Carcinogenesis and inflammation induce processes of tumor and immune cells that interact with the local microenvironment and may have systemic impact resulting in distant metastasis or a systemic response on inflammation, respectively. The primary area of research is to assess these processes by multimodal imaging on the translational and clinical level including MRI, CT, PET, ultrasound, and optical imaging.
Research projects
The aim of our group is to develop novel imaging techniques for the assessment of tumor growth, metastasis, and inflammatory processes for translational purposes in preclinical models and patients
To assess quantitative parameters in local and systemic disease
To implement machine learning algorithms for integration of large amounts of imaging data to detect, diagnose or predict oncologic or inflammatory disease.
Current projects
J107: Deciphering the PU.1 transcriptional network in osteoblasts and its role in osteoproliferative arthritis
(FAU Funds)
Term: 1. January 2024 - 31. August 2026
PU.1 controls the transcriptional network of matrix production in fibrotic fibroblasts. We have now found that PU.1 is also expressed in matrix-producing osteoblasts. In this proposal, we aim to study the PU.1 network in biopsies from patients with osteoproliferative arthritis by imaging mass cytometry, to dissect PU.1-driven transcription in human osteoblastogenic cultures by ATTAC/CHIP/RNA-seq, and to use a novel osteoblast-targeting PU.1 inhibitor in experimental osteoproliferative arthritis.
J106: Tissue imprinting of skin-derived immune cells in psoriatic arthritis
(FAU Funds)
Term: 1. September 2023 - 28. February 2026
To date, it is still obscure why in some patients with psoriasis the autoimmune process is restrained to the skin, whereas in other it extends to the joints. We will adopt models resembling psoriasis and psoriatic arthritis, with the aim of studying the joint involvement secondary to skin inflammation. The comprehension and characterization of the underlying mechanisms involved in the skin-joint axis is pivotal for a better understanding of the link between physical barriers and autoimmunity.
Datenmanagement, Bioinformatik und Imaging-Plattform (Z01)
(Third Party Funds Group – Sub project)
Overall project: TRR 305: Über die Analyse der metastatischen Koloniebildung zu neuen systemischen KrebstherapienTerm: 1. January 2021 - 31. December 2024Funding source: DFG / Sonderforschungsbereich / Transregio (SFB / TRR)
Recent publications
2024
Heger, L., Heidkamp, G.F., Amon, L., Nimmerjahn, F., Bäuerle, T., Maier, A.,... Dudziak, D. (2024). Unbiased high-dimensional flow cytometry identified NK and DC immune cell signature in Luminal A-type and triple negative breast cancer . OncoImmunology , 13 (1). https://doi.org/10.1080/2162402X.2023.2296713
Linnerbauer, M., Lößlein, L., Vandrey, O., Peter, A., Han, Y., Tsaktanis, T.,... Rothhammer, V. (2024). The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology . Nature Immunology . https://doi.org/10.1038/s41590-024-01756-6
Putz, F., Bock, M., Schmitt, D., Bert, C., Blanck, O., Ruge, M.I.,... Wittig, A. (2024). Quality requirements for MRI simulation in cranial stereotactic radiotherapy: a guideline from the German Taskforce “Imaging in Stereotactic Radiotherapy” . Strahlentherapie und Onkologie . https://doi.org/10.1007/s00066-023-02183-6
Rauber, S., Mohammadian, H., Schmidkonz, C., Atzinger, A., Soare, A., Treutlein, C.,... Ramming, A. (2024). CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis . Nature Immunology . https://doi.org/10.1038/s41590-024-01774-4
Sekita, A., Unterweger, H., Berg, S., Ohlmeyer, S., Bäuerle, T., Zheng, K.H.,... Cicha, I. (2024). Accumulation of Iron Oxide-Based Contrast Agents in Rabbit Atherosclerotic Plaques in Relation to Plaque Age and Vulnerability Features . International Journal of Nanomedicine , 19 , 1645-1666. https://doi.org/10.2147/IJN.S430693
Singh, S., Winter, Z., Necker, F., Bäuerle, T., Scholz, M., Bräuer, L., & Paulsen, F. (2024). Corrigendum to "New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering" [Ocul. Surf. 30 (October 2023) 204-212]. Ocular Surface , 33 . https://doi.org/10.1016/j.jtos.2024.04.002
Wegner, F., Heinrichs, H., Stahlmann, K., Molwitz, I., Keller-Yamamura, S., Kloeckner, R.,... Bannas, P. (2024). Motivation and success factors in radiological research in Germany - Results of a survey by the Methodology and Research Working Group of the German Radiological Society Motivation und Erfolgsfaktoren in der radiologischen Forschung in Deutschland Ergebnisse einer Umfrage der AG Methodik und Forschung . Röfo: Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren . https://doi.org/10.1055/a-2350-0023
2023
Blumenberg, V., Busch, G., Baumann, S., Jitschin, R., Iacoboni, G., Gallur, L.,... Subklewe, M. (2023). Early quantification of anti-CD19 CAR T cells by flow cytometry predicts response in R/R DLBCL . Blood Advances , 7 (22), 6844-6849. https://doi.org/10.1182/bloodadvances.2023010364
Bäuerle, T., Dietzel, M., Pinker, K., Bonekamp, D., Zhang, K.S., Schlemmer, H.P.,... Kiessling, F. (2023). Identification of impactful imaging biomarker: Clinical applications for breast and prostate carcinoma . Röfo: Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren . https://doi.org/10.1055/a-2175-4446
Jarraya, M., Roemer, F., Bäuerle, T., Kogan, F., & Guermazi, A. (2023). PET Imaging in Osteoarthritis . PET Clinics , 18 (1), 21-29. https://doi.org/10.1016/j.cpet.2022.09.002
Ranjan, R.A., Muenzner, J.K., Kunze, P., Geppert, C.-I., Rübner, M., Hübner, H.,... Schneider-Stock, R. (2023). The Chorioallantoic Membrane Xenograft Assay as a Reliable Model for Investigating the Biology of Breast Cancer . Cancers , 15 (6). https://doi.org/10.3390/cancers15061704
Seeling, M., Pöhnl, M., Kara, S., Horstmann, N., Riemer, C.D., Wöhner, M.,... Nimmerjahn, F. (2023). Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1 . Immunity , 56 (5), 1046-1063.e7. https://doi.org/10.1016/j.immuni.2023.02.019
Singh, S., Winter, Z., Necker, F., Bäuerle, T., Scholz, M., Bräuer, L., & Paulsen, F. (2023). New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering . Ocular Surface , 30 , 204-212. https://doi.org/10.1016/j.jtos.2023.09.010
Zlatar, L., Timm, T., Lochnit, G., Bilyy, R., Bäuerle, T., Munoz Becerra, M.,... Herrmann, M. (2023). Neutrophil Extracellular Traps Drive Dacryolithiasis . Cells , 12 (14). https://doi.org/10.3390/cells12141857
2022
An, R., Strissel, P., Al-Abboodi, M., Robering, J.W., Reakasame, S., Eckstein, M.,... Kengelbach-Weigand, A. (2022). An Innovative Arteriovenous (AV) Loop Breast Cancer Model Tailored for Cancer Research . Bioengineering , 9 (7). https://doi.org/10.3390/bioengineering9070280
Blumenberg, V., Busch, G., Baumann, S., Jitschin, R., Winkelmann, M., Hellwig, K.,... Subklewe, M. (2022). Early Real Time Quantification of CD19. CAR T Cells By Flow Cytometry As a Predictive Biomarker for Response in Patients with R/R LBCL . In BLOOD (pp. 7522-7523). WASHINGTON: AMER SOC HEMATOLOGY.
Blumenberg, V., Busch, G., Baumann, S., Jitschin, R., Winkelmann, M., Hellwig, K.,... Subklewe, M. (2022). Early Expansion of CD19.CAR-T Cells in vivo identify the Patients at Risk for the Treatment Failure in diffuse large B-Cell Lymphoma . In ONCOLOGY RESEARCH AND TREATMENT (pp. 253-253). BASEL: KARGER.
