Advanced imaging in gastroenterology.
Research projects
- molecular endoscopy optoacoustics near infraved imaging
2024
- Atreya, I., & Neurath, M. (2024). Linking IL-10 signaling with lipid metabolic programs in macrophages: dysregulated ceramide homeostasis drives colitis. Signal Transduction and Targeted Therapy, 9(1). https://doi.org/10.1038/s41392-024-01864-7
- Atreya, R., Kühbacher, T., Waldner, M., Hirschmann, S., Drvarov, O., Abu Hashem, R.,... Neurath, M. (2024). Submucosal Injection of the RNA Oligonucleotide GUT-1 in Active Ulcerative Colitis Patients: A Randomized, Double-Blind, Placebo-Controlled Phase 2a Induction Trial. Journal of Crohns & Colitis, 18(3), 406-415. https://doi.org/10.1093/ecco-jcc/jjad162
- Atreya, R., & Neurath, M. (2024). Biomarkers for Personalizing IBD Therapy: The Quest Continues. Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2024.01.026
- Cuba, L., Dürr, P., Geßner, K., Häcker, B., Fietkau, R., Siebler, J.,... Dörje, F. (2024). A Hybrid Type III Effectiveness-Implementation Trial to Optimize Medication Safety With Oral Antitumor Therapy in Real-World: The AMBORA Competence and Consultation Center. JCO Oncology Practice, 20(9), 1219-1230. https://doi.org/10.1200/OP.23.00694
- Dorner, H., Stolzer, I., Mattner, J., Kaminski, S., Leistl, S., Edrich, L.-M.,... Günther, C. (2024). Gut Pathobiont–Derived Outer Membrane Vesicles Drive Liver Inflammation and Fibrosis in Primary Sclerosing Cholangitis–Associated Inflammatory Bowel Disease. Gastroenterology. https://doi.org/10.1053/j.gastro.2024.06.032
- Erkert, L., Gamez-Belmonte, R., Kabisch, M., Schödel, L., Patankar, J., Gonzalez Acera, M.,... Becker, C. (2024). Alzheimer’s disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis. Gut. https://doi.org/10.1136/gutjnl-2023-331622
- Fagni, F., Tascilar, K., Noversa de Sousa, R., Bayat, S., Sollfrank, L., Kleyer, A.,... Simon, D. (2024). Unveiling Metabolic Similarities of Entheses in Patients with Psoriasis and Psoriatic Arthritis Using Noninvasive In Vivo Molecular Imaging: Results From a Cross-sectional Exploratory Study. Arthritis and Rheumatology, 76(9), 1387-1396. https://doi.org/10.1002/art.42917
- Haug, M., Schwappacher, R., Pollmann, C., Ritter, P., Michael, M., Herrmann, H.J.,... Friedrich, O. (2024). Effects of Adjuvant Exercise and Nutrition Therapy on Muscle Fibre Biomechanics in Gastrointestinal Cancer Patients. Cancers, 16(8). https://doi.org/10.3390/cancers16081608
- Klüppel, M., Adler, W., Schellhaas, B., Jesper, D., Neurath, M., & Pfeifer, L. (2024). Prognostic relevance of ARFI elastography in comparison to liver histology and the FIB-4 score. Ultraschall in der Medizin, 45(3), 316-322. https://doi.org/10.1055/a-2178-4808
- Lehmann, M., Weixler, B., Elezkurtaj, S., Loddenkemper, C., Atreya, I., Atreya, R.,... Zundler, S. (2024). Spatial Single Cell Profiling Using Imaging Mass Cytometry: Inflammatory Versus Penetrating Crohn's Disease. Journal of Crohns & Colitis, 18(8), 1305-1318. https://doi.org/10.1093/ecco-jcc/jjae033
- Lethen, I., Lechner-Grimm, K., Gabel, M., Knauß, A., Atreya, R., Neurath, M., & Weigmann, B. (2024). Tofacitinib Affects M1-like and M2-like Polarization and Tissue Factor Expression in Macrophages of Healthy Donors and IBD Patients. Inflammatory Bowel Diseases, 30(7), 1151-1163. https://doi.org/10.1093/ibd/izad290
- Li, Y., Gröhl, J., Haney, B., Caranovic, M., Lorenz-Meyer, E., Papatheodorou, N.,... Rother, U. (2024). Teachability of multispectral optoacoustic tomography. Journal of Biophotonics. https://doi.org/10.1002/jbio.202400106
