The research group concentrates on cellular responses to exposure to hazardous substances/xenobiotics. To achieve this objective, the fate of xenobiotics is monitored from the uptake/metabolization to the occurrence of adverse responses. The group uses cell models (2D and 3D models) that are exposed to xenobiotics time- and dose-dependently.
Research projects
Toxicology
Metabolomics
High throughput screening
Modeling – 2D and 3D cell modells
Dose- and time-dependent response
Recent publications
2024
Masutin, V., Kersch, C., Alsaleh, R., & Schmitz-Spanke, S. (2024). Differential effects of benzo[a]pyrene exposure on glutathione and purine metabolism in keratinocytes: Dose-dependent and UV co-exposure effects . Experimental Dermatology , 33 (3). https://doi.org/10.1111/exd.15044
Offer, S., Di Bucchianico, S., Czech, H., Pardo, M., Pantzke, J., Bisig, C.,... Zimmermann, R. (2024). The chemical composition of secondary organic aerosols regulates transcriptomic and metabolomic signaling in an epithelial-endothelial in vitro coculture . Particle and Fibre Toxicology , 21 (1). https://doi.org/10.1186/s12989-024-00600-x
Wohlfahrt, J., Verma, N., Alsaleh, R., Kersch, C., & Schmitz-Spanke, S. (2024). A pilot study exploring time- and dose-dependent DNA damage and chromosomal instability caused by benzo[a]pyrene in two urothelial cell types . Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis , 828 . https://doi.org/10.1016/j.mrfmmm.2024.111855
2022
Masutin, V., Kersch, C., & Schmitz-Spanke, S. (2022). A systematic review: metabolomics-based identification of altered metabolites and pathways in the skin caused by internal and external factors . Experimental Dermatology . https://doi.org/10.1111/exd.14529
Weistenhöfer, W., Golka, K., Bolm-Audorff, U., Bolt, H.M., Bruning, T., Hallier, E.,... Drexler, H. (2022). Work-related bladder cancer -The BK 1301 matrix as an algorithm and decision aid in the context of an assessment of an occupational disease Das beruflich bedingte Harnblasenkarzinom-Die BK 1301-Matrix als Algorithmus und Entscheidungshilfe fur eine Zusammenhangsbegutachtung . Arbeitsmedizin, Sozialmedizin, Umweltmedizin , 2022 (3), 177-189. https://doi.org/10.17147/asu-1-174375
Weistenhöfer, W., Lutz, R., Hiller, J., Schmitz-Spanke, S., & Drexler, H. (2022). Syncarcinogenesis of natural UV radiation and polycyclic aromatic hydrocarbons in the development of squamous cell carcinomas of the skin? Journal der Deutschen Dermatologischen Gesellschaft . https://doi.org/10.1111/ddg.14818
2021
Letzel, S., Schmitz-Spanke, S., Lang, J., & Nowak, D. (Hrg.) (2021). Krebs und Arbeit - Arbeits- und sozialmedizinische Aspekte . Landsberg am Elsch: ecomed-storck GmbH.
Verma, N., Pink, M., & Schmitz-Spanke, S. (2021). A new perspective on calmodulin-regulated calcium and ROS homeostasis upon carbon black nanoparticle exposure . Archives of Toxicology . https://doi.org/10.1007/s00204-021-03032-0
Weistenhöfer, W., Drexler, H., & Schmitz-Spanke, S. (2021). Hemmung der Neurotoxischen Esterase: Bewertung von Studienergebnissen . In Tagungsband 61. Jahrestagung der DGAUM . Jena, DE.
2020
De Rentis, A., Pink, M., Verma, N., & Schmitz-Spanke, S. (2020). Assessment of the different skin sensitization potentials of irritants and allergens as single substances and in combination using the KeratinoSens assay. Contact Dermatitis . https://doi.org/10.1111/cod.13762
Hartwig, A., Arand, M., Epe, B., Guth, S., Jahnke, G., Lampen, A.,... Eisenbrand, G. (2020). Correction to: Mode of action-based risk assessment of genotoxic carcinogens (Archives of Toxicology, (2020), 94, 6, (1787-1877), 10.1007/s00204-020-02733-2) . Archives of Toxicology . https://doi.org/10.1007/s00204-020-02862-8
Hartwig, A., Arand, M., Epe, B., Guth, S., Jahnke, G., Lampen, A.,... Eisenbrand, G. (2020). Mode of action-based risk assessment of genotoxic carcinogens . Archives of Toxicology , 94 (6), 1787-1877. https://doi.org/10.1007/s00204-020-02733-2
Letzel, S., Schmitz-Spanke, S., Lang, J., & Nowak, D. (Hrg.) (2020). Telemedizin - E-Health in der Arbeitsmedizin . Landsberg am Lech: ecomed MEDIZIN.
Pink, M., Verma, N., & Schmitz-Spanke, S. (2020). Benchmark dose analyses of toxic endpoints in lung cells provide sensitivity and toxicity ranking across metal oxide nanoparticles and give insights into the mode of action . Toxicology Letters . https://doi.org/10.1016/j.toxlet.2020.06.012
Weistenhöfer, W., Drexler, H., Hartwig, A., & Schmitz-Spanke, S. (2020). Assessment values in biological material for carcinogenic substances by the example of 1,4-dichlorobenzene . In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (pp. 54-54). Leipzig, DE: NEW YORK: SPRINGER.
Weistenhöfer, W., Hiller, J., Lösch, R., Schmitz-Spanke, S., & Drexler, H. (2020). PAK und UV-Strahlung: Synkanzerogenese? In Proceedings of the 60. Wissenschaftliche Jahrestagung der DGAUM . München, DE.
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The research group concentrates on cellular responses to exposure to hazardous substances/xenobiotics. To achieve this objective, the fate of xenobiotics is monitored from the uptake/metabolization to the occurrence of adverse responses. The group uses cell models (2D and 3D models) that are exposed to xenobiotics time- and dose-dependently.
Research projects
No projects found.
2024
2022
2021
2020
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