization Potential in Health Care Data Through Iterative Refinement of Fast Healthcare Interoperability Resources Profiles Based on Retrospective Discrepancy Analysis: Case Study. JMIR Medical Informatics, 12. https://doi.org/10.2196/57005
Rödle, W., Prokosch, H.-U., Neumann, E., Toni, I., Haering-Zahn, J., Neubert, A., & Eberl, S. (2024). Creating a Medication Therapy Observational Research Database from an Electronic Medical Record: Challenges and Data Curation. Applied Clinical Informatics, 15(1), 111-118. https://doi.org/10.1055/s-0043-1777741
Schneider, Y., Gauer, C., Andert, M., Hoffmann, A., Riemenschneider, M.J., Krebs, W.,... Winkler, J. (2024). Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy. Acta Neuropathologica Communications, 12(1). https://doi.org/10.1186/s40478-023-01699-3
Semler, S.C., Boeker, M., Eils, R., Krefting, D., Loeffler, M., Bussmann, J.,... Prokosch, H.-U. (2024). Die Medizininformatik-Initiative im Überblick – Aufbau einer Gesundheitsforschungsdateninfrastruktur in Deutschland. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 67(6), 616-628. https://doi.org/10.1007/s00103-024-03887-5
Trinh-Minh, T., Györfi, A.H., Tomcik, M., Tran-Manh, C., Zhou, X., Dickel, N.,... Distler, J.H. (2024). Effect of Anti-S100A4 Monoclonal Antibody Treatment on Experimental Skin Fibrosis and Systemic Sclerosis–Specific Transcriptional Signatures in Human Skin. Arthritis and Rheumatology, 76(5), 783-795. https://doi.org/10.1002/art.42781
Zeiler, M., Dietzel, N., Kolominsky-Rabas, P., Grässel, E., & Prokosch, H.-U. (2024). Evaluation of a Digital Dementia Registry's IT Architecture After a Three-Year Period in Practice: digiDEM Bayern. Studies in health technology and informatics, 313, 43-48. https://doi.org/10.3233/SHTI240010

2023

Ammer, T., Schützenmeister, A., Prokosch, H.-U., Rauh, M., Rank, C.M., & Zierk, J. (2023). A pipeline for the fully automated estimation of continuous reference intervals using real-world data. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-40561-3
Ammer, T., Schützenmeister, A., Rank, C.M., & Doyle, K. (2023). Estimation of Reference Intervals from Routine Data Using the refineR Algorithm-A Practical Guide. The Journal of Applied Laboratory Medicine, 8(1), 84-91. https://dx.doi.org/10.1093/jalm/jfac101
Cao, S., Li, Y., Song, R., Meng, X., Fuchs, M., Liang, C.,... Bozec, A. (2023). L-Arginine metabolism inhibits arthritis and inflammatory bone loss. Annals of the Rheumatic Diseases. https://doi.org/10.1136/ard-2022-223626
Dandekar, T., & Kunz, M. (2023). Bioinformatics: An Introductory Textbook. Springer Berlin Heidelberg.
Gierend, K., Freiesleben, S., Kadioglu, D., Siegel, F., Ganslandt, T., & Waltemath, D. (2023). The Status of Data Management Practices Across German Medical Data Integration Centers: Mixed Methods Study. Journal of Medical Internet Research, 25, e48809-. https://doi.org/10.2196/48809
Haeckel, R., Ammer, T., Wosniok, W., Krebs, A., Torge, A., Oezcueruemez, M., & Bertram, A. (2023). Age-and sex-specific reference intervals of total cholesterol, LDL cholesterol, HDL cholesterol and non-HDL cholesterol. Comparison of two algorithms for the indirect estimation of reference intervals. Journal of Laboratory Medicine. https://dx.doi.org/10.1515/labmed-2022-0147
Heger, L., Hatscher, L., Liang, C., Lehmann, C., Amon, L., Lühr, J.J.,... Dudziak, D. (2023). XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors. Proceedings of the National Academy of Sciences of the United States of America, 120(33), e2300343120. https://doi.org/10.1073/pnas.2300343120
Hueber, S., Biermann, V., Tomandl, J., Warkentin, L., Schedlbauer, A., Tauchmann, H.,... Kühlein, T. (2023). Consequences of early thyroid ultrasound on subsequent tests, morbidity and costs: an explorative analysis of routine health data from German ambulatory care. BMJ Open, 13(3). https://doi.org/10.1136/bmjopen-2021-059016
Iancu, A., Leb, I., Prokosch, H.-U., & Rödle, W. (2023). Machine learning in medication prescription: A systematic review. International Journal of Medical Informatics, 180. https://doi.org/10.1016/j.ijmedinf.2023.105241
Keefer, A., Steichele, K., Grässel, E., Prokosch, H.-U., & Kolominsky-Rabas, P. (2023). Does Voluntary Work Contribute to Cognitive Performance? – An International Systematic Review. Journal of Multidisciplinary Healthcare, 16, 1097-1109. https://doi.org/10.2147/JMDH.S404880
Keimer, M., Villis, M., Christoph, J., & Rödle, W. (2023). Demand Analysis of a German Emergency Medical Service Feedback System. In Rainer Röhrig, Niels Grabe, Martin Haag, Ursula Hübner, Ulrich Sax, Carsten Oliver Schmidt, Martin Sedlmayr, Antonia Zapf (Eds.), German Medical Data Sciences 2023 – Science. Close to People. (pp. 102-109). IOS Press.
Kim, H.E., Maros, M.E., Miethke, T., Kittel, M., Siegel, F., & Ganslandt, T. (2023). Lightweight Visual Transformers Outperform Convolutional Neural Networks for Gram-Stained Image Classification: An Empirical Study. Biomedicines, 11(5). https://doi.org/10.3390/biomedicines11051333
Krug, J., Rodrian, G., Petter, K., Yang, H., Khoziainova, S., Guo, W.,... Britzen-Laurent, N. (2023). N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy. Gastroenterology. https://doi.org/10.1053/j.gastro.2022.11.018
Mang, J., Prokosch, H.-U., & Kapsner, L. (2023). Reproducibility in 2023 - An End-to-End Template for Analysis and Manuscript Writing. Studies in health technology and informatics, 302, 58-62. https://doi.org/10.3233/SHTI230064
Metzger, P., Hess, M.E., Blaumeiser, A., Pauli, T., Schipperges, V., Mertes, R.,... Boerries, M. (2023). MIRACUM-Pipe: An Adaptable Pipeline for Next-Generation Sequencing Analysis, Reporting, and Visualization for Clinical Decision Making. Cancers, 15(13). https://doi.org/10.3390/cancers15133456
Naschberger, E., Fuchs, M., Dickel, N., Kunz, M., Popp, B., Anchang, C.G.,... Stürzl, M. (2023). Tumor microenvironment-dependent epigenetic imprinting in the vasculature predicts colon cancer outcome. Cancer Communications. https://doi.org/10.1002/cac2.12489
Prokosch, H.-U., Gebhardt, M., Gründner, J., Kleinert, P., Buckow, K., Rosenau, L., & Semler, S.C. (2023). Towards a National Portal for Medical Research Data (FDPG): Vision, Status, and Lessons Learned. In Maria Hägglund, Madeleine Blusi, Stefano Bonacina, Lina Nilsson, Inge Cort Madsen, Sylvia Pelayo, Anne Moen, Arriel Benis, Lars Lindsköld, Parisis Gallos (Eds.), Caring is Sharing – Exploiting the Value in Data for Health and Innovation. (pp. 307-311). IOS Press.
Reimer, K.C., Nadal, J., Meiselbach, H., Schmid, M., Schultheiss, U.T., Kotsis, F.,... Gronwald, W. (2023). Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease (GCKD) cohort. Bone Research, 11(1). https://doi.org/10.1038/s41413-023-00291-8
Schmidtchen, L., Villis, M., Christoph, J., & Rödle, W. (2023). Usability Analysis of a Medication Visualization Tool for Decision Support. In Rainer Röhrig, Niels Grabe, Martin Haag, Ursula Hübner, Ulrich Sax, Carsten Oliver Schmidt, Martin Sedlmayr, Antonia Zapf (Eds.), German Medical Data Sciences 2023 – Science. Close to People. (pp. 110-116). IOS Press.
Schüttler, C., & Ulrich, H. (2023). Support of Young Talent in the GMDS. In Maria Hägglund, Madeleine Blusi, Stefano Bonacina, Lina Nilsson, Inge Cort Madsen, Sylvia Pelayo, Anne Moen, Arriel Benis, Lars Lindsköld, Parisis Gallos (Eds.), Caring is Sharing – Exploiting the Value in Data for Health and Innovation. (pp. 484-485). IOS Press.
Schüttler, C., Zerlik, M., Gründner, J., Köhler, T., Rosenau, L., Prokosch, H.-U., & Sedlmayr, B. (2023). Empowering Researchers to Query Medical Data and Biospecimens by Ensuring Appropriate Usability of a Feasibility Tool: Evaluation Study. JMIR Human Factors, 10. https://doi.org/10.2196/43782
Seeling, M., Pöhnl, M., Kara, S., Horstmann, N., Riemer, C.D., Wöhner, M.,... Nimmerjahn, F. (2023). Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1. Immunity, 56(5), 1046-1063.e7. https://doi.org/10.1016/j.immuni.2023.02.019
Toddenroth, D. (2023). Classifiers of Medical Eponymy in Scientific Texts. In Maria Hägglund, Madeleine Blusi, Stefano Bonacina, Lina Nilsson, Inge Cort Madsen, Sylvia Pelayo, Anne Moen, Arriel Benis, Lars Lindsköld, Parisis Gallos (Eds.), Caring is Sharing – Exploiting the Value in Data for Health and Innovation. (pp. 808-812). IOS Press.
Wabo, G.K., Prasser, F., Gierend, K., Siegel, F., & Ganslandt, T. (2023). Data Quality– and Utility-Compliant Anonymization of Common Data Model–Harmonized Electronic Health Record Data: Protocol for a Scoping Review. JMIR Research Protocols, 12. https://doi.org/10.2196/46471
Wolfien, M., Ahmadi, N., Fitzer, K., Grummt, S., Heine, K.L., Jung, I.C.,... Sedlmayr, M. (2023). Ten Topics to Get Started in Medical Informatics Research. Journal of Medical Internet Research, 25, e45948-. https://doi.org/10.2196/45948
Zeiler, M., Chmelirsch, C., Dietzel, N., & Kolominsky-Rabas, P. (2023). Wissenschaftliche Evidenz und Nutzerqualität von Mobile-Health-Anwendungen für Menschen mit kognitiven Beeinträchtigungen und deren Angehörige. Zeitschrift für Evidenz, Fortbildung und Qualitat im Gesundheitswesen. https://doi.org/10.1016/j.zefq.2023.01.003
Ziegler, J., Gründner, J., Rosenau, L., Erpenbeck, M., Prokosch, H.-U., & Deppenwiese, N. (2023). Towards a Bavarian Oncology Real World Data Research Platform. In Rainer Röhrig, Niels Grabe, Martin Haag, Ursula Hübner, Ulrich Sax, Carsten Oliver Schmidt, Martin Sedlmayr, Antonia Zapf (Eds.), German Medical Data Sciences 2023 – Science. Close to People. (pp. 78-85). IOS Press.