- Nedoschill, E., Wagner, A.L., Danko, V., Bühler, A., Raming, R., Jüngert, J.M.,... Regensburger, A. (2024). Monitoring spinal muscular atrophy with three-dimensional optoacoustic imaging. Med, 5(5), 469-478.e3. https://doi.org/10.1016/j.medj.2024.02.010
- Neurath, M. (2024). Strategies for targeting cytokines in inflammatory bowel disease. Nature reviews. Immunology. https://doi.org/10.1038/s41577-024-01008-6
- Neurath, M. (2024). The Proteomic Signature of Tissue Remodeling in Chronic Intestinal Inflammation. Cellular and Molecular Gastroenterology and Hepatology, 17(4), 660-661. https://doi.org/10.1016/j.jcmgh.2024.01.019
- Neurath, M., & Berg, L.J. (2024). VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases. Trends in Immunology, 45(8), 580-596. https://doi.org/10.1016/j.it.2024.06.004
- Neurath, M., Sands, B.E., & Rieder, F. (2024). Cellular immunotherapies and immune cell depleting therapies in inflammatory bowel diseases: the next magic bullet? Gut. https://doi.org/10.1136/gutjnl-2024-332919
- Overbeek, K.A., Poulsen, J.L., Lanzillotta, M., Vinge-Holmquist, O., Macinga, P., Demirci, A.F.,... Gubergrits, N. (2024). Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment. Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2023.12.010
- Pradhan, R., Dieterich, W., Natarajan, A., Schwappacher, R., Reljic, D., Herrmann, H.J.,... Zopf, Y. (2024). Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia. Cancers, 16(10). https://doi.org/10.3390/cancers16101921
- Regensburger, A., Eckstein, M., Wetzl, M., Raming, R., Paulus, L.-P., Bühler, A.,... Knieling, F. (2024). Multispectral optoacoustic tomography enables assessment of disease activity in paediatric inflammatory bowel disease. Photoacoustics, 35. https://doi.org/10.1016/j.pacs.2023.100578
- Reljic, D., Zieseniss, N., Herrmann, H.J., Neurath, M., & Zopf, Y. (2024). Protein Supplementation Increases Adaptations to Low-Volume, Intra-Session Concurrent Training in Untrained Healthy Adults: A Double-Blind, Placebo-Controlled, Randomized Trial. Nutrients, 16(16). https://doi.org/10.3390/nu16162713
- Schramm, S., Liu, L., Saad, M., Dietz, L., Dedden, M., Müller, T.,... Zundler, S. (2024). Blocking GPR15 Counteracts Integrin-dependent T Cell Gut Homing in Vivo. Journal of Crohns & Colitis, 18(7), 1162-1172. https://doi.org/10.1093/ecco-jcc/jjae012
- Schulz-Kuhnt, A., Rühle, K., Javidmehr, A., Döbrönti, M., Biwank, J., Knittel, S.,... Atreya, I. (2024). ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo. Gut, gutjnl-2023-330543. https://doi.org/10.1136/gutjnl-2023-330543
- Sommer, K., Garibagaoglu, H., Paap, E.-M., Wiendl, M., Müller, T., Atreya, I.,... Zundler, S. (2024). Discrepant Phenotyping of Monocytes Based on CX3CR1 and CCR2 Using Fluorescent Reporters and Antibodies. Cells, 13(10). https://doi.org/10.3390/cells13100819
- Suzuki, K., Sameshima, Y., Yokoyama, J., Terai, S., Yoneyama, H., Atreya, R.,... Asakura, H. (2024). Add-on multiple submucosal injections of the RNA oligonucleotide GUT-1 to anti-TNF antibody treatment in patients with moderate-to-severe ulcerative colitis: an open-label, proof-of concept study. Inflammation and Regeneration, 44(1). https://doi.org/10.1186/s41232-024-00332-7
- Thoma, O.-M., Naschberger, E., Kubánková, M., Larafa, I., Kramer, V., Menchicchi, B.,... Waldner, M. (2024). p21 Prevents the Exhaustion of CD4+ T Cells Within the Antitumor Immune Response Against Colorectal Cancer. Gastroenterology, 166(2), 284-297.e11. https://doi.org/10.1053/j.gastro.2023.09.017
- Träger, A.P., Günther, J., Raming, R., Paulus, L.-P., Lang, W., Meyer, A.,... Rother, U. (2024). Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease. Photoacoustics, 35. https://doi.org/10.1016/j.pacs.2023.100579
- Vitali, F., Rath, T., Klenske, E., Vögele, A.-L., Ganzleben, I., Zundler, S.,... Atreya, R. (2024). Long-term outcomes of cyclosporin induction and ustekinumab maintenance combination therapy in patients with steroid-refractory acute severe ulcerative colitis. Therapeutic Advances in Gastroenterology, 17. https://doi.org/10.1177/17562848231218555
- Wiendl, M., Dedden, M., Liu, L., Schweda, A., Paap, E.-M., Ullrich, K.,... Zundler, S. (2024). Etrolizumab-s fails to control E-Cadherin-dependent co-stimulation of highly activated cytotoxic T cells. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45352-6
2023
- Atreya, R., & Neurath, M. (2023). Further efficacy and safety data for maintenance upadacitinib in ulcerative colitis. Lancet Gastroenterology and Hepatology. https://doi.org/10.1016/S2468-1253(23)00271-6
- Atreya, R., & Neurath, M. (2023). The sphingosine-1-phosphate receptor agonist etrasimod in ulcerative colitis. The Lancet. https://doi.org/10.1016/S0140-6736(23)00228-3
- Baronetto, A., Graf, L., Fischer, S., Neurath, M., & Amft, O. (2023). Segment-Based Spotting of Bowel Sounds Using Pretrained Models in Continuous Data Streams. IEEE Journal of Biomedical and Health Informatics, 1-12. https://doi.org/10.1109/JBHI.2023.3269910
- Bühler, A., Brown, E., Paulus, L.-P., Eckstein, M., Thoma, O.-M., Oraiopoulou, M.-E.,... Regensburger, A. (2023). Transrectal Absorber Guide Raster-Scanning Optoacoustic Mesoscopy for Label-Free In Vivo Assessment of Colitis. Advanced Science. https://doi.org/10.1002/advs.202300564
- Chiriac, M.-T., Hracsko, Z., Becker, C., & Neurath, M. (2023). STAT2 Controls Colorectal Tumorigenesis and Resistance to Anti-Cancer Drugs. Cancers, 15(22). https://doi.org/10.3390/cancers15225423
- Chiriac, M.-T., Hracsko, Z., Günther, C., Gonzalez Acera, M., Atreya, R., Stolzer, I.,... Neurath, M. (2023). IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling. Gut. https://doi.org/10.1136/gutjnl-2023-329628
- Danko, V., Jüngert, J.M., Schüssler, S., Bühler, A., Klett, D., Federle, A.,... Wagner, A. (2023). Hybrid reflected-ultrasound computed tomography versus B-mode-ultrasound for muscle scoring in spinal muscular atrophy. Journal of Neuroimaging. https://doi.org/10.1111/jon.13081
- De Boer, N.K., Simsek, M., Meijer, B., Neurath, M., Van Bodegraven, A., & Mulder, C.J. (2023). Drug rediscovery in gastroenterology: From off-label to on-label use of thioguanine in inflammatory bowel disease. Gut. https://doi.org/10.1136/gutjnl-2023-329679
- Dedden, M., Wiendl, M., Müller, T., Neurath, M., & Zundler, S. (2023). Manual cell selection in single cell transcriptomics using scSELpy supports the analysis of immune cell subsets. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1027346
- Günther, J., Knieling, F., Träger, A.P., Lang, W., Meyer, A., Regensburger, A.,... Rother, U. (2023). Targeting Muscular Hemoglobin Content for Classification of Peripheral Arterial Disease by Noninvasive Multispectral Optoacoustic Tomography. Journal of the American College of Cardiology : Cardiovascular imaging, 16(5), 719-721. https://doi.org/10.1016/j.jcmg.2022.11.010
- Hardt, L., Herrmann, H.J., Reljic, D., Jaensch, P., Zerth, J., Neurath, M., & Zopf, Y. (2023). Are Guideline Recommendations on Supportive Nutrition and Exercise Therapy for Cancer Patients Implemented in Clinical Routine? A National Survey with Real-Life Data. Nutrients, 15(14). https://doi.org/10.3390/nu15143172
- Heidbreder, K., Sommer, K., Wiendl, M., Müller, T., Atreya, I., Hildner, K.,... Zundler, S. (2023). Nr4a1-dependent non-classical monocytes are important for macrophage-mediated wound healing in the large intestine. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.1040775
