Research projects
DFG-Project: MicroRNA mediated regulation of key components of the Mediator Complex (MED) and its functional role in CRPC EU-EIT Health Project (PI Karolinska Institute)
Imaging in prostate cancer diagnosis BMBF (PI Prof. Bauer/Dermatology)
Diagnostics with biomarker patterns from plasma extra-cellular vesicles (pEV) using artificial intelligence (AI) methods
Identification of biomarkers in urologic cancers for diagnosis, prognosis or therapieprediction/monitoring.
Characterization of (cancer) stem cell-associated gene-/protein expression.
Focus on microRNA-expression profiles in tumors and liquid biopsies.
Recent publications
2024
Angeloni, M., van Doeveren, T., Lindner, S., Volland, P., Schmelmer, J., Foersch, S.,... Bahlinger, V. (2024). A deep-learning workflow to predict upper tract urothelial carcinoma protein-based subtypes from H&E slides supporting the prioritization of patients for molecular testing . Journal of Pathology: Clinical Research , 10 (2). https://doi.org/10.1002/2056-4538.12369
Bahlinger, V., Branz, A., Strissel, P., Strick, R., Lange, F., Geppert, C.-I.,... Eckstein, M. (2024). Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts . Histopathology . https://doi.org/10.1111/his.15130
Eckstein, M., Matek, C., Wagner, P., Erber, R., Büttner-Herold, M., Wild, P.J.,... Bertz, S. (2024). Proposal for a Novel Histological Scoring System as a Potential Grading Approach for Muscle-invasive Urothelial Bladder Cancer Correlating with Disease Aggressiveness and Patient Outcomes. European Urology Oncology , 7 (1), 128-138. https://doi.org/10.1016/j.euo.2023.07.011
Guzman, J., Weigelt, K., Neumann, A.-D., Tripal, P., Schmid, B., Winter, Z.,... Wach, S. (2024). NanoLuc Binary Technology as a methodological approach: an important new tool for studying the localization of androgen receptor and androgen receptor splice variant V7 homo and heterodimers . BMC Cancer , 24 (1). https://doi.org/10.1186/s12885-024-12110-2
Hase, N., Misiak, D., Taubert, H., Hüttelmaier, S., Gekle, M., & Köhn, M. (2024). APOBEC3C-mediated NF-κB activation enhances clear cell renal cell carcinoma progression . Molecular Oncology . https://doi.org/10.1002/1878-0261.13721
Lange, F., Geppert, C.-I., Bahlinger, V., Bertz, S., Stöhr, R., Sikic, D.,... Eckstein, M. (2024). Digital volumetric assessment of CIS and tumor mass compliments conventional histopathological assessment in muscle-invasive urothelial bladder cancer . Virchows Archiv . https://doi.org/10.1007/s00428-024-03875-9
Marcou, M., Galiano, M., Tzschoppe, A., Sauerstein, K., Wach, S., Taubert, H.,... Apel, H. (2024). Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation . Journal of Clinical Medicine , 13 (1). https://doi.org/10.3390/jcm13010033
Smolka, C., Eckstein, M., Jung, R., Lieb, V., Sikic, D., Stöhr, R.,... Wach, S. (2024). Prognostic and Predictive Potential of CCL5 Expression in Muscle-Invasive Bladder Cancer Patients . International Journal of Molecular Sciences , 25 (12). https://doi.org/10.3390/ijms25126325
2023
Eckstein, M., Matek, C., Wagner, P., Erber, R., Büttner-Herold, M., Wild, P.J.,... Bertz, S. (2023). Corrigendum to "Proposal for a Novel Histological Scoring System as a Potential Grading Approach for Muscle-invasive Urothelial Bladder Cancer Correlating with Disease Aggressiveness and Patient Outcomes" [European Urology Oncology (2023)]. European Urology Oncology , 6 (6). https://doi.org/10.1016/j.euo.2023.09.023
Marcou, M., Galiano, M., Tzschoppe, A., Sauerstein, K., Wach, S., Taubert, H.,... Apel, H. (2023). Risk Factor Analysis for Long-Term Graft Survival Following Pediatric Kidney Transplantation: The Importance of Pretransplantation Time on Dialysis and Donor/Recipient Age Difference . Journal of Clinical Medicine , 12 (22). https://doi.org/10.3390/jcm12227014
Wullich, B., Taubert, H., Goebell, P., Kuwert, T., Beck, M., Schott, C.,... Wach, S. (2023). Individualisierte Präzisionsmedizin . Die Urologie . https://doi.org/10.1007/s00120-023-02151-z
2022
Erlmeier, F., Klümper, N., Landgraf, L., Strissel, P., Strick, R., Sikic, D.,... Eckstein, M. (2022). Spatial Immunephenotypes of Distant Metastases but not Matched Primary Urothelial Carcinomas Predict Response to Immune Checkpoint Inhibition . European Urology . https://doi.org/10.1016/j.eururo.2022.10.020
Fichte, A., Neumann, A.-D., Weigelt, K., Guzman, J., Jansen, T., Keinert, J.,... Lieb, V. (2022). Combined miR-486 and GP88 (Progranulin) Serum Levels Are Suggested as Supportive Biomarkers for Therapy Decision in Elderly Prostate Cancer Patients . Life , 12 (5). https://doi.org/10.3390/life12050732
Fiebig, C., Kahlmeyer, A., Bannert, H., Taubert, H., Wach, S., Koneval, L.,... Wullich, B. (2022). Multicentric validation of a comprehensive geriatric assessment to predict functional outcome and mortality following urooncological operations . In ONCOLOGY RESEARCH AND TREATMENT (pp. 111-111). BASEL: KARGER.
