Abscopal effects are rare events of local radiotherapy (RT) inducing systemic anti-tumor immune responses leading to the reduction of tumor masses outside of the irradiation field. We hypothesize that the addition of adjuvants to high hydrostatic pressure generated whole tumor cell vaccines in combination with RT and immune checkpoint inhibition induce abscopal effects in an orthotopic breast cancer model. Further, we hypothesize that cDC1s play a central role in this immune response.
Research projects
Verbundprojekt: Intelligente Tumorverfolgung für die Strahlentherapie (INSIGHT) - Teilvorhaben: Echtzeitverfolgung von Tumorzielvolumina Autosegmentierung und Validierung
(Third Party Funds Group – Sub project)
Term: 1. June 2024 - 31. May 2027
Funding source: BMBF / Verbundprojekt
Entwicklung eines Datenanalyse- und Kommunikations-Clusters zur Unterstützung klinischer Abläufe mit dem Ziel der Steigerung der Behandlungsqualität
(Third Party Funds Single)
Funding source: Bayerisches Staatsministerium für Wirtschaft, Landesentwicklung und Energie (StMWi) (seit 2018)
Clinical traslatio of FLASHKNiFE, a promising device for ultrahigh dose-rate radiation therapy (FLASHKNiFE)
(Third Party Funds Single)
Funding source: Europäische Union (EU)
J102: The role of cDC1s in abscopal effects of a multimodal radioimmunotherapy including whole tumor cell vaccines
(FAU Funds)
2024
2023
2022
2021
2020
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