- Jefremow, A., & Neurath, M. (2023). Novel Small Molecules in IBD: Current State and Future Perspectives. Cells, 12(13). https://doi.org/10.3390/cells12131730
- Koop, K., Enderle, K., Hillmann, M., Ruspeckhofer, L., Vieth, M., Sturm, G.,... Neufert, C. (2023). Interleukin 36 receptor-inducible matrix metalloproteinase 13 mediates intestinal fibrosis. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1163198
- Lindemann, A., Roth, D., Koop, K., Neufert, C., Zundler, S., Atreya, R.,... Leppkes, M. (2023). Protective effect of the novel calcineurin inhibitor voclosporin in experimental colitis. Frontiers in Medicine, 10. https://doi.org/10.3389/fmed.2023.1177450
- Matthe, D., Dinkel, M., Schmid, B., Vogler, T., Neurath, M., Poeck, H.,... Hildner, K. (2023). Novel T cell/organoid culture system allows ex vivo modeling of intestinal graft-versus-host disease. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1253514
- Müller, T., Liu, L., Czerwinski, T., Wiesinger, M., Dedden, M., Paap, E.-M.,... Bosch-Voskens, C. (2023). Increased Motility and Suppression of Ex Vivo–Expanded Regulatory T Cells Designed for Adoptive Transfer Therapy in Ulcerative Colitis. Cellular and Molecular Gastroenterology and Hepatology. https://doi.org/10.1016/j.jcmgh.2023.04.002
- Neurath, M., & Vieth, M. (2023). Different levels of healing in inflammatory bowel diseases: mucosal, histological, transmural, barrier and complete healing. Gut. https://doi.org/10.1136/gutjnl-2023-329964
- Paulus, L.-P., Bühler, A., Wagner, A., Raming, R., Jüngert, J., Simon, D.,... Knieling, F. (2023). Contrast-Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract. Advanced Science. https://doi.org/10.1002/advs.202302562
- Paulus, L.-P., Wagner, A., Buehler, A., Raming, R., Jüngert, J., Simon, D.,... Regensburger, A. (2023). Multispectral optoacoustic tomography of the human intestine – temporal precision and the influence of postprandial gastrointestinal blood flow. Photoacoustics, 30. https://doi.org/10.1016/j.pacs.2023.100457
- Pietschner, R., Rath, T., Neurath, M., & Atreya, R. (2023). Current and Emerging Targeted Therapies for Ulcerative Colitis. Visceral Medicine, 39(2), 46-53. https://doi.org/10.1159/000530983
- Rath, T., Atreya, R., Bodenschatz, J., Uter, W., Geppert, C.-I., Vitali, F.,... Neurath, M. (2023). Intestinal Barrier Healing Is Superior to Endoscopic and Histologic Remission for Predicting Major Adverse Outcomes in Inflammatory Bowel Disease: The Prospective ERIca Trial. Gastroenterology, 164(2), 241-255. https://doi.org/10.1053/j.gastro.2022.10.014
- Rath, T., Atreya, R., Bodenschatz, J., Uter, W., Geppert, C.-I., Vitali, F.,... Neurath, M. (2023). Healing of the epithelial barrier in the ileum is superior to endoscopic and histologic remission for predicting major adverse outcomes in ulcerative colitis. Frontiers in Medicine, 10. https://doi.org/10.3389/fmed.2023.1221449
- Rath, T., Atreya, R., & Neurath, M. (2023). A spotlight on intestinal permeability and inflammatory bowel diseases. Expert Review of Gastroenterology and Hepatology, 17(9), 893-902. https://doi.org/10.1080/17474124.2023.2242772
- Reljic, D., Frenk, F., Herrmann, H.J., Neurath, M., & Zopf, Y. (2023). Maximum Heart Rate- and Lactate Threshold-Based Low-Volume High-Intensity Interval Training Prescriptions Provide Similar Health Benefits in Metabolic Syndrome Patients. Healthcare, 11(5). https://doi.org/10.3390/healthcare11050711
- Reljic, D., Koller, A., Herrmann, H.J., Ekici, A.B., Neurath, M., & Zopf, Y. (2023). Differential Effects of Very-Low-Volume Exercise Modalities on Telomere Length, Inflammation, and Cardiometabolic Health in Obese Metabolic Syndrome Patients: A Subanalysis from Two Randomized Controlled Trials. Antioxidants, 12(10). https://doi.org/10.3390/antiox12101847