Jasinski-Bergner, S., Eckstein, M., Taubert, H., Wach, S., Fiebig, C., Strick, R.,... Seliger, B. (2022). The Human Leukocyte Antigen G as an Immune Escape Mechanism and Novel Therapeutic Target in Urological Tumors . Frontiers in Immunology , 13 , 811200-. https://doi.org/10.3389/fimmu.2022.811200
Lieb, V., Abdulrahman, A., Weigelt, K., Hauch, S., Gombert, M., Guzman, J.,... Wach, S. (2022). Cell-Free DNA Sequencing Reveals Gene Variants in DNA Damage Repair Genes Associated with Prognosis of Prostate Cancer Patients . Cells , 11 (22). https://doi.org/10.3390/cells11223618
Marquardt, A., Richterstetter, M., Taubert, H., Hartmann, A., Wullich, B., Lieb, V.,... Apel, H. (2022). Reduced Recurrence Rates Are Associated with Photodynamic Diagnostics Compared to White Light after Extended Transurethral Resection of Bladder Tumors . Life , 12 (5). https://doi.org/10.3390/life12050641
Sailer, V., von Amsberg, G., Duensing, S., Kirfel, J., Lieb, V., Metzger, E.,... Aigner, A. (2022). Experimental in vitro, ex vivo and in vivo models in prostate cancer research . NAT REV UROL . https://doi.org/10.1038/s41585-022-00677-z
2021
Eckstein, M., Lieb, V., Jung, R., Sikic, D., Weigelt, K., Stöhr, R.,... Wach, S. (2021). Combination of GP88 Expression in Tumor Cells and Tumor-Infiltrating Immune Cells Is an Independent Prognostic Factor for Bladder Cancer Patients . Cells , 10 (7). https://doi.org/10.3390/cells10071796
Greither, T., Steiner, T., Bache, M., Serrero, G., Otto, S., Taubert, H.,... Kappler, M. (2021). Gp88/pgrn serum levels are associated with prognosis for oral squamous cell carcinoma patients . Biology , 10 (5). https://doi.org/10.3390/biology10050400
Keck, B., Borkowetz, A., Pöllmann, J., Jansen, T., Fischer, M., Fuessel, S.,... Wach, S. (2021). Serum miRNAs Support the Indication for MRI-Ultrasound Fusion-Guided Biopsy of the Prostate in Patients with Low-PI-RADS Lesions . Cells , 10 (6). https://doi.org/10.3390/cells10061315
Kullmann, F., Strissel, P., Strick, R., Stöhr, R., Eckstein, M., Bertz, S.,... Weyerer, V. (2021). Frequency of microsatellite instability (MSI) in upper tract urothelial carcinoma: comparison of the Bethesda panel and the Idylla MSI assay in a consecutively collected, multi-institutional cohort . Journal of Clinical Pathology . https://doi.org/10.1136/jclinpath-2021-207855
Lieb, V., Bellut, L., Abdulrahman, A., Weigelt, K., Hauch, S., Gombert, M.,... Wach, S. (2021). Cell-free dna variant sequencing using plasma and ar-v7 testing of circulating tumor cells in prostate cancer patients . Cells , 10 (11). https://doi.org/10.3390/cells10113223
Offermann, A., Kang, D., Watermann, C., Weingart, A., Hupe, M.C., Saraji, A.,... Perner, S. (2021). Analysis of tripartite motif (TRIM) family gene expression in prostate cancer bone metastases . Carcinogenesis , 42 (12), 1475-1484. https://doi.org/10.1093/carcin/bgab083
Sikic, D., Eckstein, M., Weyerer, V., Kubon, J., Breyer, J., Roghmann, F.,... Wach, S. (2021). High expression of ERBB2 is an independent risk factor for reduced recurrence-free survival in patients with stage T1 non-muscle-invasive bladder cancer . Urologic Oncology-Seminars and Original Investigations . https://doi.org/10.1016/j.urolonc.2021.06.021
Sikic, D., Taubert, H., Breyer, J., Eckstein, M., Weyerer, V., Keck, B.,... Wach, S. (2021). The Prognostic Value of FGFR3 Expression in Patients with T1 Non-Muscle Invasive Bladder Cancer . Cancer Management and Research , 13 , 6567-6578. https://doi.org/10.2147/CMAR.S318893
Sikic, D., Taubert, H., Wirtz, R.M., Breyer, J., Eckstein, M., Weyerer, V.,... Keck, B. (2021). High androgen receptor mrna expression is associated with improved outcome in patients with high-risk non-muscle-invasive bladder cancer . Life , 11 (7). https://doi.org/10.3390/life11070642
Sikic, D., Weyerer, V., Geppert, C.-I., Bertz, S., Lange, F., Taubert, H.,... Eckstein, M. (2021). Utility of stromal tumor infiltrating lymphocyte scoring (sTILs) for risk stratification of patients with muscle-invasive urothelial bladder cancer after radical cystectomy . Urologic Oncology-Seminars and Original Investigations . https://doi.org/10.1016/j.urolonc.2021.07.025
Taubert, H., & Eckstein, M. (2021). Ist die Expression des GP88-Proteins (Progranulin) ein klinisch relevanter Prognosefaktor für Prostatakarzinompatienten? Journal für Urologie und Urogynäkologie . https://doi.org/10.1007/s41972-021-00129-7
Taubert, H., Eckstein, M., Epple, E., Jung, R., Weigelt, K., Lieb, V.,... Wach, S. (2021). Immune Cell-Associated Protein Expression Helps to Predict Survival in Muscle-Invasive Urothelial Bladder Cancer Patients after Radical Cystectomy and Optional Adjuvant Chemotherapy . Cells , 10 (1). https://doi.org/10.3390/cells10010159
Tully, K.H., Jütte, H., Wirtz, R.M., Jarczyk, J., Santiago-Walker, A., Zengerling, F.,... Eckstein, M. (2021). Prognostic Role of FGFR Alterations and FGFR mRNA Expression in Metastatic Urothelial Cancer Undergoing Checkpoint Inhibitor Therapy . Urology . https://doi.org/10.1016/j.urology.2021.05.055
Weyerer, V., Eckstein, M., Strissel, P., Wullweber, A., Lange, F., Tögel, L.,... Giedl, J. (2021). Tert promoter mutation analysis of whole-organ mapping bladder cancers . Genes , 12 (2), 1-10. https://doi.org/10.3390/genes12020230
Weyerer, V., Strissel, P., Stohr, C., Eckstein, M., Wach, S., Taubert, H.,... Strick, R. (2021). Endogenous Retroviral-K Envelope Is a Novel Tumor Antigen and Prognostic Indicator of Renal Cell Carcinoma . Frontiers in Oncology , 11 . https://doi.org/10.3389/fonc.2021.657187
Weyerer, V., Strissel, P., Strick, R., Sikic, D., Geppert, C.-I., Bertz, S.,... Eckstein, M. (2021). Integration of spatial pd-l1 expression with the tumor immune microenvironment outperforms standard pd-l1 scoring in outcome prediction of urothelial cancer patients . Cancers , 13 (10). https://doi.org/10.3390/cancers13102327
Weyerer, V., Stöhr, R., Bertz, S., Lange, F., Geppert, C.-I., Wach, S.,... Eckstein, M. (2021). Prognostic impact of molecular muscle-invasive bladder cancer subtyping approaches and correlations with variant histology in a population-based mono-institutional cystectomy cohort . World Journal of Urology . https://doi.org/10.1007/s00345-021-03788-1
Wullweber, A., Strick, R., Lange, F., Sikic, D., Taubert, H., Wach, S.,... Eckstein, M. (2021). Bladder tumor subtype commitment occurs in carcinoma in-situ driven by key signaling pathways including ECM remodeling . In EUROPEAN UROLOGY (pp. S640-S640). AMSTERDAM: ELSEVIER.
Wullweber, A., Strick, R., Lange, F., Sikic, D., Taubert, H., Wach, S.,... Eckstein, M. (2021). Bladder Tumor Subtype Commitment Occurs in Carcinoma In Situ Driven by Key Signaling Pathways Including ECM Remodeling . Cancer Research , 81 (6), 1552-1566. https://doi.org/10.1158/0008-5472.CAN-20-2336
2020
Eckstein, M., Epple, E., Jung, R., Weigelt, K., Lieb, V., Sikic, D.,... Wach, S. (2020). CCL2 expression in tumor cells and tumor-infiltrating immune cells shows divergent prognostic potential for bladder cancer patients depending on lymph node stage . Cancers , 12 (5). https://doi.org/10.3390/cancers12051253
Eckstein, M., Strissel, P., Strick, R., Weyerer, V., Wirtz, R., Pfannstiel, C.,... Sikic, D. (2020). Cytotoxic T-cell-related gene expression signature predicts improved survival in muscle-invasive urothelial bladder cancer patients after radical cystectomy and adjuvant chemotherapy . Journal for ImmunoTherapy of Cancer , 8 (1). https://doi.org/10.1136/jitc-2019-000162
Eckstein, M., Strissel, P., Strick, R., Weyerer, V., Wirtz, R.M., Pfannstiel, C.,... Sikic, D. (2020). Immune Cell Gene Expression Signature is Associated with Improved Outcome in Muscle-Invasive Urothelial Bladder Cancer Patients Treated with Radical Cystectomy . In ONCOLOGY RESEARCH AND TREATMENT (pp. 70-70). BASEL: KARGER.
Erber, R., Meyer, J., Taubert, H., Fasching, P., Wach, S., Häberle, L.,... Rübner, M. (2020). Piwi-like 1 and piwi-like 2 expression in breast cancer . Cancers , 12 (10), 1-17. https://doi.org/10.3390/cancers12102742
Friedrich, M., Heimer, N., Stoehr, C., Steven, A., Wach, S., Taubert, H.,... Seliger, B. (2020). CREB1 is affected by the microRNAs miR-22-3p, miR-26a-5p, miR-27a-3p, and miR-221-3p and correlates with adverse clinicopathological features in renal cell carcinoma . Scientific Reports , 10 (1). https://doi.org/10.1038/s41598-020-63403-y
Greither, T., Koser, F., Holzhausen, H.J., Güttler, A., Würl, P., Kappler, M.,... Taubert, H. (2020). Mir-155-5p and mir-203a-3p are prognostic factors in soft tissue sarcoma . Cancers , 12 (8), 1-13. https://doi.org/10.3390/cancers12082254
Kubon, J., Sikic, D., Eckstein, M., Weyerer, V., Stöhr, R., Neumann, A.,... Wach, S. (2020). Analysis of CXCL9, PD1 and PD-L1 mRNA in stage T1 non-muscle invasive bladder cancer and their association with prognosis . Cancers , 12 (10), 1-13. https://doi.org/10.3390/cancers12102794
Kunz, M., Brandl, M., Bhattacharya, A., Nobereit-Siegel, L., Ewe, A., Weirauch, U.,... Aigner, A. (2020). Nanoparticle-complexed antimiRs for inhibiting tumor growth and metastasis in prostate carcinoma and melanoma . Journal of Nanobiotechnology , 18 (1). https://doi.org/10.1186/s12951-020-00728-w
König, P., Eckstein, M., Jung, R., Abdulrahman, A., Guzman, J., Weigelt, K.,... Lieb, V. (2020). Expression of AR-V7 (Androgen receptor variant 7) protein in granular cytoplasmic structures is an independent prognostic factor in prostate cancer patients . Cancers , 12 (9), 1-15. https://doi.org/10.3390/cancers12092639
Simon, A.G., Tolkach, Y., Esser, L.K., Ellinger, J., Stoehr, C., Ritter, M.,... Toma, M.I. (2020). Mitophagy-associated genes PINK1 and PARK2 are independent prognostic markers of survival in papillary renal cell carcinoma and associated with aggressive tumor behavior . Scientific Reports , 10 (1). https://doi.org/10.1038/s41598-020-75258-4
Taubert, H., Abdulrahman, A., Eckstein, M., Jung, R., Guzman, J., Weigelt, K.,... Wach, S. (2020). Progranulin (GP88) is an independent prognostic factor for prostate cancer patients . In CANCER RESEARCH . PHILADELPHIA: AMER ASSOC CANCER RESEARCH.
Wach, S., Taubert, H., Weigelt, K., Hase, N., Köhn, M., Misiak, D.,... Lai, X. (2020). RNA sequencing of collecting duct renal cell carcinoma suggests an interaction between miRNA and target genes and a predominance of deregulated solute carrier genes . Cancers , 12 (1). https://doi.org/10.3390/cancers12010064
Weyerer, V., Lange, F., Wullweber, A., Stöhr, R., Bertz, S., Wach, S.,... Eckstein, M. (2020). Heterogeneity-analysis of molecular subtypes of muscle-invasive bladder cancer and their precursor lesions in multiregion mapped whole-organ bladders . In UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (pp. 907-907). NEW YORK: ELSEVIER SCIENCE INC.
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