2022

Ammer, T., Schuetzenmeister, A., Prokosch, H.-U., Zierk, J., Rank, C.M., & Rauh, M. (2022). RIbench: A Proposed Benchmark for the Standardized Evaluation of Indirect Methods for Reference Interval Estimation. Clinical Chemistry. https://doi.org/10.1093/clinchem/hvac142
Ammer, T., Schutzenmeister, A., Prokosch, H.-U., Rauh, M., Zierk, J., & Rank, C.M. (2022). Enhancing refiner - Improving performance of reference interval estimation for skewed distributions. In CLINICA CHIMICA ACTA (pp. S294-S294). AMSTERDAM: ELSEVIER.
Bialke, M., Geidel, L., Hampf, C., Blumentritt, A., Penndorf, P., Schuldt, R.,... Hoffmann, W. (2022). A FHIR has been lit on gICS: facilitating the standardised exchange of informed consent in a large network of university medicine. BMC Medical Informatics and Decision Making, 22(1). https://doi.org/10.1186/s12911-022-02081-4
Cao, S., Song, R., Meng, X., Kachler, K., Fuchs, M., Meng, X.,... Bozec, A. (2022). L-ARGININE REPROGRAMS OSTEOCLAST PURINE METABOLISM AMELIORATING BONE LOSS IN RHEUMATOID ARTHRITIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 52-52). LONDON: BMJ PUBLISHING GROUP.
Fitzer, K., Haeuslschmid, R., Blasini, R., Altun, F.B., Hampf, C., Freiesleben, S.,... Gulden, C. (2022). Patient Recruitment System for Clinical Trials: Mixed Methods Study About Requirements at Ten University Hospitals. JMIR Medical Informatics, 10(4). https://doi.org/10.2196/28696
Gronberg, C., Rattik, S., Kunz, M., Thoung Trinh-Minh, ., TRAN MANH, C., Zhou, X.,... Distler, J. (2022). Blocking IL-1, IL-33 and IL-36 Signaling with the Anti-IL1RAP Antibody mCAN10 Ameliorates Inflammation and Fibrosis in Preclinical Models of Systemic Sclerosis. In ARTHRITIS & RHEUMATOLOGY (pp. 3227-3228). HOBOKEN: WILEY.
Gründner, J., Deppenwiese, N., Folz, M., Koehler, T., Kroll, B., Prokosch, H.-U.,... Majeed, R.W. (2022). The Architecture of a Feasibility Query Portal for Distributed COVID-19 Fast Healthcare Interoperability Resources (FHIR) Patient Data Repositories: Design and Implementation Study. JMIR Medical Informatics, 10(5). https://doi.org/10.2196/36709
Güngör, B., Deppenwiese, N., Mang, J.M., & Toddenroth, D. (2022). Analysis of the Representation of Frequent Clinical Attributes in the Unified Medical Language System. In Bernd Blobel, Bian Yang, Mauro Giacomini (Eds.), pHealth 2022. (pp. 217-222).
Heger, L., Hatscher, L., Lehmann, C., Purbojo, A., Onderka, C., Liang, C.,... Dudziak, D. (2022). Select hyperactivating NLRP3 ligands enhance the TH1-and TH17-inducing potential of human type 2 conventional dendritic cells. In EXPERIMENTAL DERMATOLOGY (pp. E75-E76). HOBOKEN: WILEY.
Holweg, F., Achenbach, S., Deppenwiese, N., Gaede, L., & Prokosch, H.-U. (2022). Towards a FHIR-Based Data Model for Coronary Angiography Observations. In Thomas Bürkle, Kerstin Denecke, Jürgen Holm, Murat Sariyar, Michael Lehmann (Eds.), Healthcare of the Future 2022. (pp. 96-99). IOS Press.
Holzner, D., Apfelbacher, T., Rödle, W., Schüttler, C., Prokosch, H.-U., Mikolajczyk, R.,... Christoph, J. (2022). Attitudes and Acceptance Towards Artificial Intelligence in Medical Care. Studies in health technology and informatics, 294, 68-72. https://doi.org/10.3233/SHTI220398
Kapsner, L., Brunner, T., Christiansen, H., Kisser, U., Mansoorian, S., Prokosch, H.-U.,... Medenwald, D. (2022). Postponements in Use of Radiotherapy during the first Wave of the COVID-19 Pandemic? An Analysis of Hospital Data. In STRAHLENTHERAPIE UND ONKOLOGIE (pp. S43-S43). HEIDELBERG: SPRINGER HEIDELBERG.
Leb, I., Magnin, S., Boeker, M., Prokosch, H.-U., Ammenwerth, E., & Glöggler, M. (2022). Classification of Patient Portals Described in Evaluation Studies Using the TOPCOP Taxonomy. In Thomas Bürkle, Kerstin Denecke, Jürgen Holm, Murat Sariyar, Michael Lehmann (Eds.), Healthcare of the Future 2022. (pp. 28-33).
Löbe, M., Bialke, M., Bienzeisler, J., Drepper, J., Ganslandt, T., Haderer, S.,... Kaulke, K. (2022). ToolPool Gesundheitsforschung - A Repository for Software and Services Focused on Supporting Clinical and Epidemiological Research. Studies in health technology and informatics, 293, 19-27. https://doi.org/10.3233/SHTI220342
Mang, J.M., Seuchter, S.A., Gulden, C., Schild, S., Kraska, D., Prokosch, H.-U., & Kapsner, L. (2022). DQAgui: a graphical user interface for the MIRACUM data quality assessment tool. BMC Medical Informatics and Decision Making, 22(1). https://doi.org/10.1186/s12911-022-01961-z
Medenwald, D., Brunner, T., Christiansen, H., Kisser, U., Mansoorian, S., Vordermark, D.,... Kapsner, L. (2022). Shift of radiotherapy use during the first wave of the COVID-19 pandemic? An analysis of German inpatient data. Strahlentherapie und Onkologie. https://doi.org/10.1007/s00066-021-01883-1
Pontones, M., Hoefener, H., Kock, F., Schwen, L., Westphal, M., Dickel, N.,... Metzler, M. (2022). Comprehensive bone marrow analysis integrating deep learning-based pattern discovery (BMDeep). In KLINISCHE PADIATRIE (pp. 190-190). STUTTGART: GEORG THIEME VERLAG KG.
Prokosch, H.-U., Baber, R., Bollmann, P., Gebhardt, M., Gründner, J., & Hummel, M. (2022). Aligning Biobanks and Data Integration Centers Efficiently (ABIDE_MI). In Thomas Bürkle, Kerstin Denecke, Jürgen Holm, Murat Sariyar, Michael Lehmann (Eds.), Healthcare of the Future 2022. (pp. 37-42). IOS Press.
Prokosch, H.-U., Bahls, T., Bialke, M., Eils, J., Fegeler, C., Gründner, J.,... Eils, R. (2022). The COVID-19 Data Exchange Platform of the German University Medicine. In Brigitte Séroussi, Patrick Weber, Ferdinand Dhombres, Cyril Grouin, Jan-David Liebe, Sylvia Pelayo, Andrea Pinna, Bastien Rance, Lucia Sacchi, Adrien Ugon, Arriel Benis, Parisis Gallos (Eds.), Challenges of Trustable AI and Added-Value on Health. (pp. 674-678). IOS Press.
Rosenau, L., Majeed, R.W., Ingenerf, J., Kiel, A., Kroll, B., Köhler, T.,... Gründner, J. (2022). Generation of a Fast Healthcare Interoperability Resources (FHIR)-based Ontology for Federated Feasibility Queries in the Context of COVID-19: Feasibility Study. JMIR Medical Informatics, 10(4). https://doi.org/10.2196/35789
Scheible, R., Caliskan, D., Fischer, P., Thomczyk, F., Zabka, S., Schneider, H.,... Gulden, C. (2022). AHD2FHIR: A Tool for Mapping of Natural Language Annotations to Fast Healthcare Interoperability Resources - A Technical Case Report. Studies in health technology and informatics, 290, 32-36. https://doi.org/10.3233/SHTI220026
Scheiter, A., Hierl, F., Lueke, F., Keil, F., Heudobler, D., Einhell, S.,... Utpatel, K. (2022). Critical evaluation of molecular tumour board outcomes following 2 years of clinical practice in a Comprehensive Cancer Centre. British Journal of Cancer. https://doi.org/10.1038/s41416-022-02120-x
Schoenthaler, M., Fichtner, U.A., Boeker, M., Zoeller, D., Binder, H., Prokosch, H.-U.,... Farin-Glattacker, E. (2022). A nationwide registry for recurrent urolithiasis in the upper urinary tract - The RECUR study protocol. BMC Health Services Research, 22(1). https://doi.org/10.1186/s12913-022-08375-7
Schüttler, C., Jahns, R., Prokosch, H.-U., Wach, S., & Wullich, B. (2022). Biobanks, translational research and medical informatics. Die Urologie, 61(7), 722-727. https://doi.org/10.1007/s00120-022-01850-3
Sedlmayr, B., Sedlmayr, M., Kroll, B., Prokosch, H.-U., Gründner, J., & Schüttler, C. (2022). Improving COVID-19 Research of University Hospitals in Germany: Formative Usability Evaluation of the CODEX Feasibility Portal. Applied Clinical Informatics, 13(02), 400-409. https://doi.org/10.1055/s-0042-1744549
Steichele, K., Keefer, A., Dietzel, N., Grässel, E., Prokosch, H.-U., & Kolominsky-Rabas, P. (2022). The effects of exercise programs on cognition, activities of daily living, and neuropsychiatric symptoms in community-dwelling people with dementia-a systematic review. Alzheimer's Research and Therapy, 14(1). https://doi.org/10.1186/s13195-022-01040-5
Symanzik, C., Johansen, J.D., Weinert, P., Babić, Ž., Hallmann, S., Havmose, M.S.,... Uter, W. (2022). Differences between hairdressers and consumers in skin exposure to hair cosmetic products: A review. Contact Dermatitis. https://doi.org/10.1111/cod.14055
Symanzik, C., Weinert, P., Babić, Ž., Hallmann, S., Havmose, M.S., Johansen, J.D.,... Uter, W. (2022). Allergic contact dermatitis caused by 2-hydroxyethyl methacrylate and ethyl cyanoacrylate contained in cosmetic glues among hairdressers and beauticians who perform nail treatments and eyelash extension as well as hair extension applications: A systematic review. Contact Dermatitis. https://doi.org/10.1111/cod.14056
Toddenroth, D. (2022). Evaluation of Domain-Specific Word Vectors for Biomedical Word Sense Disambiguation. In Thomas Bürkle, Kerstin Denecke, Jürgen Holm, Murat Sariyar, Michael Lehmann (Eds.), Healthcare of the Future 2022. (pp. 23-27). IOS Press.
Ulrich, H., Kock-Schoppenhauer, A.-K., Deppenwiese, N., Gött, R., Kern, J., Lablans, M.,... Ingenerf, J. (2022). Understanding the Nature of Metadata: Systematic Review. Journal of Medical Internet Research, 24(1). https://doi.org/10.2196/25440
Unberath, P., Mahlmeister, L., Reimer, N., Busch, H., Boerries, M., & Christoph, J. (2022). Searching of Clinical Trials Made Easier in cBioPortal Using Patients' Genetic and Clinical Profiles. Applied Clinical Informatics, 13(2), 363-369. https://doi.org/10.1055/s-0042-1743560
Vass, A., Reinecke, I., Boeker, M., Prokosch, H.-U., & Gulden, C. (2022). Availability of Structured Data Elements in Electronic Health Records for Supporting Patient Recruitment in Clinical Trials. Studies in health technology and informatics, 290, 130-134. https://doi.org/10.3233/SHTI220046
Weber, G.M., Hong, C., Xia, Z., Palmer, N.P., Avillach, P., L'Yi, S.,... Brat, G.A. (2022). International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality. npj Digital Medicine, 5(1). https://doi.org/10.1038/s41746-022-00601-0
Zeiler, M., Chmelirsch, C., & Kolominsky-Rabas, P. (2022). Assessment of functionality and scientific evidence of mobile health applications (mHealth apps) for people with dementia and their caregivers. In EUROPEAN PSYCHIATRY (pp. S169-S170). CAMBRIDGE: CAMBRIDGE UNIV PRESS.

2021

Ammer, T., Schuetzenmeister, A., Prokosch, H.-U., Rauh, M., Rank, C.M., & Zierk, J. (2021). refineR: A Novel Algorithm for Reference Interval Estimation from Real-World Data. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-95301-2
Amr, A., Hinderer, M., Griebel, L., Deuber, D., Egger, C., Sedaghat-Hamedani, F.,... Meder, B. (2021). Controlling my genome with my smartphone: first clinical experiences of the PROMISE system. Clinical Research in Cardiology. https://doi.org/10.1007/s00392-021-01942-8
Caliskan, D., Zierk, J., Kraska, D., Schulz, S., Daumke, P., Prokosch, H.-U., & Kapsner, L. (2021). First Steps to Evaluate an NLP Tool's Medication Extraction Accuracy from Discharge Letters. In Rainer Röhrig, Tim Beißbarth, Werner Brannath, Hans-Ulrich Prokosch, Irene Schmidtmann, Susanne Stolpe, Antonia Zapf (Eds.), German Medical Data Sciences: Bringing Data to Life. (pp. 224-230). IOS Press.
Dees, C., Pötter, S., Fuchs, M., Bergmann, C., Matei, A.-E., Györfi, A.-H.,... Distler, H.W. (2021). NCOA3 AMPLIFIES PROFIBROTIC TRANSCRIPTIONAL PROGRAMS IN SYSTEMIC SCLEROSIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 440-441). LONDON: BMJ PUBLISHING GROUP.
Deppenwiese, N., Delpy, P., Lambarki, M., & Lablans, M. (2021). ADT2FHIR a tool for converting ADT/GEKID oncology data to HL7 FHIR resources. In Rainer Rohrig, Tim Beissbarth, Jochem Konig, Claudia Ose, Geraldine Rauch, Ulrich Sax, Bjorn Schreiweis, Martin Sedlmayr (Eds.), Studies in Health Technology and Informatics (pp. 104-110). Virtual, Online, DEU: IOS Press BV.
Dietzel, N., Kürten, L., Karrer, L., Reichold, M., Köhler, L., Nagel, A.,... Kolominsky-Rabas, P. (2021). Digital Dementia Registry Bavaria - DigiDEM Bayern: Study protocol for a multicentre, prospective, longitudinal register study. BMJ Open, 11(2). https://doi.org/10.1136/bmjopen-2020-043473
Faas, M., Ipseiz, N., Ackermann, J., Culemann, S., Grüneboom, A., Schröder, F.,... Krönke, G. (2021). IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. Immunity, 54(11), 2531-2546.e5. https://doi.org/10.1016/j.immuni.2021.09.010
Gründner, J., Gulden, C., Kampf, M., Mate, S., Prokosch, H.-U., & Zierk, J. (2021). A framework for criteria-based selection and processing of fast healthcare interoperability resources (FHIR) data for statistical analysis: Design and implementation study. JMIR Medical Informatics, 9(4). https://doi.org/10.2196/25645
Gulden, C., Blasini, R., Nassirian, A., Stein, A., Altun, F.B., Kirchner, M.,... Boeker, M. (2021). Prototypical clinical trial registry based on fast healthcare interoperability resources (FHIR): Design and implementation study. JMIR Medical Informatics, 9(1). https://doi.org/10.2196/20470
Györfi, A.-H., Matei, A.-E., Fuchs, M., Liang, C., Rigau, A., Hong, X.,... Distler, J. (2021). Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation. Journal of Experimental Medicine, 218(9). https://doi.org/10.1084/jem.20201916
Györfi, A.-H., Matei, A.-E., Fuchs, M., Rigau, A., Hong, X., Honglin, Z.,... Distler, J. (2021). ENGRAILED 1 COORDINATES CYTOSKELETAL ORGANIZATION TO PROMOTE MYOFIBROBLAST DIFFERENTIATION AND FIBROTIC TISSUE REMODELING. In ANNALS OF THE RHEUMATIC DISEASES (pp. 391-391). LONDON: BMJ PUBLISHING GROUP.
Hatscher, L., Lehmann, C., Purbojo, A., Onderka, C., Liang, C., Hartmann, A.,... Dudziak, D. (2021). Select hyperactivating NLRP3 ligands enhance the TH1-and TH17-inducing potential of human type 2 conventional dendritic cells. Science Signaling, 14(680), 1-17. https://doi.org/10.1126/scisignal.abe1757
Huber, T., Steininger, P., Irrgang, P., Korn, K., Tenbusch, M., Diesch, K.,... Held, J. (2021). Correction to: Diagnostic performance of four SARS-CoV-2 antibody assays in patients with COVID-19 or with bacterial and non-SARS-CoV-2 viral respiratory infections (European Journal of Clinical Microbiology & Infectious Diseases, (2021), 10.1007/s10096-021-04285-4). European Journal of Clinical Microbiology & Infectious Diseases. https://doi.org/10.1007/s10096-021-04301-7
Kapsner, L., Kampf, M., Seuchter, S.A., Gründner, J., Gulden, C., Mate, S.,... Prokosch, H.-U. (2021). Reduced Rate of Inpatient Hospital Admissions in 18 German University Hospitals During the COVID-19 Lockdown. Frontiers in Public Health, 8. https://doi.org/10.3389/fpubh.2020.594117
Kapsner, L., Mang, J.M., Mate, S., Seuchter, S.A., Vengadeswaran, A., Bathelt, F.,... Prokosch, H.-U. (2021). Linking a Consortium-Wide Data Quality Assessment Tool with the MIRACUM Metadata Repository. Applied Clinical Informatics, 12(04), 826-835. https://doi.org/10.1055/s-0041-1733847
Kapsner, L., Zavgorodnij, M.G., Majorova, S.P., Hotz-Wagenblatt, A., Kolychev, O.V., Lebedev, I.N.,... Moskalev, E. (2021). BiasCorrector: Fast and accurate correction of all types of experimental biases in quantitative DNA methylation data derived by different technologies. International Journal of Cancer. https://doi.org/10.1002/ijc.33681
Kühnemundt, J., Leifeld, H., Scherg, F., Schmitt, M., Nelke, L.C., Schmitt, T.,... Nietzer, S.L. (2021). Modular micro-physiological human tumor/tissue models based on decellularized tissue for improved preclinical testing. Alternatives To Animal Experimentation , 38(2), 289-306. https://doi.org/10.14573/altex.2008141
Lambarki, M., Kern, J., Croft, D., Engels, C., Deppenwiese, N., Kerscher, A.,... Lablans, M. (2021). Oncology on FHIR: A Data Model for Distributed Cancer Research. In Rainer Röhrig, Tim Beißbarth, Werner Brannath, Hans-Ulrich Prokosch, Irene Schmidtmann, Susanne Stolpe, Antonia Zapf (Eds.), German Medical Data Sciences: Bringing Data to Life. (pp. 203-210). IOS Press.
Le, T.T., Gutierrez-Sacristan, A., Son, J., Hong, C., South, A.M., Beaulieu-Jones, B.K.,... Xia, Z. (2021). Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-99481-9
Leb, I., Magnin, S., Prokosch, H.-U., & Boeker, M. (2021). Patient portals: Objectives, acceptance, and effects on health outcome - A scoping review of reviews. In Rainer Rohrig, Tim Beissbarth, Jochem Konig, Claudia Ose, Geraldine Rauch, Ulrich Sax, Bjorn Schreiweis, Martin Sedlmayr (Eds.), Studies in Health Technology and Informatics (pp. 194-201). Online, DE: IOS Press BV.
Maier, C., Kapsner, L., Mate, S., Prokosch, H.-U., & Kraus, S. (2021). Patient Cohort Identification on Time Series Data Using the OMOP Common Data Model. Applied Clinical Informatics, 12(1), 57-64. https://doi.org/10.1055/s-0040-1721481
Mate, S., Seuchter, S.A., Ehrenberg, K., Deppenwiese, N., Zierk, J., Prokosch, H.-U.,... Kapsner, L. (2021). A Multi-User Terminology Mapping Toolbox. In Rainer Röhrig, Tim Beißbarth, Werner Brannath, Hans-Ulrich Prokosch, Irene Schmidtmann, Susanne Stolpe, Antonia Zapf (Eds.), German Medical Data Sciences: Bringing Data to Life. (pp. 217-223). IOS Press.
Melzer, G., Maiwald, T., Prokosch, H.-U., & Ganslandt, T. (2021). Leveraging Real-World Data for the Selection of Relevant Eligibility Criteria for the Implementation of Electronic Recruitment Support in Clinical Trials. Applied Clinical Informatics, 12(1), 17-26. https://doi.org/10.1055/s-0040-1721010
Moosmann, J., Krusemark, A., Dittrich, S., Ammer, T., Rauh, M., Wölfle, J.,... Zierk, J. (2021). Age- and sex-specific pediatric reference intervals for neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio. International Journal of Laboratory Hematology. https://doi.org/10.1111/ijlh.13768
März, J., Kurlbaum, M., Roche-Lancaster, O., Deutschbein, T., Peitzsch, M., Prehn, C.,... Kroiss, M. (2021). Plasma Metabolome Profiling for the Diagnosis of Catecholamine Producing Tumors. Frontiers in Endocrinology, 12. https://doi.org/10.3389/fendo.2021.722656
Neher, S., Kapsner, L., Prokosch, H.-U., & Toddenroth, D. (2021). Design of an interactive web application for teaching uncertainty interpretations of clinical tests. In Rainer Rohrig, Tim Beissbarth, Jochem Konig, Claudia Ose, Geraldine Rauch, Ulrich Sax, Bjorn Schreiweis, Martin Sedlmayr (Eds.), Studies in Health Technology and Informatics (pp. 156-162). Online, DE: IOS Press BV.
Rai, B., Debus, A., Liang Chunguang, ., Kunz, M., Rauh, M., Bogdan, C., & Schleicher, U. (2021). Arginase 1 of myeloid cells accounts for disease chronicity in Leishmania mexicana-infected mice. In EUROPEAN JOURNAL OF IMMUNOLOGY (pp. 334-334). HOBOKEN: WILEY.
Reichold, M., Dietzel, N., Chmelirsch, C., Kolominsky-Rabas, P., Grässel, E., & Prokosch, H.-U. (2021). Designing and Implementing an IT Architecture for a Digital Multicenter Dementia Registry: DigiDEM Bayern. Applied Clinical Informatics, 12(3), 551-563. https://doi.org/10.1055/s-0041-1731286
Reichold, M., Heß, M., Kolominsky-Rabas, P., Grässel, E., & Prokosch, H.-U. (2021). Usability evaluation of an offline electronic data capture app in a prospective multicenter dementia registry (digidem bayern): Mixed method study. JMIR Formative Research, 5(11). https://doi.org/10.2196/31649
Reichold, M., Selau, M., Grässel, E., Kolominsky-Rabas, P., & Prokosch, H.-U. (2021). EHealth Interventions for Dementia Using WordPress Plugins as a Flexible Dissemination for Dementia Service Providers. In Dieter Hayn, Gunter Schreier, Martin Baumgartner (Eds.), Studies in Health Technology and Informatics (pp. 1-9). Virtual, Online, AUT: IOS Press BV.
Reimer, N., Unberath, P., Busch, H., Börries, M., Metzger, P., Ustjanzew, A.,... Christoph, J. (2021). Challenges and Experiences Extending the cBioPortal for Cancer Genomics to a Molecular Tumor Board Platform. Studies in health technology and informatics, 287, 139-143. https://doi.org/10.3233/SHTI210833
Reimer, N., Unberath, P., Busch, H., & Ingenerf, J. (2021). FhirSpark - Implementing a Mediation Layer to Bring FHIR to the cBioPortal for Cancer Genomics. In John Mantas, Lăcrămioara Stoicu-Tivadar, Catherine Chronaki, Arie Hasman, Patrick Weber, Parisis Gallos, Mihaela Crişan-Vida, Emmanouil Zoulias, Oana Sorina Chirila (Eds.), Public Health and Informatics. (pp. 303-307). IOS Press.
Röhrig, R., Beißbarth, T., Brannath, W., Prokosch, H.-U., Schmidtmann, I., Stolpe, S., & Zapf, A. (Eds.) (2021). German medical data sciences: Bringing data to life: Proceedings of the joint annual meeting of the German association of medical informatics, biometry and epidemiology (GMDS e.V.) and the Central European Network - International Biometric Society (CEN-IBS) 2020 in Berlin, Germany. IOS Press.
Schaaf, J., Sedlmayr, M., Sedlmayr, B., Prokosch, H.-U., & Storf, H. (2021). Evaluation of a clinical decision support system for rare diseases: a qualitative study. BMC Medical Informatics and Decision Making, 21(1). https://doi.org/10.1186/s12911-021-01435-8
Schnell, A., Schwarz, B., Wahlbuhl, M., Allabauer, I., Hess, M., Weber, S.,... Hörning, A. (2021). Distribution and Cytokine Profile of Peripheral B Cell Subsets Is Perturbed in Pediatric IBD and Partially Restored during a Successful IFX Therapy. Inflammatory Bowel Diseases, 27(2), 224-235. https://doi.org/10.1093/ibd/izaa054
Schüttler, C., Münster, T., Gall, C., Trollmann, R., & Schüttler, J. (2021). General Anesthesia in the First 36 Months of Life. Deutsches Ärzteblatt international, 118(49), 835-841. https://doi.org/10.3238/arztebl.m2021.0355
Schüttler, C., Prokosch, H.-U., Hummel, M., Lablans, M., Kroll, B., & Engels, C. (2021). The journey to establishing an IT-infrastructure within the German Biobank Alliance. PLoS ONE, 16(9 September). https://doi.org/10.1371/journal.pone.0257632
Schüttler, C., Prokosch, H.-U., Sedlmayr, M., & Sedlmayr, B. (2021). Erratum: Evaluation of three feasibility tools for identifying patient data and biospecimen availability: Comparative usability study (JMIR Medical Informatics (2021) 9:7 (e25531) DOI: 10.2196/25531). JMIR Medical Informatics, 9(10). https://doi.org/10.2196/33105
Schüttler, C., Prokosch, H.-U., Sedlmayr, M., & Sedlmayr, B. (2021). Evaluation of three feasibility tools for identifying patient data and biospecimen availability: Comparative usability study. JMIR Medical Informatics, 9(7). https://doi.org/10.2196/25531
Schüttler, J., Mang, J.M., Kapsner, L., Seuchter, S.A., Binder, H., Zöller, D.,... Prokosch, H.-U. (2021). Studies on COVID-19 lethality: Causes and dynamics at German University Hospitals Letalität von Patienten mit COVID-19: Untersuchungen zu Ursachen und Dynamik an deutschen Universitätsklinika. Anästhesiologie & Intensivmedizin, 62(6), 244-257. https://doi.org/10.19224/ai2021.244
Sedlmayr, M., Schaaf, J., Sedlmayr, M., Prokosch, H.-U., Tegtbauer, N., Kadioglu, D.,... Storf, H. (2021). Visualization of Similar Patients in a Clinical Decision Support System for Rare Diseases - A Focus Group Study. In Rainer Röhrig, Tim Beißbarth, Werner Brannath, Hans-Ulrich Prokosch, Irene Schmidtmann, Susanne Stolpe, Antonia Zapf (Eds.), German Medical Data Sciences: Bringing Data to Life. (pp. 49-57). IOS Press.
Simons, G., Veldwijk, J., Di Santostefano, R., Englbrecht, M., Radawski, C., Valor, L.,... Falahee, M. (2021). PREFERENCES FOR TREATMENTS TO PREVENT RHEUMATOID ARTHRITIS: DISCRETE CHOICE SURVEY OF GENERAL POPULATIONS IN UNITED KINGDOM, GERMANY, AND ROMANIA. Annals of the Rheumatic Diseases, 96-97. https://dx.doi.org/10.1136/annrheumdis-2021-eular.2168
Sonnenschein, K., Stojanovic, S.D., Dickel, N., Fiedler, J., Bauersachs, J., Thum, T.,... Tongers, J. (2021). Artificial Intelligence Identifies an Urgent Need for Peripheral Vascular Intervention by Multiplexing Standard Clinical Parameters. Biomedicines, 9(10). https://doi.org/10.3390/biomedicines9101456
Stojanović, S.D., Fuchs, M., Liang, C., Schmidt, K., Xiao, K., Just, A.,... Kunz, M. (2021). Reconstruction of the miR-506-Quaking axis in Idiopathic Pulmonary Fibrosis using integrative multi-source bioinformatics. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-89531-7
Stoll, A., Bruns, H., Fuchs, M., Nimmerjahn, F., Kunz, M., Peipp, M.,... Völkl, S. (2021). CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity. Leukemia. https://doi.org/10.1038/s41375-021-01287-1
Stoll, A., Bruns, H., Gamali, S., Saul, D., Fuchs, M., Nimmerjahn, F.,... Mougiakakos, D. (2021). CD137 (4-1BB) triggering leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity. In ONCOLOGY RESEARCH AND TREATMENT (pp. 115-116). BASEL: KARGER.
Stürzl, M., Kunz, M., Krug, S.M., & Naschberger, E. (2021). Angiocrine Regulation of Epithelial Barrier Integrity in Inflammatory Bowel Disease. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.643607
Ustjanzew, A., Desuki, A., Ritzel, C., Dolezilek, A.C., Wagner, D.-C., Christoph, J.,... Paret, C. (2021). cbpManager: a web application to streamline the integration of clinical and genomic data in cBioPortal to support the Molecular Tumor Board. BMC Medical Informatics and Decision Making, 21(1). https://doi.org/10.1186/s12911-021-01719-z
Von Heydebrand, F., Fuchs, M., Kunz, M., Kremer, A., Oostendorp, R.A.J., Wilke, J.,... Völkl, S. (2021). Protein kinase C-β-dependent changes in the glucose metabolism of bone marrow stromal cells of chronic lymphocytic leukemia. Stem Cells. https://doi.org/10.1002/stem.3352
Walther, T., Farin, E., Boeker, M., Prokosch, H.-U., Binder, H., Praus, F.,... Schoenthaler, M. (2021). RECUR - Establishment of An Automated Digital Registry for Patients with Recurrent Stones in the Upper Urinary Tract. Gesundheitswesen, 83, S27-S32. https://doi.org/10.1055/a-1651-0311
Zahn, J., Eberl, S., Rödle, W., Rascher, W., Neubert, A., & Toni, I. (2021). Metamizole Use in Children: Analysis of Drug Utilisation and Adverse Drug Reactions at a German University Hospital between 2015 and 2020. Paediatric Drugs. https://doi.org/10.1007/s40272-021-00481-z
Zahn, J., Wimmer, S., Rödle, W., Toni, I., Sedlmayr, B., Prokosch, H.-U.,... Neubert, A. (2021). Development and Evaluation of a Web-Based Paediatric Drug Information System for Germany. Pharmacy, 9(1). https://doi.org/10.3390/pharmacy9010008
Zierk, J., Baum, H., Bertram, A., Boeker, M., Buchwald, A., Cario, H.,... Rauh, M. (2021). High-resolution pediatric reference intervals for 15 biochemical analytes described using fractional polynomials. Clinical Chemistry and Laboratory Medicine. https://doi.org/10.1515/cclm-2020-1371
Zimmermann, R., Becker, A., Hackstein, H., & Ganslandt, T. (2021). Generation of Reliable Red Cell Concentrate Requirement Lists for Operations and Interventions from Data Warehouse Data and Patient-Related Batch Documentation of Blood Components. Transfusionsmedizin, 11(01), 33-37. https://doi.org/10.1055/a-1256-4465

2020

Baur, F., Nietzer, S.L., Kunz, M., Saal, F., Jeromin, J., Matschos, S.,... Dandekar, G. (2020). Connecting cancer pathways to tumor engines: A stratification tool for colorectal cancer combining human in vitro tissue models with boolean in silico models. Cancers, 12(1). https://doi.org/10.3390/cancers12010028
Becker, L., Ganslandt, T., Prokosch, H.-U., & Newe, A. (2020). Applied Practice and Possible Leverage Points for Information Technology Support for Patient Screening in Clinical Trials: Qualitative Study. JMIR Medical Informatics, 8(6), 1 - 14. https://doi.org/10.2196/15749
Brat, G.A., Weber, G.M., Gehlenborg, N., Avillach, P., Palmer, N.P., Chiovato, L.,... Kohane, I.S. (2020). International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium. npj Digital Medicine, 3(1). https://doi.org/10.1038/s41746-020-00308-0
Buechner, P., Hinderer, M., Unberath, P., Metzger, P., Boeker, M., Acker, T.,... Christoph, J. (2020). Requirements analysis and specification for a molecular tumor board platform based on CBIoPortal. Diagnostics, 10(2). https://doi.org/10.3390/diagnostics10020093
Eismann, H., Schild, S., Neuhaus, C., Baus, J., Happel, O., Heller, A.R.,... St. Pierre, M. (2020). Cognitive aids for crisis management in anaesthesiology. Principles and applications. Anästhesiologie & Intensivmedizin, 61, 239-247. https://doi.org/10.19224/ai2020.239
Eklund, N., Andrianarisoa, N.H., Van Enckevort, E., Anton, G., Debucquoy, A., Mueller, H.,... Silander, K. (2020). Extending the Minimum Information About BIobank Data Sharing Terminology to Describe Samples, Sample Donors, and Events. Biopreservation and biobanking. https://doi.org/10.1089/bio.2019.0129
Ellmann, S., Schlicht, M., Dietzel, M., Janka, R.M., Hammon, M., Saake, M.,... Bäuerle, T. (2020). Computer-aided diagnosis in multiparametric mri of the prostate: An open-access online tool for lesion classification with high accuracy. Cancers, 12(9), 1-15. https://doi.org/10.3390/cancers12092366
Erb, T., Mihai, S., Cipa, F., Herbst, L., Strauss, R., Castellanos, I.,... Held, J. (2020). (1 -> 3)-beta-D-glucan and mannan guided early termination of antifungal therapy in ICU patients: a prospective randomized intervention study (REDUCE-AM). In MYCOSES (pp. 18-18). HOBOKEN: WILEY.
Fuchs, M., Kreutzer, F.P., Kapsner, L., Mitzka, S., Just, A., Perbellini, F.,... Kunz, M. (2020). Integrative bioinformatic analyses of global transcriptome data decipher novel molecular insights into cardiac anti-fibrotic therapies. International Journal of Molecular Sciences, 21(13), 1-11. https://doi.org/10.3390/ijms21134727
Griebel, L., Hinderer, M., Amr, A., Meder, B., Schweig, M., Deuber, D.,... Prokosch, H.-U. (2020). The Patient as Genomic Data Manager - Evaluation of the PROMISE App. In Louise B. Pape-Haugaard, Christian Lovis, Inge Cort Madsen, Patrick Weber, Per Hostrup Nielsen, Philip Scott (Eds.), Digital Personalized Health and Medicine. (pp. 1061-1065). Amsterdam, Berlin, Washington: IOS Press.
Gründner, J., Wolf, N., Tögel, L., Haller, F., Prokosch, H.-U., & Christoph, J. (2020). Integrating Genomics and Clinical Data for Statistical Analysis by Using GEnome MINIng (GEMINI) and Fast Healthcare Interoperability Resources (FHIR): System Design and Implementation. Journal of Medical Internet Research, 22(10). https://doi.org/10.2196/19879
Kann, S., Kunz, M., Hansen, J., Sievertsen, J., Crespo, J.J., Loperena, A.,... Dandekar, T. (2020). Chagas Disease: Detection of Trypanosoma cruzi by a New, High-Specific Real Time PCR. Journal of Clinical Medicine, 9(5). https://doi.org/10.3390/jcm9051517
Kraus, S., Toddenroth, D., Staudigel, M., Rödle, W., Unberath, P., Griebel, L.,... Mate, S. (2020). Mapping the Entire Record-An Alternative Approach to Data Access from Medical Logic Modules. Applied Clinical Informatics, 11(2), 342-349. https://doi.org/10.1055/s-0040-1709708
Neuhaus, C., Schild, S., Eismann, H., Baus, J., Happel, O., Heller, A.R.,... St. Pierre, M. (2020). Funktionalität und Bedienung von eGENA, der elektronischen Gedächtnis- und Entscheidungshilfe für Notfälle in der Anästhesiologie. Anästhesiologie & Intensivmedizin, 61(7-8), 340-351. https://doi.org/10.19224/ai2020.340
Ploner, N., & Prokosch, H.-U. (2020). Integrating a Secure and Generic Mobile App for Patient Reported Outcome Acquisition into an EHR Infrastructure Based on FHIR Resources. In Louise B. Pape-Haugaard, Christian Lovis, Inge Cort Madsen, Patrick Weber, Per Hostrup Nielsen, Philip Scott (Eds.), Digital Personalized Health and Medicine. (pp. 991-995). Amsterdam, Berlin, Washington: IOS Press.
Pugliese, P., Knell, C., & Christoph, J. (2020). Exchange of Clinical and Omics Data According to FAIR Principles: A Review of Open Source Solutions. Methods of Information in Medicine, 59(S 01), e13-e20. https://doi.org/10.1055/s-0040-1712968
Rau, H., Geidel, L., Bialke, M., Blumentritt, A., Langanke, M., Liedtke, W.,... Hoffmann, W. (2020). The generic Informed Consent Service gICS®: implementation and benefits of a modular consent software tool to master the challenge of electronic consent management in research. Journal of Translational Medicine, 18(1), 287-. https://doi.org/10.1186/s12967-020-02457-y
Reichold, M., Dietzel, N., Karrer, L., Grässel, E., Kolominsky-Rabas, P., & Prokosch, H.-U. (2020). Stakeholder perspectives on the key components of a digital service platform supporting dementia - Digidem Bayern. In Gunter Schreier, Dieter Hayn, Alphons Eggerth (Eds.), Studies in Health Technology and Informatics (pp. 224-231). IOS Press BV.
Reinecke, I., Gulden, C., Kümmel, M., Nassirian, A., Blasini, R., & Sedlmayr, M. (2020). Design for a Modular Clinical Trial Recruitment Support System Based on FHIR and OMOP. In Louise B. Pape-Haugaard, Christian Lovis, Inge Cort Madsen, Patrick Weber, Per Hostrup Nielsen, Philip Scott (Eds.), Digital Personalized Health and Medicine. (pp. 158-162). Amsterdam, Berlin, Washington: IOS Press.
Rödle, W., Caliskan, D., Prokosch, H.-U., & Kraus, S. (2020). Evaluation of Different Learning Algorithms of Neural Networks for Drug Dosing Recommendations in Pediatrics. In Günter Schreier, Dieter Hayn, Alphons Eggerth (Eds.), dHealth 2020 – Biomedical Informatics for Health and Care. (pp. 271-276). IOS Press.
Schaaf, J., Prokosch, H.-U., Boeker, M., Schaefer, J., Vasseur, J., Storf, H., & Sedlmayr, M. (2020). Interviews with experts in rare diseases for the development of clinical decision support system software - a qualitative study. BMC Medical Informatics and Decision Making, 20(1), 230-. https://doi.org/10.1186/s12911-020-01254-3
Schaaf, J., Sedlmayr, M., Prokosch, H.-U., Ganslandt, T., Schade-Brittinger, C., von Wagner, M.,... Storf, H. (2020). The Status Quo of Rare Diseases Centres for the Development of a Clinical Decision Support System - A Cross-Sectional Study. In Günter Schreier, Dieter Hayn, Alphons Eggerth (Eds.), dHealth 2020 – Biomedical Informatics for Health and Care. (pp. 176-183).
Schild, S., Gründner, J., Gulden, C., Prokosch, H.-U., St. Pierre, M., & Sedlmayr, M. (2020). Data Model Requirements for a Digital Cognitive Aid for Anesthesia to Support Intraoperative Crisis Management. Applied Clinical Informatics, 11(1), 190-199. https://doi.org/10.1055/s-0040-1703015
Schüttler, C., Huth, V., von Jagwitz-Biegnitz, M., Lablans, M., Prokosch, H.-U., & Griebel, L. (2020). A Federated Online Search Tool for Biospecimens (Sample Locator): Usability Study. Journal of Medical Internet Research, 22(8), e17739-. https://doi.org/10.2196/17739
Stojanović, S.D., Fuchs, M., Fiedler, J., Xiao, K., Meinecke, A., Just, A.,... Kunz, M. (2020). Comprehensive bioinformatics identifies key microrNA players in ATG7-deficient lung fibroblasts. International Journal of Molecular Sciences, 21(11), 1-13. https://doi.org/10.3390/ijms21114126
Stojanović, S.D., Fuchs, M., Kunz, M., Xiao, K., Just, A., Pich, A.,... Thum, T. (2020). Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells. Frontiers in Physiology, 11. https://doi.org/10.3389/fphys.2020.00520
Unberath, P., Prokosch, H.-U., Gründner, J., Erpenbeck, M., Maier, C., & Christoph, J. (2020). EHR-Independent Predictive Decision Support Architecture Based on OMOP. Applied Clinical Informatics, 11(3), 399-404. https://doi.org/10.1055/s-0040-1710393
Zierk, J., Arzideh, F., Kapsner, L., Prokosch, H.-U., Metzler, M., & Rauh, M. (2020). Reference Interval Estimation from Mixed Distributions using Truncation Points and the Kolmogorov-Smirnov Distance (kosmic). Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-58749-2

Related Research Fields

Digital Health

Research topics

Current projects

Center for AI in Medicine

INTERPOLAR: WP3 - Interventionelle Studie: Universitätsklinikum Erlangen

Erschließung des transformativen Anwendungspotentials von TEAM-X in der palliativen Versorgung

Recent publications

2024

2023

2022

2021

2020

Related Research Fields

Contact: