Research projects
Modelling, characterisation (phenotypic) and experimental therapy in preclinical models for neurodegenerative disorders.
Pharmacovigilance.
Development, testing and validation of equipment for behavioral testing with focus on rodent automated intra-home-cage testing and motor functional analysis
Neurodegeneration, Alzheimers, Parkinsons, Huntington, Spinocerebellar ataxia
Neuropeptides
Dipeptidyl-peptidase IV (CD26)
Glutaminyl-cyclases
Recent publications
2024
Breivik, T.J., Gjermo, P., Gundersen, Y., Opstad, P.K., Murison, R., Hugoson, A.,... Fristad, I. (2024). Microbiota-immune-brain interactions: A new vision in the understanding of periodontal health and disease . Periodontology 2000 . https://doi.org/10.1111/prd.12610
Moceri, S., Bäuerle, N., Habermeyer, J., Ratz-Wirsching, V., Harrer, J., Distler, J.,... von Hörsten, S. (2024). Young human alpha synuclein transgenic (BAC-SNCA) mice display sex- and gene-dose-dependent phenotypic disturbances . Behavioural Brain Research , 460 . https://doi.org/10.1016/j.bbr.2023.114781
Ratz-Wirsching, V., Habermeyer, J., Moceri, S., Harrer, J., Schmitz, C., & von Hörsten, S. (2024). Gene-dosage- and sex-dependent differences in the prodromal-Like phase of the F344tgHD rat model for Huntington disease . Frontiers in Neuroscience , 18 . https://doi.org/10.3389/fnins.2024.1354977
Sankina, P., Lal, R., Khare, P., von Hörsten, S., Fester, L., Aggarwal, V.,... Bishnoi, M. (2024). Topical menthol, a pharmacological cold mimic, induces cold sensitivity, adaptive thermogenesis and brown adipose tissue activation in mice . Diabetes Obesity & Metabolism , 26 (10), 4329-4345. https://doi.org/10.1111/dom.15781
2023
Chestnykh, D., Graßl, F., Pfeifer, C., Dülk, J., Ebner, C., Walters, M.,... Müller, C.P. (2023). Behavioural effects of APH199, a selective dopamine D4 receptor agonist, in animal models . Psychopharmacology . https://doi.org/10.1007/s00213-023-06347-1
Schmitt, V., Masanetz, R.K., Weidenfeller, M., Ebbinghaus, L.S., Süß, P., Rosshart, S.P.,... Xiang, W. (2023). Gut-to-brain spreading of pathology in synucleinopathies: A focus on molecular signalling mediators . Behavioural Brain Research , 452 . https://doi.org/10.1016/j.bbr.2023.114574
Sommer, J., Ehnis, H., Seitz, T., Schneider, J., Wild, A., Moceri, S.,... Hellerbrand, C. (2023). Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity . International Journal of Molecular Sciences , 24 (19). https://doi.org/10.3390/ijms241914943
Timotius, I.K., Roelofs, R.F., Richmond-Hacham, B., Noldus, L.P., von Hörsten, S., & Bikovski, L. (2023). CatWalk XT gait parameters: a review of reported parameters in pre-clinical studies of multiple central nervous system and peripheral nervous system disease models . Frontiers in Behavioral Neuroscience , 17 . https://doi.org/10.3389/fnbeh.2023.1147784
Vaghela, R., Arkudas, A., Gage, D., Körner, C., von Hörsten, S., Salehi, S.,... Hessenauer, M. (2023). A Novel Window into Angiogenesis — Intravital Microscopy in the AV-Loop-Model . Cells , 12 (2). https://doi.org/10.3390/cells12020261
2022
Bluhm, A., Schrempel, S., Moceri, S., Stieler, J., Feja, M., Schilling, S.,... Roßner, S. (2022). Alpha synuclein processing by MMP-3 – implications for synucleinopathies . Behavioural Brain Research , 434 . https://doi.org/10.1016/j.bbr.2022.114020
Bluhm, A., Schrempel, S., Schilling, S., von Hörsten, S., Schulze, A., Rossner, S., & Hartlage-Ruebsamen, M. (2022). Immunohistochemical Demonstration of the pGlu79 alpha-Synuclein Fragment in Alzheimer's Disease and Its Tg2576 Mouse Model . Biomolecules , 12 (7). https://doi.org/10.3390/biom12071006
2021
Bluhm, A., Schrempel, S., von Hörsten, S., Schulze, A., & Roßner, S. (2021). Proteolytic α‐synuclein cleavage in health and disease . International Journal of Molecular Sciences , 22 (11). https://doi.org/10.3390/ijms22115450
Clemen, C.S., Schmidt, A., Winter, L., Canneva, F., Wittig, I., Becker, L.,... Schröder, R. (2021). N471D WASH complex subunit strumpellin knock-in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue . Neuropathology and Applied Neurobiology . https://doi.org/10.1111/nan.12750
Golub, Y., Stonawski, V., Plank, A.-C., Eichler, A., Kratz, O., Waltes, R.,... Freitag, C.M. (2021). Anxiety Is Associated With DPPIV Alterations in Children With Selective Mutism and Social Anxiety Disorder: A Pilot Study . Frontiers in Psychiatry , 12 . https://doi.org/10.3389/fpsyt.2021.644553
Hartlage-Rübsamen, M., Bluhm, A., Moceri, S., Machner, L., Köppen, J., Schenk, M.,... Roßner, S. (2021). A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies . Acta Neuropathologica . https://doi.org/10.1007/s00401-021-02349-5
Mészáros, L., Riemenschneider, M.J., Gaßner, H., Marxreiter, F., von Hörsten, S., Hoffmann, A., & Winkler, J. (2021). Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy . Acta Neuropathologica Communications , 9 (1). https://doi.org/10.1186/s40478-021-01166-x
Plank, A.-C., Frey, S., Basedow, L.A., Solati, J., Canneva, F., von Hörsten, S.,... Golub, Y. (2021). Prenatally traumatized mice reveal hippocampal methylation and expression changes of the stress-related genes Crhr1 and Fkbp5 . Translational Psychiatry , 11 (1). https://doi.org/10.1038/s41398-021-01293-y
Schmid, F., Mayer, C., Büttner-Herold, M., von Hörsten, S., Amann, K.U., & Daniel, C. (2021). CD161a-positive natural killer (NK) cells and α-smooth muscle actin-positive myofibroblasts were upregulated by extrarenal DPP4 in a rat model of acute renal rejection . Diabetes Research and Clinical Practice , 173 . https://doi.org/10.1016/j.diabres.2021.108691
Schmiedl, A., Wagener, I., Jungen, M., von Hörsten, S., & Stephan, M. (2021). Lung development and immune status under chronic LPS exposure in rat pups with and without CD26/DPP4 deficiency . Cell and Tissue Research . https://doi.org/10.1007/s00441-021-03522-8
Schulze-Krebs, A., Canneva, F., Stemick, J., Plank, A.-C., Harrer, J., Bates, G.P.,... von Hörsten, S. (2021). Transglutaminase 6 is colocalized and interacts with mutant huntingtin in huntington disease rodent animal models . International Journal of Molecular Sciences , 22 (16). https://doi.org/10.3390/ijms22168914
2020
Bobinger, T., Bäuerle, T., Seyler, L., von Hörsten, S., Schwab, S., Huttner, H., & Manaenko, A. (2020). A Sphingosine-1-Phosphate Receptor Modulator Attenuated Secondary Brain Injury and Improved Neurological Functions of Mice after ICH . Oxidative Medicine and Cellular Longevity , 2020 . https://doi.org/10.1155/2020/3214350
Cheong, R.Y., Tonetto, S., von Hörsten, S., & Petersén, Å. (2020). Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease . Psychoneuroendocrinology , 119 . https://doi.org/10.1016/j.psyneuen.2020.104773
Dietrich, P., Wormser, L., Fritz, V., Seitz, T., de Maria, M., Schambony, A.,... Hellerbrand, C. (2020). Molecular cross-talk between Y5-receptor and neuropeptide Y drives liver cancer . Journal of Clinical Investigation , 130 (5), 2509-2526. https://doi.org/10.1172/JCI131919
Habermeyer, J., Boyken, J., Harrer, J., Canneva, F., Ratz, V., Moceri, S.,... von Hörsten, S. (2020). Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats . Scientific Reports , 10 (1). https://doi.org/10.1038/s41598-020-79374-z
Haskamp, S., Bruns, H., Hahn, M., Hoffmann, M., Gregor, A., Löhr, S.,... Schauer, C. (2020). Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases . American Journal of Human Genetics , 107 (3), 527-538. https://doi.org/10.1016/j.ajhg.2020.07.001
König, C., Plank, A.-C., Kapp, A., Timotius, I., von Hörsten, S., & Zimmermann, K. (2020). Thirty Mouse Strain Survey of Voluntary Physical Activity and Energy Expenditure: Influence of Strain, Sex and Day–Night Variation . Frontiers in Neuroscience , 14 . https://doi.org/10.3389/fnins.2020.00531
Köppen, J., Schulze, A., Machner, L., Wermann, M., Eichentopf, R., Guthardt, M.,... Schilling, S. (2020). Amyloid-beta peptides trigger aggregation of alpha-synuclein in vitro . Molecules , 25 (3). https://doi.org/10.3390/molecules25030580
Soare, A., Györfi, A.-H., Matei, A.-E., Dees, C., Rauber, S., Wohlfahrt, T.,... Ramming, A. (2020). Dipeptidylpeptidase 4 as a Marker of Activated Fibroblasts and a Potential Target for the Treatment of Fibrosis in Systemic Sclerosis . Arthritis and Rheumatology , 72 (1), 137-149. https://doi.org/10.1002/art.41058
Stemick, J., Gauer, C., Wihan, J., Moceri, S., Xiang, W., von Hörsten, S.,... Winkler, J. (2020). Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson's disease . Brain Research , 1748 . https://doi.org/10.1016/j.brainres.2020.147119
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