Prof. Dr. Christoph Alexiou

2024

• Adler, M.-Y., Issoual, I., Rückert, M., Deloch, L., Meier, C., Tschernig, T.,... Paulsen, F. (2024). Effect of micro- and nanoplastic particles on human macrophages. Journal of Hazardous Materials, 471. https://doi.org/10.1016/j.jhazmat.2024.134253
• Janko, C., Civelek, M., Cicha, I., Spielvogel, H., Unterweger, H., & Alexiou, C. (2024). Nanoparticles for the treatment of inflammatory conditions. Nanomedicine, 19(2), 103-107. https://doi.org/10.2217/nnm-2023-0324
• Kurtuldu, F., Mutlu, N., Friedrich, R.P., Beltrán, A.M., Liverani, L., Detsch, R.,... Boccaccini, A.R. (2024). Gallium-containing mesoporous nanoparticles influence in-vitro osteogenic and osteoclastic activity. Biomaterials Advances, 162. https://doi.org/10.1016/j.bioadv.2024.213922
• Liang, C., Spörl, S., Xiao, Y., Habenicht, K.M., Haeusl, S.S., Sandner, I.,... Berberich-Siebelt, F. (2024). Oligoclonal CD4+CXCR5+ T cells with a cytotoxic phenotype appear in tonsils and blood. Communications Biology, 7(1). https://doi.org/10.1038/s42003-024-06563-1
• Mickoleit, F., Pfister, F., Friedrich, B., Markert, S., Kerpes, A., Janko, C.,... Tietze, R. (2024). Assessing Cytotoxicity, Endotoxicity, and Blood Compatibility of Nanoscale Iron Oxide Magnetosomes for Biomedical Applications. ACS Applied Nano Materials, 7(1), 1278-1288. https://doi.org/10.1021/acsanm.3c05248
• Pourshahrestani, S., Zeimaran, E., Janko, C., Alexiou, C., Kerpes, A., Würz, A.,... Boccaccini, A.R. (2024). The effect of mesoporous bioactive glass nanoparticles incorporating various metallic ions (Cu, Zn, Mn, Te) on wound healing. Materials Advances, 5(16), 6630-6647. https://doi.org/10.1039/d4ma00392f
• Promny, D., Gill, D., Lyer, S., Alexiou, C., Buder, T., Neuhuber, W.,... Arkudas, A. (2024). Mapping wrist motion: 3D CT analysis after scapholunate ligament transection. Journal of Anatomy. https://doi.org/10.1111/joa.14119
• Sekita, A., Unterweger, H., Berg, S., Ohlmeyer, S., Bäuerle, T., Zheng, K.H.,... Cicha, I. (2024). Accumulation of Iron Oxide-Based Contrast Agents in Rabbit Atherosclerotic Plaques in Relation to Plaque Age and Vulnerability Features. International Journal of Nanomedicine, 19, 1645-1666. https://doi.org/10.2147/IJN.S430693
• Zheng, K., Bider, F., Monavari, M., Xu, Z., Janko, C., Alexiou, C.,... Boccaccini, A.R. (2024). Sol-gel derived B2O3-CaO borate bioactive glasses with hemostatic, antibacterial and pro-angiogenic activities. Regenerative Biomaterials, 11. https://doi.org/10.1093/rb/rbad105

2023

• Dinter, J., Friedrich, R.P., Yang, H., Pilarsky, C., Mangge, H., Pöttler, M.,... Lyer, S. (2023). Mitoxantrone and Mitoxantrone-Loaded Iron Oxide Nanoparticles Induce Cell Death in Human Pancreatic Ductal Adenocarcinoma Cell Spheroids. Materials, 16(7). https://doi.org/10.3390/ma16072906
• Friedrich, B., Tietze, R., Dümig, M., Sover, A., Boca, M.A., Schreiber, E.,... Lyer, S. (2023). Magnetic Removal of Candida albicans Using Salivary Peptide-Functionalized SPIONs. International Journal of Nanomedicine, 18, 3231-3246. https://doi.org/10.2147/IJN.S409559
• Friedrich, B., Tietze, R., Rückert, M.A., Kampf, T., Hennig, T., Dölken, L.,... Lyer, S. (2023). Fast detection of SARS-CoV2 Antibodies by the use of critical off-set magnetic particle spectroscopy (COMPASS). International Journal of Magnetic Particle Imaging, 9. https://doi.org/10.18416/IJMPI.2023.2303063
• Friedrich, B., Vogel, P., Rückert, M.A., Lyer, S., Günther, J., Wernery, U.,... Tietze, R. (2023). Detection of viral antibodies in camel sera using magnetic particle spectroscopy. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-023-12513-4
• Genc, H., Cianciosi, A., Lohse, R., Stahlhut, P., Groll, J., Alexiou, C.,... Juengst, T. (2023). Adjusting Degree of Modification and Composition of gelAGE-Based Hydrogels Improves Long-Term Survival and Function of Primary Human Fibroblasts and Endothelial Cells in 3D Cultures. Biomacromolecules. https://doi.org/10.1021/acs.biomac.2c01536
• Genc, H., Friedrich, B., Alexiou, C., Pietryga, K., Cicha, I., & Douglas, T.E. (2023). Endothelialization of Whey Protein Isolate-Based Scaffolds for Tissue Regeneration. Molecules, 28(20). https://doi.org/10.3390/molecules28207052
• Günther, J., Kampf, T., Rückert, M.A., Friedrich, B., Tietze, R., Lyer, S.,... Vogel, P. (2023). Insight COMPASS – the physics behind. International Journal of Magnetic Particle Imaging, 9(1). https://doi.org/10.18416/IJMPI.2023.2303089
• Heger, L., Hatscher, L., Liang, C., Lehmann, C., Amon, L., Lühr, J.J.,... Dudziak, D. (2023). XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors. Proceedings of the National Academy of Sciences of the United States of America, 120(33), e2300343120. https://doi.org/10.1073/pnas.2300343120
• Klemt, I., Varzatskii, O., Selin, R., Vakarov, S., Kovalska, V.B., Bila, G.,... Mokhir, A. (2023). 3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo. Journal of the American Chemical Society, 22252–22264. https://doi.org/10.1021/jacs.3c08827
• Lotter, S., Brand, L., Jamali, V., Schäfer, M., Loos, H., Unterweger, H.,... Schober, R. (2023). Experimental Research in Synthetic Molecular Communications - Part I. IEEE Nanotechnology Magazine, 1-12. https://doi.org/10.1109/MNANO.2023.3262100
• Lotter, S., Brand, L., Jamali, V., Schäfer, M., Loos, H.M., Unterweger, H.,... Schober, R. (2023). Experimental Research in Synthetic Molecular Communications - Part II. IEEE Nanotechnology Magazine, 1-12. https://doi.org/10.1109/MNANO.2023.3262377
• Lyer, S., Blersch, P.-R., Huber, C., Tietze, R., & Alexiou, C. (2023). Digitalization and (Nano)robotics in nanomedicine. In Ralf Huss (Eds.), Digital Medicine: Bringing Digital Solutions to Medical Practice. New York: Jenny Stanford Publishing.
• Pfister, F., Alexiou, C., & Janko, C. (2023). Cell Viability and Immunogenic Function of T Cells Loaded with Nanoparticles for Spatial Guidance in Magnetic Fields. In (pp. 331-346). Humana Press Inc..
• Pfister, F., Dörrie, J., Schaft, N., Buchele, V., Unterweger, H., Carnell, L.R.,... Janko, C. (2023). Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1223695
• Reinelt, M., Ahlfs, J., Stein, R., Alexiou, C., Bänsch, E., Friedrich, R.P.,... Neuß, N. (2023). Simulation and experimental validation of magnetic nanoparticle accumulation in a bloodstream mimicking flow system. Journal of Magnetism and Magnetic Materials, 582. https://doi.org/10.1016/j.jmmm.2023.170984
• Sebastian, S., Hoffmann, M.K., Howard, D., Young, C., Washington, J., Unterweger, H.,... Kempson, I. (2023). Kinetic Effects of Transferrin-Conjugated Gold Nanoparticles on the Antioxidant Glutathione-Thioredoxin Pathway. Antioxidants, 12(8). https://doi.org/10.3390/antiox12081617
• Tietze, R., Unterweger, H., Janko, C., Civelek, M., Cicha, I., Spielvogel, H., & Alexiou, C. (2023). Orally administered nanoparticles for gastrointestinal applications. Nanomedicine. https://doi.org/10.2217/nnm-2022-0324
• Unterweger, H., Janko, C., Civelek, M., Cicha, I., Spielvogel, H., Tietze, R.,... Alexiou, C. (2023). Nanomaterial-based ophthalmic therapies. Nanomedicine, 18(10), 783-788. https://doi.org/10.2217/nnm-2023-0109
• Unterweger, H., Janko, C., Folk, T., Cicha, I., Kovacs, N., Gyebnar, G.,... Lyer, S. (2023). Comparative in vitro and in vivo Evaluation of Different Iron Oxide-Based Contrast Agents to Promote Clinical Translation in Compliance with Patient Safety. International Journal of Nanomedicine, 18, 2071-2086. https://doi.org/10.2147/IJN.S402320
• Wirthl, B., Janko, C., Lyer, S., Schrefler, B.A., Alexiou, C., & Wall, W.A. (2023). An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow. Biomedical Microdevices, 26(1), 1-. https://doi.org/10.1007/s10544-023-00685-9
• Zschiesche, L., Janko, C., Friedrich, B., Frey, B., Band, J., Lyer, S.,... Unterweger, H. (2023). Biocompatibility of Dextran-Coated 30 nm and 80 nm Sized SPIONs towards Monocytes, Dendritic Cells and Lymphocytes. Nanomaterials, 13(1). https://doi.org/10.3390/nano13010014

2022

• Alexiou, C. (2022). Emerging applications of magnetic nanoparticles in medicine – A personal perspective. Biochemical and Biophysical Research Communications, 633, 52-54. https://doi.org/10.1016/j.bbrc.2022.09.020
• Behr, J., Carnell, L.R.R., Stein, R., Pfister, F., Friedrich, B., Huber, C.,... Janko, C. (2022). In Vitro Setup for Determination of Nanoparticle-Mediated Magnetic Cell and Drug Accumulation in Tumor Spheroids under Flow Conditions. Cancers, 14(23). https://doi.org/10.3390/cancers14235978
• Cicha, I., Tietze, R., Unterweger, H., Lyer, S., Janko, C., Civelek, M., & Alexiou, C. (2022). Stimuli-responsive nanosystems for enhanced drug delivery and diagnosis. Nanomedicine. https://doi.org/10.2217/nnm-2022-0193
• Fauck, V., Schinz, K., Alexiou, C., Mantsopoulos, K., Iro, H., & Müller, S.K. (2022). Abscesstonsillectomy: Uni- or bilateral? Laryngo-Rhino-Otologie. https://doi.org/10.1055/a-1841-6419
• Friedrich, B., Eichermüller, J., Bogdan, C., Cunningham, S., Hackstein, H., Strauss, R.,... Tietze, R. (2022). Biomimetic Magnetic Particles for the Removal of Gram-Positive Bacteria and Lipoteichoic Acid. Pharmaceutics, 14(11). https://doi.org/10.3390/pharmaceutics14112356
• Friedrich, B., Lyer, S., Janko, C., Unterweger, H., Brox, R., Cunningham, S.,... Tietze, R. (2022). Scavenging of bacteria or bacterial products by magnetic particles functionalized with a broad-spectrum pathogen recognition receptor motif offers diagnostic and therapeutic applications. Acta Biomaterialia, 141, 418-428. https://doi.org/10.1016/j.actbio.2022.01.001
• Friedrich, R.P., Cicha, I., Tietze, R., Unterweger, H., Lyer, S., Janko, C., & Alexiou, C. (2022). Intranasal delivery of nanoparticles. Nanomedicine. https://doi.org/10.2217/nnm-2021-0418
• Friedrich, R.P., Kappes, M., Cicha, I., Tietze, R., Braun, C., Schneider-Stock, R.,... Janko, C. (2022). Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles. International Journal of Nanomedicine, Volume 17, 2139-2163. https://doi.org/10.2147/IJN.S355007
• Gill, D., Lyer, S., Alexiou, C., Fried, F., Buder, T., Neuhuber, W.,... Arkudas, A. (2022). Anatomical study of all carpal and adjoining bones of the wrist using 3D CT reconstruction –Finding the ultimate biomechanical theory. Annals of Anatomy-Anatomischer Anzeiger, 242. https://doi.org/10.1016/j.aanat.2022.151909
• Holler, A., Cicha, I., Eckstein, M., Haderlein, M., Poettler, M., Rappl, A.,... Alexiou, C. (2022). Extramedullary plasmacytoma: Tumor occurrence and therapeutic concepts-A follow-up. Cancer Medicine. https://doi.org/10.1002/cam4.4816
• Kappes, M., Friedrich, B., Pfister, F., Huber, C., Friedrich, R.P., Stein, R.,... Janko, C. (2022). Superparamagnetic Iron Oxide Nanoparticles for Targeted Cell Seeding: Magnetic Patterning and Magnetic 3D Cell Culture. Advanced Functional Materials. https://doi.org/10.1002/adfm.202203672
• Ryma, M., Genc, H., Nadernezhad, A., Paulus, I., Schneidereit, D., Friedrich, O.,... Groll, J. (2022). A Print-and-Fuse Strategy for Sacrificial Filaments Enables Biomimetically Structured Perfusable Microvascular Networks with Functional Endothelium Inside 3D Hydrogels. Advanced Materials. https://doi.org/10.1002/adma.202200653
• Stein, R., Pfister, F., Friedrich, B., Blersch, P.-R., Unterweger, H., Arkhypov, A.,... Tietze, R. (2022). Plasmid-DNA Delivery by Covalently Functionalized PEI-SPIONs as a Potential ‘Magnetofection’ Agent. Molecules, 27(21). https://doi.org/10.3390/molecules27217416
• Vogel, P., Rückert, M.A., Friedrich, B., Tietze, R., Lyer, S., Kampf, T.,... Behr, V.C. (2022). Critical Offset Magnetic PArticle SpectroScopy for rapid and highly sensitive medical point-of-care diagnostics. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-34941-y
• Xu, H., Reshetnikov, V., Wondrak, M., Eckhardt, L., Kunz-Schughart, L.A., Janko, C.,... Mokhir, A. (2022). Intracellular amplifiers of reactive oxygen species affecting mitochondria as radiosensitizers. Cancers, 14(1). https://doi.org/10.3390/cancers14010208

2021

• Balk, M., Haus, T., Band, J., Unterweger, H., Schreiber, E., Friedrich, R.P.,... Gostian, A.O. (2021). Cellular spion uptake and toxicity in various head and neck cancer cell lines. Nanomaterials, 11(3), 1-19. https://doi.org/10.3390/nano11030726
• Blumler, P., Friedrich, R.P., Pereira, J., Baun, O., Alexiou, C., & Mailander, V. (2021). Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields. Nanotechnology, Science and Applications, 14, 91-100. https://doi.org/10.2147/NSA.S298003
• Boosz, P., Pfister, F., Stein, R., Friedrich, B., Fester, L., Band, J.,... Janko, C. (2021). Citrate-coated superparamagnetic iron oxide nanoparticles enable a stable non-spilling loading of t cells and their magnetic accumulation. Cancers, 13(16). https://doi.org/10.3390/cancers13164143
• Cicha, I., & Alexiou, C. (2021). Cardiovascular applications of magnetic particles. Journal of Magnetism and Magnetic Materials, 518. https://doi.org/10.1016/j.jmmm.2020.167428
• Friedrich, B., Auger, J.-P., Dutz, S., Cicha, I., Schreiber, E., Band, J.,... Tietze, R. (2021). Hydroxyapatite-Coated SPIONs and Their Influence on Cytokine Release. International Journal of Molecular Sciences, 22(8). https://doi.org/10.3390/ijms22084143
• Friedrich, R.P., Cicha, I., & Alexiou, C. (2021). Iron oxide nanoparticles in regenerative medicine and tissue engineering. Nanomaterials, 11(9). https://doi.org/10.3390/nano11092337
• Friedrich, R.P., Janko, C., Unterweger, H., Lyer, S., & Alexiou, C. (2021). SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications. Physical Sciences Review. https://doi.org/10.1515/psr-2019-0093
• Genc, H., Hazur, J., Karakaya, E., Dietel, B., Bider, F., Groll, J.,... Cicha, I. (2021). Differential responses to bioink‐induced oxidative stress in endothelial cells and fibroblasts. International Journal of Molecular Sciences, 22(5), 1-21. https://doi.org/10.3390/ijms22052358
• Gresing, L.J., Radon, P., Friedrich, R.P., Zahn, D., Raasch, M., Mosig, A.S.,... Clement, J.H. (2021). Negatively charged magnetic nanoparticles pass the blood-placenta barrier under continuous flow conditions in a time-dependent manner. Journal of Magnetism and Magnetic Materials, 521. https://doi.org/10.1016/j.jmmm.2020.167535
• Janko, C., Friedrich, R.P., Cicha, I., Unterweger, H., Lyer, S., & Alexiou, C. (2021). Modulation of immune responses by nanoparticles. Nanomedicine. https://doi.org/10.2217/nnm-2021-0198
• Kopeć, K., Wojasiński, M., Eichler, M., Genc, H., Friedrich, R.P., Stein, R.,... Cicha, I. (2021). Polydopamine and gelatin coating for rapid endothelialization of vascular scaffolds. Materials Science and Engineering C. https://doi.org/10.1016/j.msec.2021.112544
• Lyer, S., Janko, C., Friedrich, R.P., Cicha, I., Tietze, R., Unterweger, H., & Alexiou, C. (2021). Nanomedicine for vaccination and diagnosis of diseases. Nanomedicine, 16(3), 165-169. https://doi.org/10.2217/nnm-2020-0483
• Sarcletti, M., Park, H., Wirth, J., Englisch, S., Eigen, A., Drobek, D.,... Halik, M. (2021). The remediation of nano-/microplastics from water. Materials Today. https://doi.org/10.1016/j.mattod.2021.02.020
• Wicke, W., Unterweger, H., Kirchner, J., Brand, L., Ahmadzadeh, A., Ahmed, D.,... Schober, R. (2021). Experimental System for Molecular Communication in Pipe Flow With Magnetic Nanoparticles. IEEE Transactions on Molecular, Biological and Multi-Scale Communications. https://doi.org/10.1109/TMBMC.2021.3099399
• Xu, H., Schikora, M., Sisa, M., Daum, S., Klemt, I., Janko, C.,... Mokhir, A. (2021). An Endoplasmic Reticulum Specific Pro-amplifier of Reactive Oxygen Species in Cancer Cells. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202100054

2020

• Bartunik, M., Unterweger, H., Alexiou, C., Schober, R., Lübke, M., Fischer, G., & Kirchner, J. (2020). Comparative Evaluation of a New Sensor for Superparamagnetic Iron Oxide Nanoparticles in a Molecular Communication Setting. In Springer International Publishing (Eds.), Proceedings of the EAI BICT 2020 - 12th EAI International Conference on Bio-inspired Information and Communications Technologies (pp. 303-316). Online.
• Corek, E., Rodgers, G., Siegrist, S., Einfalt, T., Detampel, P., Schleputz, C.M.,... Huwyler, J. (2020). Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution. Small, e2000746-. https://doi.org/10.1002/smll.202000746
• Fadeel, B., & Alexiou, C. (2020). Brave new world revisited: Focus on nanomedicine. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/j.bbrc.2020.08.046
• Friedrich, R.P., Schreiber, E., Tietze, R., Yang, H., Pilarsky, C., & Alexiou, C. (2020). Intracellular Quantification and Localization of Label-Free Iron Oxide Nanoparticles by Holotomographic Microscopy. Nanotechnology, Science and Applications, 13, 119-130. https://doi.org/10.2147/NSA.S282204
• Gräfe, C., Müller, E.K., Gresing, L., Weidner, A., Radon, P., Friedrich, R.P.,... Clement, J.H. (2020). Magnetic hybrid materials interact with biological matrices. Physical Sciences Review. https://doi.org/10.1515/psr-2019-0114
• Lenz, T., Nicol, P., Castellanos, M.I., Engel, L.C., Lahmann, A.L., Alexiou, C., & Joner, M. (2020). Small dimension–Big impact! Nanoparticle-enhanced non-invasive and intravascular molecular imaging of atherosclerosis in vivo. Molecules, 25(5). https://doi.org/10.3390/molecules25051029
• Mühlberger, M., Unterweger, H., Band, J., Lehmann, C., Heger, L., Dudziak, D.,... Janko, C. (2020). Loading of Primary Human T Lymphocytes with Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles Does Not Impair Their Activation after Polyclonal Stimulation. Cells, 9(2). https://doi.org/10.3390/cells9020342
• Nguyen, K., Nuß, B., Mühlberger, M., Unterweger, H., Friedrich, R.P., Alexiou, C., & Janko, C. (2020). Superparamagnetic iron oxide nanoparticles carrying chemotherapeutics improve drug efficacy in monolayer and spheroid cell culture by enabling active accumulation. Nanomaterials, 10(8), 1-21. https://doi.org/10.3390/nano10081577
• Podolska, M., Barras, A., Alexiou, C., Frey, B., Gaipl, U., Boukherroub, R.,... Munoz, L.E. (2020). Graphene Oxide Nanosheets for Localized Hyperthermia-Physicochemical Characterization, Biocompatibility, and Induction of Tumor Cell Death. Cells, 9(3). https://doi.org/10.3390/cells9030776
• Ratschker, T., Egenberger, L., Alev, M., Zschiesche, L., Band, J., Schreiber, E.,... Janko, C. (2020). Mitoxantrone-loaded nanoparticles for magnetically controlled tumor therapy–induction of tumor cell death, release of danger signals and activation of immune cells. Pharmaceutics, 12(10), 1-19. https://doi.org/10.3390/pharmaceutics12100923
• Reshetnikov, V., Özkan, H., Daum, S., Janko, C., Alexiou, C., Sauer, C.,... Mokhir, A. (2020). N-Alkylaminoferrocene-Based Prodrugs Targeting Mitochondria of Cancer Cells. Molecules, 25(11). https://doi.org/10.3390/molecules25112545
• Schapher, M., Koch, M., Weidner, D., Scholz, M., Wirtz, S., Mahajan, A.,... Schauer, C. (2020). Neutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones. Cells, 9(9). https://doi.org/10.3390/cells9092139
• Singh, R., Eitler, D., Morelle, R., Friedrich, R.P., Dietel, B., Alexiou, C.,... Cicha, I. (2020). Optimization of cell seeding on electrospun PCL-silk fibroin scaffolds. European Polymer Journal, 134. https://doi.org/10.1016/j.eurpolymj.2020.109838
• Stein, R., Friedrich, B., Mühlberger, M., Cebulla, N., Schreiber, E., Tietze, R.,... Unterweger, H. (2020). Synthesis and characterization of citrate-stabilized gold-coated superparamagnetic iron oxide nanoparticles for biomedical applications. Molecules, 25(19). https://doi.org/10.3390/molecules25194425
• Zeh, G., Haines, P., Miehlich, M., Kienz, T., Neidlinger, A., Friedrich, R.P.,... Mokhir, A. (2020). Anticancer Effect of an Electronically Coupled Oligoferrocene. Organometallics. https://doi.org/10.1021/acs.organomet.0c00306