- Schnell, A., Jüngert, J.M., Klett, D., Hober, H., Kaiser, N., Ruppel, R.,... Regensburger, A. (2023). Increase of liver stiffness and altered bile acid metabolism after triple CFTR modulator initiation in children and young adults with cystic fibrosis. Liver International. https://doi.org/10.1111/liv.15544
- Schulze, L., Becker, E., Dedden, M., Liu, L., Van Passen, C., Mohamed Abdou, M.,... Zundler, S. (2023). Differential Effects of Ontamalimab Versus Vedolizumab on Immune Cell Trafficking in Intestinal Inflammation and Inflammatory Bowel Disease. Journal of Crohns & Colitis, 17(11), 1817-1832. https://doi.org/10.1093/ecco-jcc/jjad088
- Sommer, K., Heidbreder, K., Kreiß, L., Dedden, M., Paap, E.-M., Wiendl, M.,... Zundler, S. (2023). Anti-beta 7 integrin treatment impedes the recruitment on non-classical monocytes to the gut and delays macrophage-mediated intestinal wound healing. Clinical and Translational Medicine, 13(4). https://doi.org/10.1002/ctm2.1233
- Soteriou, D., Kubankova, M., Schweitzer, C., Lopez Posadas, R., Pradhan, R., Thoma, O.-M.,... Guck, J. (2023). Rapid single-cell physical phenotyping of mechanically dissociated tissue biopsies. Nature Biomedical Engineering. https://doi.org/10.1038/s41551-023-01015-3
- Stolzer, I., Scherer, E., Süß, P., Rothhammer, V., Winner, B., Neurath, M., & Günther, C. (2023). Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration. International Journal of Molecular Sciences, 24(19). https://doi.org/10.3390/ijms241914925
- Ullrich, K., Derdau, J., Baltes, C., Battistella, A., Rosso, G., Uderhardt, S.,... Zundler, S. (2023). IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells. Gut, 72(11), 2081-2094. https://doi.org/10.1136/gutjnl-2023-329818
- Verstockt, B., Salas, A., Sands, B.E., Abraham, C., Leibovitzh, H., Neurath, M., & Vande Casteele, N. (2023). IL-12 and IL-23 pathway inhibition in inflammatory bowel disease. Nature Reviews Gastroenterology & Hepatology. https://doi.org/10.1038/s41575-023-00768-1
- Vetter, M., Waldner, M., Zundler, S., Klett, D., Bocklitz, T., Neurath, M.,... Jesper, D. (2023). Artificial intelligence for the classification of focal liver lesions in ultrasound - a systematic review. Ultraschall in der Medizin, 44(4), 395-407. https://doi.org/10.1055/a-2066-9372
- Vitali, F., Zundler, S., Jesper, D., Strobel, D., Wildner, D., De Pretis, N.,... Neurath, M. (2023). Endoscopic Ultrasound in Pancreatology: Focus on Inflammatory Diseases and Interventions. Visceral Medicine. https://doi.org/10.1159/000533433
- Vitali, F., Zundler, S., Jesper, D., Wildner, D., Strobel, D., Frulloni, L., & Neurath, M. (2023). Diagnostic Endoscopic Ultrasound in Pancreatology: Focus on Normal Variants and Pancreatic Masses. Visceral Medicine, 39(5), 121-130. https://doi.org/10.1159/000533432
- Waldner, M., & Neurath, M. (2023). TGFβ and the Tumor Microenvironment in Colorectal Cancer. Cells, 12(8). https://doi.org/10.3390/cells12081139
- Weber, S., Sitte, S., Vögele, A.-L., Sologub, L., Wilfer, A., Rath, T.,... Atreya, R. (2023). NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases. Journal of Crohns & Colitis. https://doi.org/10.1093/ecco-jcc/jjad164
- Wittner, L., Wagener, L., Wiese, J.J., Stolzer, I., Krug, S.M., Naschberger, E.,... Günther, C. (2023). Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing. International Journal of Molecular Sciences, 24(8). https://doi.org/10.3390/ijms24087402
- Zundler, S., Vitali, F., Kharboutli, S., Völkl, S., Polifka, I., Mackensen, A.,... Mougiakakos, D. (2023). Case Report: IBD-like colitis following CAR T cell therapy for diffuse large B cell lymphoma. Frontiers in Oncology, 13. https://doi.org/10.3389/fonc.2023.1149450
2022
- Atreya, I., & Neurath, M. (2022). How the Tumor Micromilieu Modulates the Recruitment and Activation of Colorectal Cancer-Infiltrating Lymphocytes. Biomedicines, 10(11). https://doi.org/10.3390/biomedicines10112940
- Atreya, R., Bojarski, C., Kühl, A.A., Trajanoski, Z., Neurath, M., & Siegmund, B. (2022). Ileal and colonic Crohn's disease: Does location makes a difference in therapy efficacy? Current Research in Pharmacology and Drug Discovery, 3. https://doi.org/10.1016/j.crphar.2022.100097
- Atreya, R., & Neurath, M. (2022). Deciphering Novel Mechanistic and Pharmacokinetic Effects of Tofacitinib in Intestinal Inflammation: Expect the Unexpected. Cellular and Molecular Gastroenterology and Hepatology, 13(2), 672-673. https://doi.org/10.1016/j.jcmgh.2021.10.003
- Atreya, R., & Neurath, M. (2022). IL-23 Blockade in Anti-TNF Refractory IBD: From Mechanisms to Clinical Reality. Journal of Crohns & Colitis, 16(SUPPL 2). https://doi.org/10.1093/ecco-jcc/jjac007
- Atreya, R., & Neurath, M. (2022). Induction of microRNA-124 as a novel therapeutic concept in ulcerative colitis. Lancet Gastroenterology and Hepatology, 7(11), 977-978. https://doi.org/10.1016/S2468-1253(22)00249-7
- Atreya, R., & Neurath, M. (2022). Inflammatory bowel diseases - therapy update 2022 Chronisch-entzündliche Darmerkrankungen. Deutsche Medizinische Wochenschrift, 147(6), 295-300. https://doi.org/10.1055/a-1585-4026
- Becker, E., Schweda, A., Ullrich, K., Voskens, C., Atreya, R., Müller, T.,... Zundler, S. (2022). Limited Dose-Dependent Effects of Vedolizumab on Various Leukocyte Subsets. Clinical and Translational Gastroenterology, 13(6), e00494-. https://doi.org/10.14309/ctg.0000000000000494
- Besendorf, L., Müller, T., Geppert, C.-I., Schneider, I., Mühl, L., Atreya, I.,... Zundler, S. (2022). Vedolizumab blocks alpha 4 beta 7 integrin-mediated T cell adhesion to MAdCAM-1 in microscopic colitis. Therapeutic Advances in Gastroenterology, 15. https://doi.org/10.1177/17562848221098899
- Beyna, T., Moreels, T., Arvanitakis, M., Pioche, M., Saurin, J.-C., May, A.,... Neuhaus, H. (2022). Motorized spiral enteroscopy: Results of an international multicenter prospective observational clinical study in patients with normal and altered gastrointestinal anatomy. Endoscopy. https://doi.org/10.1055/a-1831-6215
- Casadei-Gardini, A., Rimini, M., Kudo, M., Shimose, S., Tada, T., Suda, G.,... Cascinu, S. (2022). Real Life Study of Lenvatinib Therapy for Hepatocellular Carcinoma: RELEVANT Study. Liver Cancer, 11(6), 527-539. https://doi.org/10.1159/000525145
- Denk, D., Petrocelli, V., Conche, C., Drachsler, M., Ziegler, P.K., Braun, A.,... Greten, F.R. (2022). Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity, 55(11), 2059-2073.e8. https://doi.org/10.1016/j.immuni.2022.09.014
- Dieterich, W., Schuster, C., Gundel, P., Scherf, K.A., Pronin, D., Geisslitz, S.,... Zopf, Y. (2022). Proteins from Modern and Ancient Wheat Cultivars: Impact on Immune Cells of Healthy Individuals and Patients with NCGS. Nutrients, 14(20). https://doi.org/10.3390/nu14204257
- Dubinsky, M.C., Magro, F., Steinwurz, F., Hudesman, D.P., Kinnucan, J.A., Ungaro, R.C.,... Regueiro, M. (2022). Association of C-reactive Protein and Partial Mayo Score With Response to Tofacitinib Induction Therapy: Results From the Ulcerative Colitis Clinical Program. Inflammatory Bowel Diseases. https://doi.org/10.1093/ibd/izac061
- Düll, M., Karlen, V., Vetter, M., Dietrich, P., Kupfer, J., Neurath, M., & Kremer, A. (2022). Chronic pruritus represents a major burden in non-cholestatic hepatobiliary disorders. In JOURNAL OF HEPATOLOGY (pp. S163-S163). AMSTERDAM: ELSEVIER.
- Gabel, M., Knauß, A., Fischer, D., Neurath, M., & Weigmann, B. (2022). Surface Design Options in Polymer- and Lipid-Based siRNA Nanoparticles Using Antibodies. International Journal of Molecular Sciences, 23(22). https://doi.org/10.3390/ijms232213929
- Ganzleben, I., Klett, D., Hartz, W., Götzfried, L., Vitali, F., Neurath, M., & Waldner, M. (2022). Multispectral optoacoustic tomography for the non-invasive identification of patients with severe anemia in vivo. Photoacoustics, 28. https://doi.org/10.1016/j.pacs.2022.100414
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- Reljic, D., Dieterich, W., Herrmann, H.J., Neurath, M., & Zopf, Y. (2022). “HIIT the Inflammation”: Comparative Effects of Low-Volume Interval Training and Resistance Exercises on Inflammatory Indices in Obese Metabolic Syndrome Patients Undergoing Caloric Restriction. Nutrients, 14(10). https://doi.org/10.3390/nu14101996
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2021
- Al-Zaher, N., Vitali, F., Neurath, M., & Görtz, R. (2021). The Positive Rate of Pulmonary Embolism by CT Pulmonary Angiography Is High in an Emergency Department, even in Low-Risk or Young Patients. Medical Principles and Practice, 30(1), 37-44. https://doi.org/10.1159/000511464
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- Jefremow, A., & Neurath, M. (2021). New agents for immunosuppression. Best Practice & Research in Clinical Gastroenterology. https://doi.org/10.1016/j.bpg.2021.101763
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- Jesper, D., Fiedler, S., Klett, D., Waldner, M., Schellhaas, B., Zundler, S.,... Pfeifer, L. (2021). Shear Wave Dispersion Imaging for the Characterization of Focal Liver Lesions - A Pilot study. Ultraschall in der Medizin. https://doi.org/10.1055/a-1610-9171
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2020
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- Lechner, K.S., Neurath, M., & Weigmann, B. (2020). Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis. Journal of Molecular Medicine. https://doi.org/10.1007/s00109-020-01958-z
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- Mortier, E., Ma, A., Malynn, B.A., & Neurath, M. (2020). Editorial: Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.608636
- Neufert, C., Heichler, C., Brabletz, T., Scheibe, K., Boonsanay, V., Greten, F.R., & Neurath, M. (2020). Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis. Nature Protocols. https://doi.org/10.1038/s41596-020-00412-1
- Neurath, M. (2020). Covid-19 and immunomodulation in IBD. Gut. https://doi.org/10.1136/gutjnl-2020-321269
- Neurath, M. (2020). IL-36 in chronic inflammation and cancer. Cytokine & Growth Factor Reviews. https://doi.org/10.1016/j.cytogfr.2020.06.006
- Rath, T., Morgenstern, N., Vitali, F., Atreya, R., & Neurath, M. (2020). Advanced Endoscopic Imaging in Colonic Neoplasia. Visceral Medicine. https://doi.org/10.1159/000505411
- Rath, T., Neurath, M., & Atreya, R. (2020). Molecular imaging in inflammatory bowel disease. Elsevier.
- Rath, T., Pfeifer, L., Neufert, C., Kremer, A., Leppkes, M., Hoffman, A.,... Zopf, S. (2020). Retrograde inspection vs standard forward view for the detection of colorectal adenomas during colonoscopy: A back-to-back randomized clinical trial. World Journal of Gastroenterology, 26(16), 1962-1970. https://doi.org/10.3748/wjg.v26.i16.1962
- Reljic, D., Frenk, F., Herrmann, H.J., Neurath, M., & Zopf, Y. (2020). Low-volume high-intensity interval training improves cardiometabolic health, work ability and well-being in severely obese individuals: a randomized-controlled trial sub-study. Journal of Translational Medicine, 18(1). https://doi.org/10.1186/s12967-020-02592-6
- Reljic, D., Konturek, P., Herrmann, H.J., Neurath, M., & Zopf, Y. (2020). Effects of whole-body electromyostimulation exercise and caloric restriction on cardiometabolic risk profile and muscle strength in obese women with the metabolic syndrome: a pilot study. Journal of Physiology and Pharmacology, 71(1). https://doi.org/10.26402/jpp.2020.1.08
- Reljic, D., Zarafat, D., Jensen, B., Herrmann, H.J., Neurath, M., Konturek, P.C., & Zopf, Y. (2020). Phase angle and vector analysis from multifrequency segmental bioelectrical impedance analysis: New reference data for older adults. Journal of Physiology and Pharmacology, 71(4), 1-9. https://doi.org/10.26402/jpp.2020.4.04
- Ruder, B., Günther, C., Stürzl, M., Neurath, M., Cesarman, E., Ballon, G., & Becker, C. (2020). Viral FLIP blocks Caspase-8 driven apoptosis in the gut in vivo. PLoS ONE, 15(1). https://doi.org/10.1371/journal.pone.0228441
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- Schett, G., Sticherling, M., & Neurath, M. (2020). COVID-19: risk for cytokine targeting in chronic inflammatory diseases? Nature Reviews Immunology. https://doi.org/10.1038/s41577-020-0312-7
- Schmitt, H., Ulmschneider, J., Billmeier, U., Scarozza, P., Sonnewald, S., Reid, S.,... Vieth, M. (2020). The TLR9 agonist cobitolimod induces IL10 producing wound healing macrophages and regulatory T cells in ulcerative colitis. Journal of Crohns & Colitis, 14(4), 508-524. https://doi.org/10.1093/ecco-jcc/jjz170
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- Schulz-Kuhnt, A., Wirtz, S., Neurath, M., & Atreya, I. (2020). Regulation of Human Innate Lymphoid Cells in the Context of Mucosal Inflammation. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.01062
- Schwappacher, R., Schink, K., Sologub, S., Dieterich, W., Reljic, D., Friedrich, O.,... Zopf, Y. (2020). Physical activity and advanced cancer: evidence of exercise-sensitive genes regulating prostate cancer cell proliferation and apoptosis. The Journal of Physiology. https://doi.org/10.1113/JP279150
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- Ullrich, K., Schulze, L., Paap, E.-M., Müller, T., Neurath, M., & Zundler, S. (2020). IMMUNOLOGY OF IL-12: AN UPDATE ON FUNCTIONAL ACTIVITIES AND IMPLICATIONS FOR DISEASE. Excli Journal, 19, 1563-1589. https://doi.org/10.17179/excli2020-3104
- Vetter, M., Kremer, A., Agaimy, A., Pfeifer, L., Neurath, M., Zopf, S., & Siebler, J. (2020). How Much Liver Tissue Is Required for Sufficient Histological Staging in Patients with Primary Biliary Cholangitis? Digestion. https://doi.org/10.1159/000507392
- Yu, Y., Zielinska, M., Li, W., Bernkopf, D., Heilingloh, C., Neurath, M., & Becker, C. (2020). PGAM5-MAVS interaction regulates TBK1/ IRF3 dependent antiviral responses. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-65155-1
- Zopf, Y., Schink, K., Reljic, D., Herrmann, H.J., Dieterich, W., Kiesswetter, E.,... Volkert, D. (2020). Assessing cachexia in older patients: Different definitions – But which one is the most practical for clinical routine? Archives of gerontology and geriatrics, 86. https://doi.org/10.1016/j.archger.2019.103943
- Zundler, S., Tauschek, V., & Neurath, M. (2020). Immune Cell Circuits in Mucosal Wound Healing: Clinical Implications. Visceral Medicine. https://doi.org/10.1159/000506846
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