Bueno-Fortes, S., Muenzner, J.K., Berral-Gonzalez, A., Hampel, C., Lindner, P., Berninger, A.,... Schneider-Stock, R. (2022). A gene signature derived from the loss of cdkn1a (P21) is associated with CMS4 colorectal cancer . Cancers , 14 (1). https://doi.org/10.3390/cancers14010136
Eiblwieser, J., Krumbholz, M., Semper, S., Frey, B., Nagel, L., Bäuerle, T., & Metzler, M. (2022). CtDNA release mechanisms in a therapeutic Ewing Sarcoma mouse model . In KLINISCHE PADIATRIE (pp. 178-178). STUTTGART: GEORG THIEME VERLAG KG.
Gregoric, G., Gaculenko, A., Nagel, L., Popp, V., Maschauer, S., Prante, O.,... Bäuerle, T. (2022). Non-Invasive Characterization of Experimental Bone Metastasis in Obesity Using Multiparametric MRI and PET/CT . Cancers , 14 (10). https://doi.org/10.3390/cancers14102482
Kalinichenko, L., Mühle, C., Jia, T., Anderheiden, F., Datz, M., Eberle, A.-L.,... Müller, C.P. (2022). Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males . Cerebral Cortex . https://doi.org/10.1093/cercor/bhac106
Marino, S., Hannemann, N., Bishop, R.T., Zeng, F., Carrasco, G., Meurisse, S.,... Idris, A.I. (2022). Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis . Biochemical Pharmacology , 195 . https://doi.org/10.1016/j.bcp.2021.114869
Masitho, S., Putz, F., Mengling, V., Reißig, L., Voigt, R., Bäuerle, T.,... Bert, C. (2022). Accuracy of MRI-CT registration in brain stereotactic radiotherapy: Impact of MRI acquisition setup and registration method . Zeitschrift für Medizinische Physik . https://doi.org/10.1016/j.zemedi.2022.04.004
Royzman, D., Andreev, D., Stich, L., Peckert, K., Wild, A., Zinser, E.,... Steinkasserer, A. (2022). The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis . Frontiers in Immunology , 13 . https://doi.org/10.3389/fimmu.2022.936995
Steiner, D., Reinhardt, L., Fischer, L., Popp, V., Körner, C., Geppert, C.-I.,... Arkudas, A. (2022). Impact of Endothelial Progenitor Cells in the Vascularization of Osteogenic Scaffolds . Cells , 11 (6). https://doi.org/10.3390/cells11060926
Treutlein, C., Distler, J., Tascilar, K., Chenguiti Fakhouri, S., Györfi, A.-H., Atzinger, A.,... Bergmann, C. (2022). Assessment of myocardial fibrosis in patients with systemic sclerosis using [Ga-68]Ga-FAPI-04-PET-CT . European Journal of Nuclear Medicine and Molecular Imaging . https://doi.org/10.1007/s00259-022-06081-4
Treutlein, C., Schmidkonz, C., Tascilar, K., Chenguiti Fakhouri, S., Dees, C., Györfi, A.-H.,... Bergmann, C. (2022, June). ASSESSMENT OF SYSTEMIC SCLEROSIS RELATED MYOCARDIAL FIBROSIS BY 68GA-FAPI-04 PET/CT .
Wennmann, M., Goldschmidt, H., Mosebach, J., Hielscher, T., Bäuerle, T., Komljenovic, D.,... Hillengass, J. (2022). Whole-body magnetic resonance imaging plus serological follow-up for early identification of progression in smouldering myeloma patients to prevent development of end-organ damage . British Journal of Haematology . https://doi.org/10.1111/bjh.18232
Zeun, J., Neubeck, S., Lang, V., Flamann, C., Nagel, L., Kunert, T.,... Kremer, A. (2022). HLA-DO: a possible switch between GvHD and GvL effect . In EUROPEAN JOURNAL OF IMMUNOLOGY (pp. 411-411). HOBOKEN: WILEY.
2021
Bergmann, C., Distler, J., Treutlein, C., Tascilar, K., Müller, A., Atzinger, A.,... Schmidkonz, C. (2021). 68GA-FAPI-04 PET/CT STUDY EXTENSION FOR THE ASSESSMENT OF FIBROBLAST ACTIVATION AND RISK EVALUATION IN SYSTEMIC SCLEROSIS-RELATED INTERSTITIAL LUNG DISEASE . In ANNALS OF THE RHEUMATIC DISEASES (pp. 165-166). LONDON: BMJ PUBLISHING GROUP.
Bergmann, C., Distler, J., Treutlein, C., Tascilar, K., Müller, A., Atzinger, A.,... Schmidkonz, C. (2021). 68Ga-FAPI-04 PET-CT for molecular assessment of fibroblast activation and risk evaluation in systemic sclerosis-associated interstitial lung disease: a single-centre, pilot study . The Lancet Rheumatology . https://doi.org/10.1016/S2665-9913(20)30421-5
Bäuerle, T., Gupta, S., Zheng, S., Seyler, L., Leporati, A., Marosfoi, M.,... Bogdanov, A. (2021). Multimodal Bone Metastasis-associated Epidermal Growth Factor Receptor Imaging in an Orthotopic Rat Model. Radiology: Imaging Cancer , 3 (4). https://doi.org/10.1148/rycan.2021200069
Bäuerle, T., & Roemer, F. (2021). Dynamic contrast-enhanced MRI for assessment of subchondral bone marrow vascularization in an experimental osteoarthritis model: a major step towards clinical translation? Osteoarthritis and Cartilage . https://doi.org/10.1016/j.joca.2021.03.001
Ellmann, S., & Bäuerle, T. (2021). Editorial for "Deep Learning Assisted Diagnosis of Musculoskeletal Tumors Based Upon Contrast-Enhanced Magnetic Resonance Imaging" . Journal of Magnetic Resonance Imaging . https://doi.org/10.1002/jmri.28039
Friščić, J., Böttcher, M., Reinwald, C., Bruns, H., Wirth, B., Popp, S.,... Hoffmann, M. (2021). The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts . Immunity . https://doi.org/10.1016/j.immuni.2021.03.003
Gaculenko, A., Gregoric, G., Popp, V., Seyler, L., Ringer, M., Kachler, K.,... Bozec, A. (2021). Systemic PPAR gamma Antagonism Reduces Metastatic Tumor Progression in Adipocyte-Rich Bone in Excess Weight Male Rodents . Journal of Bone and Mineral Research . https://doi.org/10.1002/jbmr.4422
Hartmann, B., Müller, M., Seyler, L., Bäuerle, T., Wilferth, T., Avdievitch, N.,... Nagel, A.M. (2021). Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla . PLoS ONE , 16 (6 June). https://doi.org/10.1371/journal.pone.0252935
Heinen, H., Seyler, L., Popp, V., Hellwig, K., Bozec, A., Uder, M.,... Bäuerle, T. (2021). Morphological, functional, and molecular assessment of breast cancer bone metastases by experimental ultrasound techniques compared with magnetic resonance imaging and histological analysis . Bone , 144 . https://doi.org/10.1016/j.bone.2020.115821
Hellwig, K., Ellmann, S., Eckstein, M., Wiesmüller, M., Rutzner, S., Semrau, S.,... Gostian, A.-O. (2021). Predictive Value of Multiparametric MRI for Response to Single-Cycle Induction Chemo-Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma . Frontiers in Oncology , 11 . https://doi.org/10.3389/fonc.2021.734872
Huhn, K., Linz, P., Pemsel, F., Michalke, B., Seyferth, S., Kopp, C.,... Haase, S. (2021). Skin sodium is increased in male patients with multiple sclerosis and related animal models . Proceedings of the National Academy of Sciences of the United States of America , 118 (28). https://doi.org/10.1073/pnas.2102549118
Kalinichenko, L., Mühle, C., Jia, T., Anderheiden, F., Datz, M., Eberle, A.-L.,... Müller, C.P. (2021). Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects . Molecular Psychiatry . https://doi.org/10.1038/s41380-021-01304-w
Kengelbach-Weigand, A., Thielen, C., Bäuerle, T., Götzl, R., Gerber, T., Körner, C.,... Boos, A. (2021). Personalized medicine for reconstruction of critical-size bone defects – a translational approach with customizable vascularized bone tissue . npj Regenerative Medicine , 6 (1). https://doi.org/10.1038/s41536-021-00158-8
Krumbholz, M., Eiblwieser, J., Ranft, A., Zierk, J., Schmidkonz, C., Stuetz, A.M.,... Metzler, M. (2021). Quantification of translocation-specific ctDNA provides an integrating parameter for early assessment of treatment response and risk stratification in ewing sarcoma . Clinical Cancer Research , 27 (21), 5922-5930. https://doi.org/10.1158/1078-0432.CCR-21-1324
Oprea-Lager, D.E., Cysouw, M.C., Boellaard, R., Deroose, C.M., de Geus-Oei, L.F., Lopci, E.,... Lecouvet, F.E. (2021). Bone Metastases Are Measurable: The Role of Whole-Body MRI and Positron Emission Tomography . Frontiers in Oncology , 11 . https://doi.org/10.3389/fonc.2021.772530
Schmidkonz, C., Distler, J., Treutlein, C., Atzinger, A., Prante, O., Ritt, P.,... Bergmann, C. (2021). Ga-68-FAPI-04 PET/CT for molecular assessment of fibroblast activation and risk evaluation in systemic sclerosis-related interstitial lung disease . European Journal of Nuclear Medicine and Molecular Imaging , S158-S159. https://doi.org/10.1055/s-0041-1726695
Schmidkonz, C., Rauber, S., Atzinger, A., Götz, T.I., Soare, A., Cordes, M.,... Ramming, A. (2021). Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging . European Journal of Nuclear Medicine and Molecular Imaging , S125-S126. https://doi.org/10.1055/s-0041-1726701
Schroeder, A., Seyler, L., Hofmann, E., Gölz, L., Jantsch, J., Proff, P.,... Kirschneck, C. (2021). Administration of a VEGFR-2-specific MRI contrast agent to assess orthodontic tooth movement A pilot study . Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie . https://doi.org/10.1007/s00056-021-00326-x
Wild, M., Kicuntod, J., Seyler, L., Wangen, C., Bertzbach, L.D., Conradie, A.M.,... Marschall, M. (2021). Combinatorial drug treatments reveal promising anticytomegaloviral profiles for clinically relevant pharmaceutical kinase inhibitors (PKIs) . International Journal of Molecular Sciences , 22 (2), 1-20. https://doi.org/10.3390/ijms22020575
2020
Bobinger, T., Bäuerle, T., Seyler, L., von Hörsten, S., Schwab, S., Huttner, H., & Manaenko, A. (2020). A Sphingosine-1-Phosphate Receptor Modulator Attenuated Secondary Brain Injury and Improved Neurological Functions of Mice after ICH . Oxidative Medicine and Cellular Longevity , 2020 . https://doi.org/10.1155/2020/3214350
Bäuerle, T., Saake, M., & Uder, M. (2020). Gadolinium-based contrast agents: What we learned from acute adverse events, nephrogenic systemic fibrosis and brain retention . Röfo: Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren . https://doi.org/10.1055/a-1328-3177
Ellmann, S., Schlicht, M., Dietzel, M., Janka, R.M., Hammon, M., Saake, M.,... Bäuerle, T. (2020). Computer-aided diagnosis in multiparametric mri of the prostate: An open-access online tool for lesion classification with high accuracy . Cancers , 12 (9), 1-15. https://doi.org/10.3390/cancers12092366
Ellmann, S., Seyler, L., Gillmann, C., Popp, V., Treutlein, C., Bozec, A.,... Bäuerle, T. (2020). Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model . Journal of Visualized Experiments , 162 . https://doi.org/10.3791/61235
Ellmann, S., Wenkel, E., Dietzel, M., Bielowski, C., Vesal, S., Maier, A.,... Bäuerle, T. (2020). Implementation of machine learning into clinical breast MRI: Potential for objective and accurate decision-making in suspicious breast masses . PLoS ONE , 1-15 , 1-15. https://doi.org/10.1371/journal.pone.0228446
Friedberger, A., Figueiredo, C., Bäuerle, T., Schett, G., & Engelke, K. (2020). A new method for quantitative assessment of hand muscle volume and fat in magnetic resonance images . BMC Rheumatology , 4 (1). https://doi.org/10.1186/s41927-020-00170-3
Friedberger, A., Figueiredo, C., Grimm, A., Oliveira, I., Bäuerle, T., Rech, J.,... Engelke, K. (2020). Quantification of hand muscle volume and composition in patients with rheumatoid arthritis, psoriatic arthritis and psoriasis . BMC Musculoskeletal Disorders , 21 (1). https://doi.org/10.1186/s12891-020-03194-5
Habermeyer, J., Boyken, J., Harrer, J., Canneva, F., Ratz, V., Moceri, S.,... von Hörsten, S. (2020). Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats . Scientific Reports , 10 (1). https://doi.org/10.1038/s41598-020-79374-z
Häge, S., Sonntag, E., Borst, E.M., Tannig, P., Seyler, L., Bäuerle, T.,... Marschall, M. (2020). Patterns of autologous and nonautologous interactions between core nuclear egress complex (NEC) proteins of α‐, β‐ and γ‐herpesviruses . Viruses , 12 (3). https://doi.org/10.3390/v12030303
Korn, M., Schmitt, H., Angermüller, S., Chambers, D., Seeling, M., Lux, U.,... Nitschke, L. (2020). Siglec-15 on osteoclasts is crucial for bone erosion in serum-Transfer arthritis . Journal of Immunology , 205 (10), 2595-2605. https://doi.org/10.4049/jimmunol.2000472
Kuhbandner, K., Hoffmann, A., Alvarado, M.N., Seyler, L., Bäuerle, T., Winkler, J., & Linker, R. (2020). alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination . Journal of Molecular Neuroscience . https://doi.org/10.1007/s12031-020-01498-8
Lambrecht, V., Hanspach, J., Hoffmann, A., Seyler, L., Mennecke, A., Straub, S.,... Laun, F.B. (2020). Quantitative susceptibility mapping depicts severe myelin deficit and iron deposition in a transgenic model of multiple system atrophy . Experimental Neurology , 329 . https://doi.org/10.1016/j.expneurol.2020.113314
Neri, E., Gabelloni, M., Bäuerle, T., Beets-Tan, R., Caruso, D., D’Anastasi, M.,... Laghi, A. (2020). Involvement of radiologists in oncologic multidisciplinary team meetings: an international survey by the European Society of Oncologic Imaging . European Radiology . https://doi.org/10.1007/s00330-020-07178-w
Proff, P., Schroeder, A., Seyler, L., Wolf, F., Korkmaz, Y., Bäuerle, T.,... Kirschneck, C. (2020). Local Vascularization during Orthodontic Tooth Movement in a Split Mouth Rat Model - A MRI Study . Biomedicines , 8 (12). https://doi.org/10.3390/biomedicines8120632
Putz, F., Mengling, V., Masitho, S., Perrin, R., Roesch, J., Weissmann, T.,... Bert, C. (2020). Does the Planning MRI for cranial Stereotaxy have to be performed in the Irradiation Position? An Examination of Brain Tissue Deformations between MR Imaging in diagnostic and Radiation Positions . In STRAHLENTHERAPIE UND ONKOLOGIE (pp. S200-S201). Weisbaden, DE: HEIDELBERG: SPRINGER HEIDELBERG.
Putz, F., Mengling, V., Perrin, R., Masitho, S., Weissmann, T., Roesch, J.,... Cavallaro, A.J. (2020). Magnetic resonance imaging for brain stereotactic radiotherapy - A review of requirements and pitfalls . Strahlentherapie und Onkologie . https://doi.org/10.1007/s00066-020-01604-0
Roemer, F., Treutlein, C., Guermazi, A., Nagel, A.M., Schett, G., Uder, M., & Bäuerle, T. (2020). ASSESSMENT OF KNEE JOINT SYNOVITIS AT ULTRA-HIGH FIELD (7T) MRI: A MULTI-DIMENSIONAL APPROACH USING CONTRAST-ENHANCED AND NON-ENHANCED SEQUENCES . In OSTEOARTHRITIS AND CARTILAGE (pp. S297-S297). Vienna, AT: OXFORD: ELSEVIER SCI LTD.
Schmidkonz, C., Atzinger, A., Götz, T., Beck, M., Ritt, P., Prante, O.,... Cordes, M. (2020). 99mTc-MIP-1404 SPECT/CT for Patients With Metastatic Prostate Cancer: Interobserver and Intraobserver Variability in Treatment-Related Longitudinal Tracer Uptake Assessments of Prostate-Specific Membrane Antigen-Positive Lesions . Clinical Nuclear Medicine , 45 (2), 105-112. https://doi.org/10.1097/RLU.0000000000002880
Schmidkonz, C., Götz, T.I., Atzinger, A., Ritt, P., Prante, O., Kuwert, T.,... Cordes, M. (2020). 99mTc-MIP-1404 SPECT/CT for Assessment of Whole-Body Tumor Burden and Treatment Response in Patients With Biochemical Recurrence of Prostate Cancer . Clinical Nuclear Medicine . https://doi.org/10.1097/RLU.0000000000003102
Schmidkonz, C., Krumbholz, M., Atzinger, A., Cordes, M., Götz, T., Prante, O.,... Metzler, M. (2020). Correction to: Assessment of treatment responses in children and adolescents with Ewing sarcoma with metabolic tumor parameters derived from 18F-FDG-PET/CT and circulating tumor DNA (European Journal of Nuclear Medicine and Molecular Imaging, (2019), 10.1007/s00259-019-04649-1) . European Journal of Nuclear Medicine and Molecular Imaging . https://doi.org/10.1007/s00259-019-04672-2
Schmidkonz, C., Rauber, S., Atzinger, A., Agarwal, R., Götz, T.I., Soare, A.,... Ramming, A. (2020). Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging . Annals of the Rheumatic Diseases , 79 (11), 1485-1491. https://doi.org/10.1136/annrheumdis-2020-217408
Shi, C., Kim, T., Steiger, S., Mulay, S.R., Klinkhammer, B.M., Bäuerle, T.,... Anders, H.J. (2020). Crystal clots as therapeutic target in cholesterol crystal embolism . Circulation Research , E37-E52. https://doi.org/10.1161/CIRCRESAHA.119.315625
Soare, A., Györfi, A.-H., Matei, A.-E., Dees, C., Rauber, S., Wohlfahrt, T.,... Ramming, A. (2020). Dipeptidylpeptidase 4 as a Marker of Activated Fibroblasts and a Potential Target for the Treatment of Fibrosis in Systemic Sclerosis . Arthritis and Rheumatology , 72 (1), 137-149. https://doi.org/10.1002/art.41058
Treutlein, C., Bäuerle, T., Nagel, A.M., Guermazi, A., Kleyer, A., Simon, D.,... Roemer, F. (2020). Comprehensive assessment of knee joint synovitis at 7 T MRI using contrast-enhanced and non-enhanced sequences . BMC Musculoskeletal Disorders , 21 (1). https://doi.org/10.1186/s12891-020-3122-y
Treutlein, C., Stollberg, A., Scherl, C., Agaimy, A., Ellmann, S., Iro, H.,... Bäuerle, T. (2020). Diagnostic value of 3D dynamic contrast-enhanced magnetic resonance imaging in lymph node metastases of head and neck tumors: a correlation study with histology . Acta Radiologica Open , 9 (8). https://doi.org/10.1177/2058460120951966
Xu, M.M., Seyler, L., Bäuerle, T., Kalinichenko, L., Müller, C.P., Huttner, H.,... Manaenko, A. (2020). Serelaxin activates eNOS, suppresses inflammation, attenuates developmental delay and improves cognitive functions of neonatal rats after germinal matrix hemorrhage . Scientific Reports , 10 (1). https://doi.org/10.1038/s41598-020-65144-4
Related Research Fields
Contact:
Carcinogenesis and inflammation induce processes of tumor and immune cells that interact with the local microenvironment and may have systemic impact resulting in distant metastasis or a systemic response on inflammation, respectively. The primary area of research is to assess these processes by multimodal imaging on the translational and clinical level including MRI, CT, PET, ultrasound, and optical imaging.
Research projects
J107: Deciphering the PU.1 transcriptional network in osteoblasts and its role in osteoproliferative arthritis
(FAU Funds)
J106: Tissue imprinting of skin-derived immune cells in psoriatic arthritis
(FAU Funds)
Datenmanagement, Bioinformatik und Imaging-Plattform (Z01)
(Third Party Funds Group – Sub project)
Term: 1. January 2021 - 31. December 2024
Funding source: DFG / Sonderforschungsbereich / Transregio (SFB / TRR)
2024
2023
2022
2021
2020
Related Research Fields
Contact: